InAADR

Drug Information

Drug Name: Astemizole (68844-77-9)
PubChem ID: 2247
SMILES: COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
InchiKey: GXDALQBWZGODGZ-UHFFFAOYSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 458.581
LogP: 5.3513
Ring Count: 4
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 42.32

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Ketoconazole (65277-42-1) Torsade De Pointes Synergistic In vitro studies have shown that ketoconazole inhibits the metabolism of astemizole. Combined use of astemizole and ketoconazole resulting in torsade de pointes
Quinine (130-95-0) Arrhythmia Synergistic Uncertain Quinine may trigger torsades de pointes during astemizole therapy

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Arrhythmias Potassium voltage-gated channel subfamily H member 2 (Q12809) Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

InAADR: Drug-Protein-ADRs database