InAADR

Drug Information

Drug Name: Loperamide (53179-11-6)
PubChem ID: 3955
SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
InchiKey: RDOIQAHITMMDAJ-UHFFFAOYSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 477.048
LogP: 5.088
Ring Count: 3
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 43.78

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Cramp ADReCS
Abdominal Cramp SIDER
Abdominal Distension SIDER
Abdominal Distension ADReCS
Abdominal Pain SIDER
Abdominal Pain ADReCS
Abnormal Dreams MetaADEDB
Abnormal Faeces MetaADEDB
Acidosis MetaADEDB
Acne MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Kidney Failure MetaADEDB
Adenocarcinoma MetaADEDB
Adenopathy MetaADEDB
Aggression MetaADEDB
Allergic Reaction ADReCS
Alopecia MetaADEDB
Alpha Haemolytic Streptococcal Infection MetaADEDB
Altered State Of Consciousness ADReCS
Anaemia MetaADEDB
Anal Cancer MetaADEDB
Anaphylactic Shock ADReCS
Anaphylactoid Reaction ADReCS
Angina Unstable MetaADEDB
Angioedema ADReCS
Anhedonia MetaADEDB
Anorexia MetaADEDB
Appendicitis MetaADEDB
Arrhythmia MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthritis MetaADEDB
Ascites MetaADEDB
Asthenia ADReCS
Atrial Tachycardia MetaADEDB
Bacterial Sepsis MetaADEDB
Bacterial Toxaemia MetaADEDB
Balance Disorder MetaADEDB
Black Stools MetaADEDB
Bladder Inflammation MetaADEDB
Bleb MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Amylase Decreased MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood Creatine Phosphokinase Mb Abnormal MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Glucose Decreased MetaADEDB
Blood Iron Decreased MetaADEDB
Blood Magnesium Decreased MetaADEDB
Blood Sodium MetaADEDB
Body Temperature Increased MetaADEDB
Bowel Sounds Abnormal MetaADEDB
Breast Disorder MetaADEDB
Breast Tenderness MetaADEDB
Bronchomalacia MetaADEDB
Bruise MetaADEDB
Bullous Eruption ADReCS
Bunion MetaADEDB
Cachectic MetaADEDB
Candida Infection MetaADEDB
Candidiasis Of Mouth MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiopulmonary Failure MetaADEDB
Catheter Site Pain MetaADEDB
Cerebral Thrombosis MetaADEDB
Chill MetaADEDB
Choking Sensation MetaADEDB
Chronic Graft Versus Host Disease MetaADEDB
Cirrhosis MetaADEDB
Clostridial Infection MetaADEDB
Cognitive Disorder MetaADEDB
Cold Extremities MetaADEDB
Colitis MetaADEDB
Colitis Ischaemic MetaADEDB
Colitis Ulcerative MetaADEDB
Complications Of Transplanted Kidney MetaADEDB
Computerised Tomogram MetaADEDB
Confabulation MetaADEDB
Congenital Heart Disease MetaADEDB
Congenital Tracheomalacia MetaADEDB
Conjunctival Deposit MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Corneal Disorder MetaADEDB
Coronary Artery Stenosis MetaADEDB
Crackles Lung MetaADEDB
Cramp Muscle SIDER
Crohn Disease MetaADEDB
Csf Lymphocyte Count Increased MetaADEDB
Culture Positive MetaADEDB
Cyanosis MetaADEDB
Cytolytic Hepatitis MetaADEDB
Deafness Congenital MetaADEDB
Death MetaADEDB
Deglutition Disorder MetaADEDB
Dehydration MetaADEDB
Delirium MetaADEDB
Dental Alveolar Anomaly MetaADEDB
Depressed Level Of Consciousness ADReCS
Depressed Mood MetaADEDB
Depression Suicidal MetaADEDB
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Dermatitis Exfoliative MetaADEDB
Diarrhea MetaADEDB
Discomfort ADReCS
Disorder Lung MetaADEDB
Distention SIDER
Dizziness ADReCS
Drowsiness SIDER
Drug Interaction Potentiation MetaADEDB
Drug Toxicity MetaADEDB
Dry Mouth ADReCS
Duodenal Ulcer MetaADEDB
Dyspepsia ADReCS
Dysphonia MetaADEDB
Ear Injury MetaADEDB
Ebv Infection MetaADEDB
Ecg Signs Of Ventricular Hypertrophy MetaADEDB
Electrolyte Disorder MetaADEDB
Emesis MetaADEDB
Emotional Distress MetaADEDB
Enlarged Spleen MetaADEDB
Enteritis MetaADEDB
Enteritis Infectious MetaADEDB
Eruption SIDER
Erythema ADReCS
Erythema Multiforme ADReCS
Escherichia Infection MetaADEDB
Excess Potassium MetaADEDB
Exomphalos MetaADEDB
Eyelid Retraction MetaADEDB
Fatigue ADReCS
Fatty Stools MetaADEDB
Febrile Neutropenia MetaADEDB
Feeling Guilty MetaADEDB
Flank Pain MetaADEDB
Flatulence ADReCS
Gamma-Glutamyltransferase Increased MetaADEDB
Gas Gangrene MetaADEDB
