| Drug Name: | Prochlorperazine (58-38-8) |
|---|---|
| PubChem ID: | 4917 |
| SMILES: | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl |
| InchiKey: | WIKYUJGCLQQFNW-UHFFFAOYSA-N |
| Therapeutic Category: | Antiemetics, Antipsychotic Agents, Autonomic Agents, Central Nervous System Agents, Central Nervous System Depressants, Dopamine Agents, Dopamine Antagonists, Gastrointestinal Agents, Neurotransmitter Agents, Peripheral Nervous System Agents, Psychotropic Drugs, Tranquilizing Agents |
| Molecular Weight (dalton) | : | 373.953 |
| LogP | : | 4.5802 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 9.72 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Levodopa (59-92-7) | Decrease The Effect Of Levodopa | Antagonistic | Phenothiazines block the dopamine receptors in the brain and can therefore upset the balance between cholinergic and dopaminergic components within the striatum and substantia nigra | Long-term treatment of Parkinson's disease with levodopa |
| Procarbazine (671-16-9) | Dystonic Reaction | Synergistic | Prochlorperazine was thought to have contributed to the sedative effects of procarbazine | Procarbazine-prochlorperazine interaction: an underreported phenomenon |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Disruption Of The Structural Organization | Glucose-6-phosphatase (P35575) | Prochlorperazine disrupts the structural organization between lipids and proteins in microsomal membranes@ altering thereby the activity and regulation of at least two different integral membrane proteins. [ ADR Type 2 ] | Effects of prochlorperazine on the function of integral membrane proteins |
| Disruption Of The Structural Organization | UDP-glucuronosyltransferase (P22309) | Prochlorperazine disrupts the structural organization between lipids and proteins in microsomal membranes@ altering thereby the activity and regulation of at least two different integral membrane proteins [ ADR Type 2 ] | Effects of prochlorperazine on the function of integral membrane proteins |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category