InAADR

Drug Information

Drug Name: Mitomycin (50-07-7)
PubChem ID: 5746
SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
InchiKey: NWIBSHFKIJFRCO-WUDYKRTCSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 334.332
LogP: -1.6512
Ring Count: 0
Hydrogen Bond Acceptor Count: 8
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 146.89

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Fluorouracil (51-21-8) Haemolysis Synergistic Not known Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C
Fluorouracil (51-21-8) Renal Impairment Synergistic Not known Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C
Spironolactone (52-01-7) Diarrhoea Antagonistic Not understood Mitotane Spironolactone antagonism in Cushing's syndrome
Spironolactone (52-01-7) Nausea Antagonistic Not understood Mitotane Spironolactone antagonism in Cushing's syndrome
Tamoxifen (10540-29-1) Haemolytic Anaemia Synergistic haemolytic uraemic syndrome was due to a combination of subclinical endothelial damage induced by mitomycin C, and a thrombotic effect on platelets caused by tamoxifen. A toxic interaction between mitomycin C and tamoxifen causing the haemolytic uraemic syndrome
Tamoxifen (10540-29-1) Renal Impairment Synergistic haemolytic uraemic syndrome was due to a combination of subclinical endothelial damage induced by mitomycin C, and a thrombotic effect on platelets caused by tamoxifen. A toxic interaction between mitomycin C and tamoxifen causing the haemolytic uraemic syndrome
Tamoxifen (10540-29-1) Thrombocytopenia Synergistic haemolytic uraemic syndrome was due to a combination of subclinical endothelial damage induced by mitomycin C, and a thrombotic effect on platelets caused by tamoxifen. A toxic interaction between mitomycin C and tamoxifen causing the haemolytic uraemic syndrome
Vinblastine (865-21-4) Pulmonary Toxicity Synergistic Not clear Syndrome of acute dyspnea related to combined mitomycin plus vinca alkaloid chemotherapy

