| Drug Name: | Flecainide (54143-55-4) |
|---|---|
| PubChem ID: | 3356 |
| SMILES: | C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F |
| InchiKey: | DJBNUMBKLMJRSA-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-Arrhythmia Agents, Cardiovascular Agents, Membrane Transport Modulators, Sodium Channel Blockers, Voltage-Gated Sodium Channel Blockers |
| Molecular Weight (dalton) | : | 414.346 |
| LogP | : | 3.4407 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 59.59 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Amiodarone (1951-25-3) | Torsade De Pointes | Synergistic | Amiodarone inhibits the cytochrome P450 isoenzyme CYP2D6, so that the flecainide is metabolised by the liver more slowly. Amiodarone also inhibits CYP2D6-independent mechanisms of flecainide elimination | Flecainide and amiodarone interaction |
| verapamil (52-53-9) | Asystole | Additive | Flecainide and verapamil have little or no effects on the pharmacokinetics of each other, but they can apparently have additive depressant effects on the heart | Asystole and cardiogenic shock due to combined treatment with verapamil and flecainide |
This panel provides drug-protein interaction and their ADRs along with references
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category