| Drug Name: | Cephaloridine (50-59-9) |
|---|---|
| PubChem ID: | 5773 |
| SMILES: | C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4 |
| InchiKey: | CZTQZXZIADLWOZ-CRAIPNDOSA-N |
| Therapeutic Category: | Anti-Bacterial Agents, Anti-Infective Agents |
| Molecular Weight (dalton) | : | 415.496 |
| LogP | : | -0.3178 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 93.42 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Furosemide (54-31-9) | Nephrotoxicity | Antagonistic | Cefaloridine is nephrotoxic, but why this should be increased by furosemide is not understood. It may possibly be related to a reduction in its clearance | Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine |
| Probenecid (57-66-9) | Nephrotoxicity | Antagonistic | Probenecid inhibits the excretion of most cephalosporins by the kidney tubules by successfully competing for the excretory mechanisms. Thus the cephalosporin is retained in the body and its serum levels rise. The extent of the rise cannot always be fully accounted for by this mechanism alone and it is suggested that some change in tissue distribution may sometimes have a part to play. | Probenecid: an unexplained effect on cephalosporin pharmacology |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Impair Antioxidant Status | Glutathione peroxidase 1 (P07203) | Selenium deficiency impaired antioxidant status and enhanced cephaloridine-induced injury [ ADR Type 3 ] | Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats |
| Nephrotoxicity | Glutathione peroxidase 1 (P07203) | Selenium deficiency potentiated cephaloridine nephrotoxicity [ ADR Type 3 ] | Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category