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Acute Kidney Injury MetaADEDB
Acute Respiratory Distress Syndrome SIDER
Adenocarcinoma MetaADEDB
Adenocarcinoma Of Lung MetaADEDB
Adult Respiratory Distress Syndrome ADReCS
Alopecia ADReCS
Anaemia ADReCS
Anemia MetaADEDB
Anemia Aplastic MetaADEDB
Anemia Hemolytic MetaADEDB
Anorexia ADReCS
Anuria MetaADEDB
Anus Neoplasms MetaADEDB
Arteritis MetaADEDB
Aspiration ADReCS
Asthenia ADReCS
Ataxia MetaADEDB
Atrophy MetaADEDB
Azotaemia ADReCS
Azotemia MetaADEDB
Bile Duct Diseases MetaADEDB
Bladder Fibrosis ADReCS
Blood Creatinine Increased ADReCS
Body Temperature Increased ADReCS
Bone Marrow Diseases MetaADEDB
Bone Marrow Failure ADReCS
Bone Marrow Toxicity ADReCS
Breast Neoplasms MetaADEDB
Burning Sensation ADReCS
Calcinosis MetaADEDB
Carcinoma MetaADEDB
Carcinoma Non-Small-Cell Lung MetaADEDB
Carcinoma Squamous Cell MetaADEDB
Carcinoma Transitional Cell MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Congestive ADReCS
Carotid Stenosis MetaADEDB
Cataract MetaADEDB
Cellulitis ADReCS
Chest Pain MetaADEDB
Cholecystitis MetaADEDB
Cicatrix MetaADEDB
Colonic Neoplasms MetaADEDB
Colorectal Neoplasms MetaADEDB
Confusional State ADReCS
Conjunctivitis MetaADEDB
Corneal Diseases MetaADEDB
Corneal Dystrophy Avellino Type MetaADEDB
Corneal Edema MetaADEDB
Corneal Opacity MetaADEDB
Corneal Perforation MetaADEDB
Cough ADReCS
Cutaneous Fistula MetaADEDB
Cystitis MetaADEDB
Death ADReCS
Decreased Appetite ADReCS
Demyelinating Diseases MetaADEDB
Dermatitis ADReCS
Diarrhea MetaADEDB
Diarrhoea ADReCS
Discomfort ADReCS
Disease Progression MetaADEDB
Dizziness ADReCS
Drug Hypersensitivity MetaADEDB
Drug Toxicity MetaADEDB
Dry Cough ADReCS
Dyspnoea ADReCS
Ear Diseases MetaADEDB
Edema MetaADEDB
Eosinophilia MetaADEDB
Erythema ADReCS
Esophageal Neoplasms MetaADEDB
Extravasation ADReCS
Extravasation Of Diagnostic And Therapeutic Materials MetaADEDB
Fatigue ADReCS
Feeling Abnormal ADReCS
Fever MetaADEDB
Fibrosis ADReCS
Gastrointestinal Neoplasms MetaADEDB
Glaucoma MetaADEDB
Glaucoma Open-Angle MetaADEDB
Glioblastoma MetaADEDB
Haematemesis ADReCS
Haemolysis ADReCS
Haemolytic Anaemia ADReCS
Haemolytic Uraemic Syndrome ADReCS
Head And Neck Neoplasms MetaADEDB
Headache ADReCS
Heart Failure MetaADEDB
Hematuria MetaADEDB
Hemolysis MetaADEDB
Hemolytic-Uremic Syndrome MetaADEDB
Hemorrhage MetaADEDB
Hepatic Veno-Occlusive Disease MetaADEDB
Hydronephrosis MetaADEDB
Hyperbilirubinemia MetaADEDB
Hyperkalemia MetaADEDB
Hypertension ADReCS
Hypoaldosteronism MetaADEDB
Hypokalemia MetaADEDB
Hyponatremia MetaADEDB
Ileus MetaADEDB
Ill-Defined Disorder ADReCS
Infarction MetaADEDB
Intestinal Fistula MetaADEDB
Iris Diseases MetaADEDB
Iritis MetaADEDB
Kidney Cortex Necrosis MetaADEDB
Kidney Diseases MetaADEDB
Kidney Failure Chronic MetaADEDB
Leukopenia ADReCS
Liver Neoplasms MetaADEDB
Loss Of Consciousness ADReCS
Lung Diseases MetaADEDB
Lung Infiltration ADReCS
Lung Neoplasms MetaADEDB
Malaise ADReCS
Metastatic Disease SIDER
Metastatic Neoplasm ADReCS
Microangiopathic Haemolytic Anaemia ADReCS
Mucositis MetaADEDB
Mucous Membrane Disorder ADReCS
Multiple Organ Failure MetaADEDB
Myelosuppression SIDER
Nausea ADReCS
Necrosis ADReCS
Neoplasm Malignant ADReCS
Neoplasm Metastasis MetaADEDB
Neoplasms MetaADEDB
Nephropathy Toxic ADReCS
Nervous System Diseases MetaADEDB
Nervous System Disorder ADReCS
Neurotoxicity Syndromes MetaADEDB
Neutropenia MetaADEDB
Ocular Hypotension MetaADEDB
Oedema ADReCS
Oliguria MetaADEDB
Ovarian Neoplasms MetaADEDB
Pain ADReCS
Pallor MetaADEDB
Pancreatic Neoplasms MetaADEDB
Pancytopenia ADReCS
Pelvic Pain MetaADEDB
Photophobia MetaADEDB
Postoperative Complications MetaADEDB
Prostatic Neoplasms MetaADEDB
Pterygium MetaADEDB
Pulmonary Edema MetaADEDB
Pulmonary Oedema ADReCS
Pulmonary Toxicity ADReCS
Pulmonary Veno-Occlusive Disease MetaADEDB
Pupil Disorders MetaADEDB
Purpura Thrombotic Thrombocytopenic MetaADEDB
Pyrexia ADReCS
Rash ADReCS
Rectal Neoplasms MetaADEDB
Recurrence MetaADEDB
Renal Failure ADReCS
Renal Impairment ADReCS
Renal Insufficiency MetaADEDB
Respiratory Distress ADReCS
Retinal Artery Occlusion MetaADEDB
Retinal Vein Occlusion MetaADEDB
Scleral Diseases MetaADEDB
Shock ADReCS
Skin Diseases MetaADEDB
Skin Exfoliation ADReCS
Skin Ulcer MetaADEDB
Somnolence ADReCS
Stomach Neoplasms MetaADEDB
Stomatitis ADReCS
Syncope ADReCS
Thrombocytopenia ADReCS
Thrombophlebitis ADReCS
Thrombosis MetaADEDB
Ulcer ADReCS
Uraemic Syndrome SIDER
Ureteral Obstruction MetaADEDB
Urinary Bladder Diseases MetaADEDB
Urinary Bladder Fistula MetaADEDB
Urinary Bladder Neoplasms MetaADEDB
Urination Disorders MetaADEDB
Vascular Diseases MetaADEDB
Vascular Neoplasms MetaADEDB
Vesicovaginal Fistula MetaADEDB
Vision Blurred ADReCS
Vision Disorders MetaADEDB
Vomiting ADReCS
Wounds And Injuries MetaADEDB

InAADR: Drug-Protein-ADRs database