InAADR: Drug-Protein-ADRs database

Drug Name:	Dihydralazine (484-23-1)
PubChem ID:	10230
SMILES:	C1=CC=C2C(=C1)C(=NN=C2NN)NN
InchiKey:	VQKLRVZQQYVIJW-UHFFFAOYSA-N
Therapeutic Category:	Antihypertensive Agents, Cardiovascular Agents

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug	Toxicity	Interaction Type	Mechanism	Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity	Interacting Protein	Mechanism	Reference
Hepatotoxicity	Cytochrome P450 1A2 (P05177)	The reactive metabolites produced are very short-lived and bind directly to the enzymes which generated them.A neoantigen is thus formed which triggers an immune response@characterized by the presence of autoantibodies in the patient#s serum.The autoantibodies are directed against the cytochrome P450 which generated the metabolite(s). [ ADR Type 2 ]	Immunotoxicology of the liver: adverse reactions to drugs

This panel provides drug-food interactions and their ADRs along with references

Food	Toxicity	Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite	Toxicity	Place of Metabolism	Mechanism	Reference

This panel provides information on drug category

Toxicity	Source
Cardiomyopathy Dilated	MetaADEDB
Drug Hypersensitivity	MetaADEDB
Drug-Induced Liver Injury	MetaADEDB
Heart Failure	MetaADEDB
Hepatitis	MetaADEDB
Hypertension	MetaADEDB
Hypotension	MetaADEDB
Ventricular Dysfunction Left	MetaADEDB

Molecular Weight (dalton)	:	190.21
LogP	:	0.201
Ring Count	:	2
Hydrogen Bond Acceptor Count	:	6
Hydrogen Bond Donor Count	:	4
Total Polar Surface Area	:	101.88