| Drug Name: | Ribavirin (36791-04-5) |
|---|---|
| PubChem ID: | 37542 |
| SMILES: | C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N |
| InchiKey: | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
| Therapeutic Category: | Anti-Infective Agents, Antimetabolites, Antiviral Agents, Noxae |
| Molecular Weight (dalton) | : | 244.207 |
| LogP | : | -3.0115 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 8 |
| Hydrogen Bond Donor Count | : | 4 |
| Total Polar Surface Area | : | 143.72 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Affect Hepatic Functions | Albumin (P23110) | Ribavirin was found to inhibit both the synthesis and secretion of albumin in a time- and dose-dependent fashion Such an effect was confirmed by the measurement of albumin and haptoglobin secretion rates@which can directly affect hepatic functions in vitro [ ADR Type 1 ] | Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes |
| Affect Hepatic Functions | Epidermal growth factor receptor precursor (P00533) | [3H]-Thymidine incorporation was suppressed both in hepatocyte growth factor-stimulated human hepatocytes and in epidermal growth factor (EGF)-stimulated rat hepatocytes in the presence of ribavirin,demonstrating that ribavirin at concentrations close to those found in plasma of treated patients can directly affect hepatic functions in vitro [ ADR Type 1 ] | Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes |
| Affect Hepatic Functions | Haptoglobin (P00738) | Between 10 to 60 micromol/L, ribavirin was found to inhibit both the synthesis and secretion of haptoglobin in a time- and dose-dependent fashion,which can directly affect hepatic functions in vitro [ ADR Type 1 ] | Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes |
| Affect Hepatic Functions | Hepatocyte growth factor (P14210) | [3H]-Thymidine incorporation was suppressed both in hepatocyte growth factor-stimulated human hepatocytes and in epidermal growth factor (EGF)-stimulated rat hepatocytes in the presence of ribavirin@demonstrating that ribavirin at concentrations close to those found in plasma of treated patients can directly affect hepatic functions in vitro. [ ADR Type 1 ] | Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category