InAADR: Drug-Protein-ADRs database

Drug Name:	Tocainide (41708-72-9)
PubChem ID:	38945
SMILES:	CC1=C(C(=CC=C1)C)NC(=O)C(C)N
InchiKey:	BUJAGSGYPOAWEI-UHFFFAOYSA-N
Therapeutic Category:	Anti-Arrhythmia Agents, Cardiovascular Agents, Membrane Transport Modulators, Sodium Channel Blockers, Voltage-Gated Sodium Channel Blockers

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug	Toxicity	Interaction Type	Mechanism	Reference
Lidocaine (137-58-6)	Tonic-Clonic Seizure	Additive	Uncertain	Effect on the seizure threshold in dogs of tocainide/lidocaine administration

This panel provides drug-protein interaction and their ADRs along with references

Toxicity	Interacting Protein	Mechanism	Reference
Proarrhythmia	CYP2D6 (P10635)	Proarrhythmic and other toxic effects [ ADR Type 2 ]	Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW
Sudden Cardiac Death	Potassium voltage-gated channel subfamily E member 1 (P15382)	Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ]	Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death	Potassium voltage-gated channel subfamily H member 2 (Q12809)	Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ]	Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death	Potassium voltage-gated channel subfamily KQT member 1 (P51787)	Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ]	Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death	Sodium channel protein type 5 subunit alpha (Q14524)	Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ]	Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II

This panel provides drug-food interactions and their ADRs along with references

Food	Toxicity	Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite	Toxicity	Place of Metabolism	Mechanism	Reference

This panel provides information on drug category

Toxicity	Source
Agranulocytosis	MetaADEDB
Akathisia Drug-Induced	MetaADEDB
Anemia	MetaADEDB
Anemia Aplastic	MetaADEDB
Arrhythmias Cardiac	MetaADEDB
Bradycardia	MetaADEDB
Central Nervous System Diseases	MetaADEDB
Confusion	MetaADEDB
Connective Tissue Diseases	MetaADEDB
Dizziness	MetaADEDB
Dysarthria	MetaADEDB
Exanthema	MetaADEDB
Fever	MetaADEDB
Granuloma	MetaADEDB
Hallucinations	MetaADEDB
Headache	MetaADEDB
Heart Failure	MetaADEDB
Hepatitis	MetaADEDB
Leukopenia	MetaADEDB
Long Qt Syndrome	MetaADEDB
Myotonia Congenita	MetaADEDB
Nausea	MetaADEDB
Paranoid Disorders	MetaADEDB
Paresthesia	MetaADEDB
Pulmonary Fibrosis	MetaADEDB
Seizures	MetaADEDB
Sinoatrial Block	MetaADEDB
Skin Diseases	MetaADEDB
Tachycardia	MetaADEDB
Tachycardia Ventricular	MetaADEDB
Tinnitus	MetaADEDB
Ventricular Fibrillation	MetaADEDB
Ventricular Premature Complexes	MetaADEDB

Molecular Weight (dalton)	:	192.262
LogP	:	1.58914
Ring Count	:	1
Hydrogen Bond Acceptor Count	:	2
Hydrogen Bond Donor Count	:	2
Total Polar Surface Area	:	55.12