| Drug Name: | Thiothixene (5591-45-7) |
|---|---|
| PubChem ID: | 941651 |
| SMILES: | CN1CCN(CC1)CC/C=C2/C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C |
| InchiKey: | GFBKORZTTCHDGY-UWVJOHFNSA-N |
| Therapeutic Category: | Antipsychotic Agents, Central Nervous System Agents, Central Nervous System Depressants, Dopamine Agents, Dopamine Antagonists, Neurotransmitter Agents, Psychotropic Drugs, Tranquilizing Agents |
| Molecular Weight (dalton) | : | 443.638 |
| LogP | : | 3.4707 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 43.86 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Parkinsonism | NADH-ubiquinone oxidoreductase chain 1 (P03886) | Thiothixene produces parkinsonism apparently through inhibition of NADH:ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain [ ADR Type 1 ] | Neuroleptic medications inhibit complex I of the electron transport chain |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category