| Drug Name: | Teniposide (29767-20-2) |
|---|---|
| PubChem ID: | 122172961 |
| SMILES: | COC1=CC(=CC(=C1O)OC)[C@@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@@H](O7)C8=CC=CS8)O)O |
| InchiKey: | NRUKOCRGYNPUPR-VEUOYOFCSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 656.662 |
| LogP | : | 2.7529 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 14 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 160.83 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Phenytoin (57-41-0) | Haematological Relapse And Cns Relapse | Antagonistic | antiepileptics are potent liver enzyme inducers, which may increase the metabolism of teniposide by the liver | Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Apoptosis | DNA topoisomerase 1 (P11387) | Rat thymocytes were treated in culture with prednisolone or the DNA topoisomerase I or II inhibitors@The appearance of apoptotic cells in cultures treated with pharmacological concentrations of these drugs@ observed as early as 3-6 hr after treatment@ coincided with the selective loss of G0 cells in these cultures. [ ADR Type 1 ] | Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases |
| Cytotoxicity | DNA topoisomerase 2-alpha (P11388) | Teniposide [4#-demethylepipophyllotoxin-4-(4@6-O-thenylidene-beta-D- glucopyranoside) (VM-26)] is a cancer chemotherapeutic drug with a high target specificity for DNA topoisomerase II@This agent INDUCES repairable protein-bridged double-strand DNA breaks@ which have been correlated with cytotoxicity@ but high concentrations of VM-26 also INDUCE irreversible DNA degradation and apoptotic cell death. [ ADR Type 3 ] | Teniposide induces nuclear but not mitochondrial DNA degradation |
| Dna Degradation | DNA topoisomerase 1 (P11387) | Different response of HL-60 cells to camptothecin@ teniposide@ or amsacrine via stabilization of the cleavable DNA-topoisomerase complexes through the pathway of rapidly triggered DNA degradation in S phase. [ ADR Type 3 ] | Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells |
| Elicit A Widespread Degradative Process Which Affects Nuclear Dna | Glucose-6-phosphate 1-dehydrogenase (P11413) | VM-26 can elicit a widespread degradative process which affects nuclear but not mitochondrial DNA.The inhibition of genes for 18S rRNA and glucose-6-phosphate dehydrogenase were representatives. [ ADR Type 1 ] | Teniposide induces nuclear but not mitochondrial DNA degradation |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category