| Drug Name: | Hydrochlorothiazide (58-93-5) |
|---|---|
| PubChem ID: | 3639 |
| SMILES: | C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl |
| InchiKey: | JZUFKLXOESDKRF-UHFFFAOYSA-N |
| Therapeutic Category: | Antihypertensive Agents, Cardiovascular Agents, Diuretics, Membrane Transport Modulators, Natriuretic Agents, Sodium Chloride Symporter Inhibitors |
| Molecular Weight (dalton) | : | 297.745 |
| LogP | : | -0.3513 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 118.36 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Dofetilide (115256-11-6) | Increase In The Qt Interval | Additive | Hydrochlorothiazide should increase dofetilide levels is unclear. An increase in dofetilide levels would be expected to increase the QT interval, but the increase seen here was much greater than expected by the change in plasma levels | Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil |
| Amantadine (768-94-5) | Agitation | Synergistic | Uncertain | Amantadine-dyazide interaction |
| Amantadine (768-94-5) | Ataxia | Synergistic | Uncertain | Amantadine-dyazide interaction |
| Amantadine (768-94-5) | Hallucinations | Synergistic | Uncertain | Amantadine-dyazide interaction |
This panel provides drug-protein interaction and their ADRs along with references
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category