This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Cerebrovascular Disease | NMDA receptor-regulated protein (Q9BXJ9) | Hcy@which is formed by demethylation of methionine@exerts a toxic action on neuronal cells trough the stimulation of N-methyl-D-aspartate (NMDA) receptors@which contribute to the cognitive changes and markedly increased risk of cerebrovascular disease in children and young adults with homocystunuria [ ADR Type 1 ] | Hyperhomocysteinemia: atherothrombosis and neurotoxicity
|
| Lipoprotein Peroxidation | Methylenetetrahydrofolate reductase (P42898) | Genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels@which could lead to the pathogenesis of Hcy(formed by demethylation of methionine)-induced vascular damage may be multifactorial@ including direct Hcy damage to the endothelium@ stimulation of proliferation of smooth muscle cells@ enhanced low-density lipoprotein peroxidation@ increase of platelet aggregation@ and effects on the coagulation system. [ ADR Type 3 ] | Hyperhomocysteinemia: atherothrombosis and neurotoxicity
|
| Platelet Aggregation | Cystathionine beta-synthase (P35520) | Genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels@which could lead to the pathogenesis of Hcy(formed by demethylation of methionine)-induced vascular damage may be multifactorial@ including direct Hcy damage to the endothelium@ stimulation of proliferation of smooth muscle cells@ enhanced low-density lipoprotein peroxidation@ increase of platelet aggregation@ and effects on the coagulation system. [ ADR Type 3 ] | Hyperhomocysteinemia: atherothrombosis and neurotoxicity
|
| Platelet Aggregation | Methylenetetrahydrofolate reductase (P42898) | Genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels@which could lead to the pathogenesis of Hcy(formed by demethylation of methionine)-induced vascular damage may be multifactorial@ including direct Hcy damage to the endothelium@ stimulation of proliferation of smooth muscle cells@ enhanced low-density lipoprotein peroxidation@ increase of platelet aggregation@ and effects on the coagulation system. [ ADR Type 3 ] | Hyperhomocysteinemia: atherothrombosis and neurotoxicity
|
This panel provides drug-food interactions and their ADRs along with references
This panel provides information on drug category