| Drug Name: | Ticrynafen (40180-04-9) |
|---|---|
| PubChem ID: | 38409 |
| SMILES: | C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl |
| InchiKey: | AGHANLSBXUWXTB-UHFFFAOYSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 331.176 |
| LogP | : | 3.7493 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 63.6 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Hepatotoxicity | Cytochrome P450 2C9 (P11712) | Tienilic acid-reactive metabolite(s) specifically bound to P450 2C9@ and experiments with yeast expressing active isolated P450s showed that P450 2C9 was responsible for tienilic acid-reactive metabolite(s) production Results of qualitative and quantitative covalent binding of tienilic acid metabolite(s) to human liver microsomes were then compared to those obtained with two drugs leading to direct toxic hepatitis@ namely@ acetaminophen and chloroform [ ADR Type 2 ] | Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Acute Kidney Injury | MetaADEDB |
| Hemorrhage | MetaADEDB |
| Hepatitis | MetaADEDB |
| Hypertension | MetaADEDB |
| Kidney Calculi | MetaADEDB |
| Nephritis Interstitial | MetaADEDB |