This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Apoptosis | wild-type p53 (P00062) | Menadione at 1-20 microM induced wild-type P53,and thus Apoptosis induced by lower concentrations of menadione may be mediated by wild-type P53. [ ADR Type 1 ] | Menadione induces both necrosis and apoptosis in rat pancreatic acinar AR4-2J cells
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| Morphological Changes | Beta-2-microglobulin (P61769) | Immunocytochemical investigations performed on menadione-exposed cells revealed that some surface proteins (collagen IV@ sialo-proteins@ beta 2 microglobulin and fibronectin) and adhesion molecules (vinculin) underwent changes in their expression over the bleb surface@which demonstrate that cytoskeletal structures and the microfilament system in particular@represent important targets in menadione-induced morphological changes in cultured cells. [ ADR Type 5 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
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| Morphological Changes | Collagen alpha-1(IV) (P02462) | Immunocytochemical investigations performed on menadione-exposed cells revealed that some surface proteins (collagen IV, sialo-proteins, beta 2 microglobulin and fibronectin) and adhesion molecules (vinculin) underwent changes in their expression over the bleb surface,which demonstrate that cytoskeletal structures and the microfilament system in particular,represent important targets in menadione-induced morphological changes in cultured cells [ ADR Type 5 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
|
| Morphological Changes | Fibronectin (P02751) | Immunocytochemical investigations performed on menadione-exposed cells revealed that some surface proteins (collagen IV, sialo-proteins, beta 2 microglobulin and fibronectin) and adhesion molecules (vinculin) underwent changes in their expression over the bleb surface,which demonstrate that cytoskeletal structures and the microfilament system in particular,represent important targets in menadione-induced morphological changes in cultured cells [ ADR Type 5 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
|
| Morphological Changes | Gamma-tubulin (Q96CW5) | Alpha-actinin@ vimentin and microtubular proteins (tubulin@ MAPs and tau) were detected within the blebs@which demonstrate that cytoskeletal structures and the microfilament system in particular@represent important targets in menadione-induced morphological changes in cultured cells [ ADR Type 2 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
|
| Morphological Changes | Methionine aminopeptidase (P53582) | Alpha-actinin@ vimentin and microtubular proteins (tubulin@ MAPs and tau) were detected within the blebs@which demonstrate that cytoskeletal structures and the microfilament system in particular@represent important targets in menadione-induced morphological changes in cultured cells. [ ADR Type 2 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
|
| Morphological Changes | sialo-proteins (P00052) | Immunocytochemical investigations performed on menadione-exposed cells revealed that some surface proteins (collagen IV, sialo-proteins, beta 2 microglobulin and fibronectin) and adhesion molecules (vinculin) underwent changes in their expression over the bleb surface,which demonstrate that cytoskeletal structures and the microfilament system in particular,represent important targets in menadione-induced morphological changes in cultured cells. [ ADR Type 5 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
|
| Morphological Changes | Vimentin (P08670) | Different behavioural characteristics of actin microfilaments@ vimentin and keratin intermediate filaments and microtubules was observed@which demonstrate that cytoskeletal structures and the microfilament system in particular@represent important targets in menadione-induced morphological changes in cultured cells [ ADR Type 2 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
|
| Morphological Changes | Vinculin (P18206) | Different behavioural characteristics of actin microfilaments@ vimentin and keratin intermediate filaments and microtubules was observed@which demonstrate that cytoskeletal structures and the microfilament system in particular@represent important targets in menadione-induced morphological changes in cultured cells [ ADR Type 2 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation
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