This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
| Isoniazid (54-85-3) | Hepatotoxicity | Additive | Not understood | A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers
|
| Azithromycin (83905-01-5) | Neutropenia | Additive | Rifabutin is enzyme inducers, which can increase the metabolism of other drugs by the liver, thereby reducing their serum levels.Rifabutin is also a substrate for cytochrome P450 isoenzyme CYP3A4. It has been suggested that lower body weight and concurrent clarithromycin may result in toxic rifabutin serum levels | Comparison of azithromycin and clarithromycin in their interactions with rifabutin in healthy volunteers
|
| Clarithromycin (81103-11-9) | Neutropenia | Additive | Rifabutin is enzyme inducers, which can increase the metabolism of other drugs by the liver, thereby reducing their serum levels.Rifabutin is also a substrate for cytochrome P450 isoenzyme CYP3A4. It has been suggested that lower body weight and concurrent clarithromycin may result in toxic rifabutin serum levels | Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers
|
| Clarithromycin (81103-11-9) | Uveitis | Additive | Rifabutin is enzyme inducers, which can increase the metabolism of other drugs by the liver, thereby reducing their serum levels.Rifabutin is also a substrate for cytochrome P450 isoenzyme CYP3A4. It has been suggested that lower body weight and concurrent clarithromycin may result in toxic rifabutin serum levels | Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers
|
| Dapsone (80-08-0) | Methaemoglobinaemia | Antagonistic | rifabutin increase the metabolism and clearance of dapsone rifabutin increased the formation of this metabolite, although increases in the AUC were not seen | The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283)
|
| Itraconazole (84625-61-6) | Uveitis | Synergistic | Rifabutin increases the metabolism of itraconazole probably, at least in part, by inducing their metabolism by the cytochrome P450 CYP3A subfamily | Rifabutin prophylaxis and uveitis
|