| Drug Name: | Triamterene (396-01-0) |
|---|---|
| PubChem ID: | 5546 |
| SMILES: | C1=CC=C(C=C1)C2=NC3=C(N=C2N)N=C(N=C3N)N |
| InchiKey: | FNYLWPVRPXGIIP-UHFFFAOYSA-N |
| Therapeutic Category: | Diuretics, Epithelial Sodium Channel Blockers, Membrane Transport Modulators, Natriuretic Agents, Sodium Channel Blockers |
| Molecular Weight (dalton) | : | 253.269 |
| LogP | : | 0.8334 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 7 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 129.62 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Methotrexate (59-05-2) | Mucosal Ulceration | Additive | Triamterene is structurally similar to folate and has anti-folate activity, which may therefore have been additive with the effects of methotrexate | Methotrexate and triamterene--a potentially fatal combination? |
| Methotrexate (59-05-2) | Pancytopenia | Additive | Triamterene is structurally similar to folate and has anti-folate activity, which may therefore have been additive with the effects of methotrexate | Methotrexate and triamterene--a potentially fatal combination? |
| Methotrexate (59-05-2) | Renal Impairment | Additive | Triamterene is structurally similar to folate and has anti-folate activity, which may therefore have been additive with the effects of methotrexate | Methotrexate and triamterene--a potentially fatal combination? |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category