This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Atherogenesis | Orphan nuclear receptor NR4A3 (Q92570) | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to atherogenesis [ ADR Type 2 ] | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
|
| Cell Proliferation | Orphan nuclear receptor NR4A3 (Q92570) | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to cell proliferation and differentiation [ ADR Type 2 ] | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
|
| Chondrosarcomas | Orphan nuclear receptor NR4A3 (Q92570) | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to chondrosarcomas [ ADR Type 2 ] | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
|
| Inflammation | Orphan nuclear receptor NR4A3 (Q92570) | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to inflammation. [ ADR Type 2 ] | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
|
| Myelotoxicity | Thiopurine S-methyltransferase (P51580) | Myelotoxicity [ ADR Type 2 ] | Pharmacogenetics in cancer chemotherapy: balancing toxicity and response
|
| Neurological Disorders | Orphan nuclear receptor NR4A3 (Q92570) | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to neurological disorders [ ADR Type 2 ] | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
|
| T-Cell Apoptosis | Orphan nuclear receptor NR4A3 (Q92570) | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation@ coactivator recruitment@ and activation by the purine anti-metabolite 6-mercaptopurine@ which leads to T-cell apoptosis [ ADR Type 2 ] | The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
|