| Drug Name: | Hydrocortisone (50-23-7) |
|---|---|
| PubChem ID: | 5754 |
| SMILES: | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O |
| InchiKey: | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| Therapeutic Category: | Anti-Inflammatory Agents |
| Molecular Weight (dalton) | : | 362.466 |
| LogP | : | 1.7816 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 94.83 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Amphotericin B (1397-89-3) | Cardiac Function Failure | Synergistic | Amphotericin B causes potassium to be lost in the urine. Hydrocortisone can cause potassium to be lost, and salt and water to be retained, and occasional instances of hypernatraemia with amphotericin B have also been seen. Working in concert these could account for the hypokalaemic cardiopathy and the circulatory overload that was seen | Reversible cardiac enlargement during treatment with amphotericin B and hydrocortisone Report of three cases |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Depression | Neuropeptide S receptor (Q6W5P4) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
| Inflammation | Interleukin-8 (P10145) | Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production@which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation [ ADR Type 1 ] | Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category