| Drug Name: | Piperacillin (66258-76-2) |
|---|---|
| PubChem ID: | 43672 |
| SMILES: | CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O |
| InchiKey: | IVBHGBMCVLDMKU-GXNBUGAJSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 517.564 |
| LogP | : | -0.2403 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 7 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 156.43 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Gentamicin (1403-66-3) | Nephrotoxicity | Antagonistic | The nephrotoxic effects of gentamicin is well documented. The reason why piperacillin increase the risk of nephrotoxicity is not clear. One suggestion is that sodium loading may protect the kidney from tobramycin toxicity and piperacillin has only 40% as much sodium | Gentamicin inactivation by piperacillin or carbenicillin in patients with end-stage renal disease |
| Tobramycin (32986-56-4) | Nephrotoxicity | Antagonistic | The nephrotoxic effects of tobramicin is well documented. The reason why piperacillin increase the risk of nephrotoxicity is not clear. One suggestion is that sodium loading may protect the kidney from tobramycin toxicity and piperacillin has only 40% as much sodium | In vivo inactivation of tobramycin by piperacillin |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category