| Drug Name: | Lamotrigine (84057-84-1) |
|---|---|
| PubChem ID: | 3878 |
| SMILES: | C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N |
| InchiKey: | PYZRQGJRPPTADH-UHFFFAOYSA-N |
| Therapeutic Category: | Anticonvulsants, Calcium Channel Blockers, Cardiovascular Agents, Central Nervous System Agents, Excitatory Amino Acid Agents, Excitatory Amino Acid Antagonists, Membrane Transport Modulators, Neurotransmitter Agents, Sodium Channel Blockers, Voltage-Gated Sodium Channel Blockers |
| Molecular Weight (dalton) | : | 256.096 |
| LogP | : | 2.0098 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 90.71 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Carbamazepine (298-46-4) | Diplopia | Synergistic | lamotrigine increases the carbamazepine-10,11-epoxide serum levels. Carbamazepine may induce the lucuronidation of lamotrigine | Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction? |
| Rifampicin (13292-46-1) | Decreased Auc Of Lamotrigine | Antagonistic | Rifampicin increases the loss of lamotrigine from the body, probably by inducing glucuronidation via UDP-glucuronyl transferases | Effects of rifampicin and cimetidine on pharmacokinetics and pharmacodynamics of lamotrigine in healthy subjects |
| Sertraline (79617-96-2) | Confusion | Synergistic | sertraline may competitively inhibit the glucuronidation of lamotrigine | Lamotrigine toxicity secondary to sertraline |
| Valproic Acid (99-66-1) | Ataxia | Synergistic | valproate reduces lamotrigine glucuronidation by competitive inhibition, which results in a decreased lamotrigine clearance | Sodium valproate acutely inhibits lamotrigine metabolism |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category