| Drug Name: | Glipizide (29094-61-9) |
|---|---|
| PubChem ID: | 3478 |
| SMILES: | CC1=NC=C(N=C1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
| InchiKey: | ZJJXGWJIGJFDTL-UHFFFAOYSA-N |
| Therapeutic Category: | Hypoglycemic Agents |
| Molecular Weight (dalton) | : | 445.545 |
| LogP | : | 2.07812 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 130.15 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Hypoglycaemia | Cytochrome P450 2C9 (P11712) | Leu359 (CYP2C9) mutation is responsible for hypoglycaemia | |
| Suppression Of Hepatic Glucose Production | Glucose transporter-4 (P14672) | Glucose-induced suppression of hepatic glucose production was@ however@ more pronounced during GZ treatment ;GZ tends to normalize the activity of glycogen synthase and increases the content of GLUT 4 protein in skeletal muscle [ ADR Type 1 ] | Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity |
| Suppression Of Hepatic Glucose Production | Glycogen synthase (P13807) | Glucose-induced suppression of hepatic glucose production was@ however@ more pronounced during GZ treatment ;GZ tends to normalize the activity of glycogen synthase and increases the content of GLUT 4 protein in skeletal muscle. [ ADR Type 1 ] | Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category