| Drug Name: | Clomipramine (303-49-1) |
|---|---|
| PubChem ID: | 2801 |
| SMILES: | CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl |
| InchiKey: | GDLIGKIOYRNHDA-UHFFFAOYSA-N |
| Therapeutic Category: | Antidepressive Agents, Central Nervous System Agents, Membrane Transport Modulators, Neurotransmitter Agents, Neurotransmitter Uptake Inhibitors, Psychotropic Drugs, Serotonin Agents, Serotonin Uptake Inhibitors |
| Molecular Weight (dalton) | : | 314.86 |
| LogP | : | 4.5284 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 6.48 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Tramadol (27203-92-5) | Serotonin Syndrome | Antagonistic | Not Understood | Seizures reported with tramadol |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Antidepressant Response | Sodium-dependent serotonin transporter (P31645) | 5-Hydroxytryptamine neurotransmission@antidepressant response. [ ADR Type 1 ] | Serotonin transporter gene polymorphism and antidepressant response |
| Hepatitis | Cytochrome P450 2E1 (P05181) | Clomipramine increases oxidative and nitrosative stress@ which triggers of reoccurrence of amineptine-induced hepatitis [ ADR Type 4 ] | CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis |
| Toxicity And Inefficacy | CYP2D6 (P10635) | Toxicity in poor metabolisers@ inefficacy in ultrarapid metabolisers [ ADR Type 3 ] | Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category