| Drug Name: | St JohnÆs wort (84082-80-4) |
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This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Aminolevulinic acid (106-60-5) | Phototoxicity | Synergistic | Not known | Synergistic toxicity of delta-aminolaevulinic acid-induced protoporphyrin IX used for photodiagnosis and hypericum extract, a herbal antidepressant |
| Carbamazepine (298-46-4) | Increased The Clearance Of Carbamazepine | Antagonistic | St John’s wort is not sufficiently potent an inducer to further induce carbamazepine metabolism when autoinduction has occurred, 1 and therefore a small interaction is seen with single doses but no interaction is seen with multiple doses | Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers |
| Etoposide (33419-42-0) | Depression | Antagonistic | stimulate the hepatic metabolism of etoposide by the cytochrome P450 isoenzyme CYP3A4. | Catalytic inhibition of human DNA topoisomerase II? by hypericin, a naphthodianthrone from St John’s wort (Hypericum perforatum) |
| Irinotecan (97682-44-5) | Reduced Efficacy | Antagonistic | St John’s wort induces the cytochrome P450 isoenzyme CYP3A4 and P-glycoprotein, which are both involved in the metabolism of irinotecan | Effects of St John's wort on irinotecan metabolism |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category
| Toxicity | Source |
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