InAADR

Drug Information

Drug Name: Ethinyl Estradiol (57-63-6)
PubChem ID: 5991
SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O
InchiKey: BFPYWIDHMRZLRN-SLHNCBLASA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 296.41
LogP: 3.6126
Ring Count: 1
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 40.46

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Minocycline (10118-90-8) Melasma Additive Not understood. It seems possible that the facial pigmentation (melasma, chloasma) that can occur with oral contraceptives may have been additive with the effects of the minocycline Minocycline-induced pigmentation occurring in two sisters

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Amenorrhoea Neuropeptide S receptor (Q6W5P4) Not Available Large-scale prediction and testing of drug activity on side-effect targets
Hepatotoxicity CYP2B protein (Q14097) PXR is involved in the induction of CYP3A23 by pharmacologically and structurally distinct steroids and xenobiotics Moreover@ PXR-mediated PCB activation of the (CYP3A23)2-tk-CAT may serve as a rapid assay for effects of nonplanar PCBs [ ADR Type 2 ] Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
Hepatotoxicity Cytochrome P450 3A4 (P08684) PXR is involved in the induction of CYP3A23 by pharmacologically and structurally distinct steroids and xenobiotics. Moreover@ PXR-mediated PCB activation of the (CYP3A23)2-tk-CAT may serve as a rapid assay for effects of nonplanar PCBs. [ ADR Type 2 ] Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
Hepatotoxicity Heparin secretory transforming protein(HST) (P08620) Associated with idiosyncratic hepatotoxicity [ ADR Type 2 ] Identification of 3 alpha-hydroxy-cyproterone acetate as a metabolite of cyproterone acetate in the bile of female rats and the potential of this and other already known or putative metabol
Hypertension Neuropeptide S receptor (Q6W5P4) Not Available Large-scale prediction and testing of drug activity on side-effect targets
Pancreatic Disorder D(3) dopamine receptor (P35462) Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Venous Thrombosis Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Acne ADReCS
Acne Vulgaris MetaADEDB
Adenocarcinoma MetaADEDB
Adenoma Liver Cell MetaADEDB
Adrenal Insufficiency MetaADEDB
Adrenocortical Hyperfunction MetaADEDB
Alopecia ADReCS
Amenorrhea MetaADEDB
Amenorrhoea ADReCS
Anemia Macrocytic MetaADEDB
Anger PROTECT
Angioedema ADReCS
Anorexia MetaADEDB
Anxiety Disorder PROTECT
Appetite Disorder ADReCS
Application Site Abscess PROTECT
Application Site Erosion PROTECT
Application Site Erythema PROTECT
Application Site Irritation PROTECT
Application Site Pustules PROTECT
Application Site Rash PROTECT
Arterial Occlusive Diseases MetaADEDB
Arteriosclerosis MetaADEDB
Arthritis Experimental MetaADEDB
Atrial Septal Defect 2 MetaADEDB
Blood Glucose Abnormal PROTECT
Brain Ischemia MetaADEDB
Breast Cancer PROTECT
Breast Discharge ADReCS
Breast Diseases MetaADEDB
Breast Enlargement ADReCS
Breast Tenderness ADReCS
Budd-Chiari Syndrome ADReCS
Carbohydrate Tolerance Decreased ADReCS
Carcinoma Hepatocellular MetaADEDB
Cardiovascular Diseases MetaADEDB
Cataract ADReCS
Cerebral Haemorrhage ADReCS
Cerebral Infarction MetaADEDB
Cerebral Thrombosis ADReCS
Cervical Discharge ADReCS
Cervical Dysplasia PROTECT
Cervix Carcinoma PROTECT
Cholestasis MetaADEDB
Cholestasis Intrahepatic MetaADEDB
Colitis ADReCS
Contact Lens Intolerance ADReCS
Corneal Disorder ADReCS