Gastroenteritis MetaADEDB
Gastrointestinal Disorder SIDER
Gastrointestinal Pain ADReCS
Genital Erosion MetaADEDB
Haematoma Evacuation MetaADEDB
Haemorrhage Rectum MetaADEDB
Haemorrhoids MetaADEDB
Headache ADReCS
Heart Rate Increased MetaADEDB
Heat Stroke MetaADEDB
Helicobacter Infection MetaADEDB
Henoch-Schonlein Purpura MetaADEDB
Hepatitis C MetaADEDB
Hernia ADReCS
Hidradenitis MetaADEDB
Hiv Disease MetaADEDB
Hyperchloraemia MetaADEDB
Hyperlipaemia MetaADEDB
Hyperreflexia MetaADEDB
Hypersensitivity ADReCS
Hypokalaemia MetaADEDB
Hypomania MetaADEDB
Hypoproteinaemia MetaADEDB
Ild MetaADEDB
Ileus ADReCS
Ileus Paralytic ADReCS
Immune System Disorder SIDER
Increased Appetite MetaADEDB
Infantile Spasms MetaADEDB
Infection MetaADEDB
Infection Urinary Tract MetaADEDB
Inflammatory Bowel Disease MetaADEDB
Infusion Site Pruritus MetaADEDB
International Normalised Ratio Increased MetaADEDB
Intestinal Anastomosis Complication MetaADEDB
Intestinal Mass MetaADEDB
Intestinal Obstruction MetaADEDB
Intestinal Perforation MetaADEDB
Joint Contracture MetaADEDB
Kidney Failure MetaADEDB
Laryngomalacia MetaADEDB
Leukopenia Neonatal MetaADEDB
Lice Infestation MetaADEDB
Lip Erosion MetaADEDB
Livedo Reticularis MetaADEDB
Loss Of Consciousness ADReCS
Loss Of Weight MetaADEDB
Lung Infection MetaADEDB
Lymphocytes Decreased MetaADEDB
Lymphoma MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Malnourished MetaADEDB
Mechanical Ventilation MetaADEDB
Mediastinal Mass MetaADEDB
Megacolon ADReCS
Megacolon Toxic ADReCS
Mental Status Changes MetaADEDB
Mesothelioma Malignant Advanced MetaADEDB
Mouth Ulcer MetaADEDB
Mucosal Dryness MetaADEDB
Mucosal Erosion MetaADEDB
Mucosal Inflammation MetaADEDB
Multiple Drug Overdose MetaADEDB
Multiple Drug Overdose Intentional MetaADEDB
Muscle Spasms ADReCS
Nail Tinea MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Necrolysis Epidermal SIDER
Negative Thoughts MetaADEDB
Neoplasm Progression MetaADEDB
Nephrolithiasis MetaADEDB
Nervous System Diseases MetaADEDB
Nervous System Disorder SIDER
Nervous Tension MetaADEDB
Neumonia MetaADEDB
Neutropenic Sepsis MetaADEDB
Nikolsky Sign MetaADEDB
Non-Small Cell Lung Cancer MetaADEDB
Oculomucocutaneous Syndrome MetaADEDB
Oliguria MetaADEDB
Overgrowth Bacterial MetaADEDB
Oxygen Consumption Decreased MetaADEDB
Pain ADReCS
Pancreatic Insufficiency MetaADEDB
Pancreatitis MetaADEDB
Patent Ductus Arteriosis MetaADEDB
Pelvic Mass MetaADEDB
Peritoneal Carcinoma MetaADEDB
Persistent Foetal Circulation MetaADEDB
Pharyngolaryngeal Discomfort MetaADEDB
Pitting Oedema MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pneumonia Klebsiella MetaADEDB
Polyp MetaADEDB
Polyuria MetaADEDB
Portal Venous Gas MetaADEDB
Post Inflammatory Pigmentation Change MetaADEDB
Post Nasal Drip MetaADEDB
Prostatitis MetaADEDB
Protein Total Decreased MetaADEDB
Pruritus ADReCS
Pulmonary Arrest MetaADEDB
Rash ADReCS
Rash Generalised MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Rate Increased MetaADEDB
Right Heart Failure MetaADEDB
Right Ventricular Hypertrophy MetaADEDB
Sarcoidosis MetaADEDB
Scotoma MetaADEDB
Seizures MetaADEDB
Sensation Of Foreign Body MetaADEDB
Shock ADReCS
Sinus Headache MetaADEDB
Sinusitis MetaADEDB
Skin Hypertrophy MetaADEDB
Skin Induration MetaADEDB
Skin Tightness MetaADEDB
Sleep Apnea MetaADEDB
Small Intestinal Obstruction MetaADEDB
Somnolence ADReCS
Sputum Discoloured MetaADEDB
Sputum Purulent MetaADEDB
Staphylococcal Infection MetaADEDB
Stasis Dermatitis MetaADEDB
Stevens-Johnson Syndrome ADReCS
Supraventricular Tachyarrhythmia MetaADEDB
Swollen Tongue MetaADEDB
Thymic Cancer Metastatic MetaADEDB
Tongue Cyst MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Tracheal Disorder MetaADEDB
Tracheostomy Malfunction MetaADEDB
Treatment Noncompliance MetaADEDB
Tumour Lysis Syndrome MetaADEDB
Unconsciousness MetaADEDB
Urethral Disorder SIDER
Urinary Retention ADReCS
Urinary Tract Disorder SIDER
Urticaria ADReCS
Venous Insufficiency MetaADEDB
Vomiting ADReCS
Walking Disability MetaADEDB
Warm Type Haemolytic Anaemia MetaADEDB
Xerosis MetaADEDB

InAADR: Drug-Protein-ADRs database