InAADR: Drug-Protein-ADRs database

Drug Name:	Fenbufen (36330-85-5)
PubChem ID:	3335
SMILES:	C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CCC(=O)O
InchiKey:	ZPAKPRAICRBAOD-UHFFFAOYSA-N
Therapeutic Category:

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug	Toxicity	Interaction Type	Mechanism	Reference
Enoxacin (74011-58-8)	Convulsions	Antagonistic	Not fully understood Experiments in mice have shown that quinolones competitively inhibit the binding of gamma-amino butyric acid (GABA) to its receptors Enoxacin and fenbufen are known to affect the GABA receptor site in the hippocampus and frontal cortex of mice, which is associated with convulsive activity the NSAID simply lowers the amount of quinolone needed to precipitate convulsions in already susceptible individuals	A case of convulsion, loss of consciousness and subsequent acute renal failure caused by enoxacin and fenbufen
Ofloxacin (82419-36-1)	Convulsions	Antagonistic	Not fully understood Experiments in mice have shown that quinolones competitively inhibit the binding of gamma-amino butyric acid (GABA) to its receptors the NSAID simply lowers the amount of quinolone needed to precipitate convulsions in already susceptible individuals	Effects of ketoprofen (NSAID) on the pharmacokinetics of pefloxacin and ofloxacin in healthy volunteers

This panel provides drug-protein interaction and their ADRs along with references

Toxicity	Interacting Protein	Mechanism	Reference

This panel provides drug-food interactions and their ADRs along with references

Food	Toxicity	Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite	Toxicity	Place of Metabolism	Mechanism	Reference

This panel provides information on drug category

Toxicity	Source

Molecular Weight (dalton)	:	254.285
LogP	:	3.4011
Ring Count	:	2
Hydrogen Bond Acceptor Count	:	2
Hydrogen Bond Donor Count	:	1
Total Polar Surface Area	:	54.37