Coronary Occlusion MetaADEDB
Cystitis MetaADEDB
Cystitis-Like Symptom ADReCS
Depression ADReCS
Depressive Disorder MetaADEDB
Dermatitis Allergic PROTECT
Diarrhea MetaADEDB
Disorders Of Sex Development MetaADEDB
Dizziness ADReCS
Dysmenorrhea MetaADEDB
Dyspepsia MetaADEDB
Ear Neoplasms MetaADEDB
Eating Disorders MetaADEDB
Ebstein Anomaly MetaADEDB
Edema MetaADEDB
Embolism Arterial ADReCS
Encephalomyelitis Autoimmune Experimental MetaADEDB
Endometrial Neoplasms MetaADEDB
Erythema Multiforme ADReCS
Erythema Nodosum ADReCS
Exfoliative Rash PROTECT
Fatigue MetaADEDB
Fatty Liver MetaADEDB
Feminization MetaADEDB
Folic Acid Deficiency MetaADEDB
Frustration PROTECT
Gallbladder Diseases MetaADEDB
Gallbladder Disorder ADReCS
Gallbladder Neoplasms MetaADEDB
Gastrointestinal Disorder ADReCS
Gynecomastia MetaADEDB
Haemolytic Uraemic Syndrome ADReCS
Haemorrhage ADReCS
Headache ADReCS
Heart Diseases MetaADEDB
Heart Failure MetaADEDB
Heart Septal Defects Ventricular MetaADEDB
Hepatic Adenoma ADReCS
Hepatic Lesion PROTECT
Hirsutism ADReCS
Hot Flashes MetaADEDB
Hyperplasia MetaADEDB
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertension Malignant MetaADEDB
Hypertension Renovascular MetaADEDB
Hypertrophy Left Ventricular MetaADEDB
Hypocalcemia MetaADEDB
Hypospadias MetaADEDB
Infertility ADReCS
Infertility Female MetaADEDB
Infertility Male MetaADEDB
Intestinal Neoplasms MetaADEDB
Intracranial Embolism And Thrombosis MetaADEDB
Jaundice Cholestatic ADReCS
Jaundice Obstructive MetaADEDB
Lactation Disorders MetaADEDB
Libido Disorder ADReCS
Lipids Abnormal PROTECT
Liver Neoplasms MetaADEDB
Liver Neoplasms Experimental MetaADEDB
Melanosis MetaADEDB
Melasma ADReCS
Menstrual Disorder ADReCS
Mesothelioma MetaADEDB
Metrorrhagia ADReCS
Migraine ADReCS
Mood Disorders MetaADEDB
Myocardial Infarction ADReCS
Myocardial Ischemia MetaADEDB
Nausea ADReCS
Nervousness ADReCS
Oedema ADReCS
Pain MetaADEDB
Pancreatic Neoplasms MetaADEDB
Panic Disorder MetaADEDB
Polycystic Ovary Syndrome MetaADEDB
Porphyria ADReCS
Precancerous Conditions MetaADEDB
Premenstrual Syndrome ADReCS
Prenatal Exposure Delayed Effects MetaADEDB
Prolactinoma MetaADEDB
Prostatic Diseases MetaADEDB
Prostatic Hyperplasia MetaADEDB
Prostatic Neoplasms MetaADEDB
Pruritus MetaADEDB
Psychotic Disorders MetaADEDB
Pulmonary Artery Thrombosis PROTECT
Pulmonary Embolism ADReCS
Rash ADReCS
Rash Pruritic PROTECT
Renal Impairment ADReCS
Retinal Vascular Thrombosis ADReCS
Sexual And Gender Disorders MetaADEDB
Sinus Thrombosis Intracranial MetaADEDB
Skin Ulcer MetaADEDB
Sleep Initiation And Maintenance Disorders MetaADEDB
Spermatocele MetaADEDB
Stroke MetaADEDB
Substance Withdrawal Syndrome MetaADEDB
Suppressed Lactation ADReCS
Tachycardia MetaADEDB
Taste Disorders MetaADEDB
Tetany MetaADEDB
Thromboangiitis Obliterans MetaADEDB
Thromboembolism MetaADEDB
Thrombophilia MetaADEDB
Thrombophlebitis ADReCS
Thrombosis MetaADEDB
Thrombosis Mesenteric Vessel ADReCS
Tricuspid Atresia MetaADEDB
Urethral Stricture MetaADEDB
Urinary Bladder Neoplasms MetaADEDB
Urogenital Abnormalities MetaADEDB
Urticaria ADReCS
Uterine Cervical Erosion ADReCS
Uterine Neoplasms MetaADEDB
Uterine Spasm PROTECT
Vaginal Infection ADReCS
Venous Thromboembolism MetaADEDB
Venous Thrombosis ADReCS
Ventricular Fibrillation MetaADEDB
Vision Disorders MetaADEDB
Vomiting ADReCS
Vulvovaginal Candidiasis ADReCS
Weight Fluctuation ADReCS
Weight Gain MetaADEDB
Xanthomatosis MetaADEDB

InAADR: Drug-Protein-ADRs database