InAADR

Drug Information

Drug Name: Vardenafil (224785-90-4)
PubChem ID: 10142962
SMILES: CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl
InchiKey: XCMULUAPJXCOHI-UHFFFAOYSA-N
Therapeutic Category: Cardiovascular Agents, Enzyme Inhibitors, Phosphodiesterase 5 Inhibitors, Phosphodiesterase Inhibitors, Urological Agents, Vasodilator Agents

Computed Drug Properties

Molecular Weight (dalton): 525.075
LogP: 2.49222
Ring Count: 3
Hydrogen Bond Acceptor Count: 8
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 112.9

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Vasodilatation Interactions between grapefruit juice and cardiovascular drugs

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abnormal Ecg MetaADEDB
Abnormal Ejaculation SIDER
Abnormal Sensation In Eye ADReCS
Accidental Injury ADReCS
Acquired Diaphragmatic Eventration MetaADEDB
Acromegaly MetaADEDB
Activities Of Daily Living Impaired MetaADEDB
Acute Coronary Syndrome ADReCS
Adjustment Disorder With Anxiety MetaADEDB
Adrenal Disorder MetaADEDB
Adverse Event MetaADEDB
Affective Disorder MetaADEDB
Agnosia MetaADEDB
Aion SIDER
Alanine Aminotransferase MetaADEDB
Alanine Aminotransferase Abnormal MetaADEDB
Alanine Aminotransferase Increased SIDER
Alcohol Poisoning MetaADEDB
Allergic Oedema ADReCS
Allergic Rhinitis MetaADEDB
Amaurosis Fugax MetaADEDB
Amblyopia MetaADEDB
Amimia MetaADEDB
Amnesia ADReCS
Anaphylactic Reaction ADReCS
Anaphylactic Shock ADReCS
Anastomotic Complication MetaADEDB
Aneurysm Ruptured MetaADEDB
Angina Pectoris ADReCS
Angina Unstable PROTECT
Angioedema ADReCS
Angioplasty MetaADEDB
Anorgasmia MetaADEDB
Anterior Ischemic Optic Neuropathy ADReCS
Antiphospholipid Syndrome MetaADEDB
Anxiety ADReCS
Aortic Aneurysm SIDER
Aortic Dissection SIDER
Arrhythmia ADReCS
Arterial Disorder ADReCS
Arterial Spasm MetaADEDB
Arteriosclerosis MetaADEDB
Arteriospasm Coronary MetaADEDB
Arthralgia ADReCS
Aspartate Aminotransferase MetaADEDB
Aspartate Aminotransferase Abnormal MetaADEDB
Aspartate Aminotransferase Increased SIDER
Aspermia MetaADEDB
Asthenia ADReCS
Atherosclerosis MetaADEDB
Atrial Ectopic Beats MetaADEDB
Atrial Tachycardia MetaADEDB
Atrioventricular Block Complete MetaADEDB
Atrioventricular Block First Degree MetaADEDB
Autonomic Neuropathy MetaADEDB
Azotaemia MetaADEDB
Back Pain ADReCS
Belching MetaADEDB
Bence Jones Protein Urine MetaADEDB
Black Stools MetaADEDB
Bladder Catheterisation MetaADEDB
Bleeding Gums MetaADEDB
Blindness ADReCS
Blindness Transient ADReCS
Blister Infected MetaADEDB
Blood Albumin MetaADEDB
Blood Albumin Abnormal MetaADEDB
Blood Alkaline Phosphatase MetaADEDB
Blood Bilirubin MetaADEDB
Blood Calcium MetaADEDB
Blood Creatine Phosphokinase Increased ADReCS
Blood Creatine Phosphokinase Mm Increased MetaADEDB
Blood Creatinine MetaADEDB
Blood Creatinine Increased ADReCS
Blood Follicle Stimulating Hormone Increased MetaADEDB
Blood Gases Abnormal MetaADEDB
Blood Luteinising Hormone Increased MetaADEDB
Blood Magnesium MetaADEDB
Blood Phosphorus MetaADEDB
Blood Potassium Increased MetaADEDB
Bone Cancer Metastatic MetaADEDB
Bone Disorder MetaADEDB
Bone Spur MetaADEDB
Bradycardia MetaADEDB
Brain Scan Abnormal MetaADEDB
Bronchitis MetaADEDB
Bruxism MetaADEDB
Burning Sensation ADReCS
Capillary Disorder MetaADEDB
Cardiac Death ADReCS
Cardiac Output Decreased MetaADEDB
Cardiac Valve Abscess MetaADEDB
Cardiomyopathy MetaADEDB
Cardiovascular Disorder ADReCS
Cerebral Haemorrhage PROTECT
Cerebral Sarcoidosis MetaADEDB
Cervical Root Pain MetaADEDB
Chest Pain ADReCS
Chill MetaADEDB
Chloropsia MetaADEDB
Cholecystitis Chronic MetaADEDB
Chorioretinal Disorder MetaADEDB
Chromatopsia ADReCS
Colitis Ischaemic MetaADEDB
Color Blindness MetaADEDB
Colour Blindness Acquired ADReCS
Congenital Cystic Kidney Disease MetaADEDB
Congenital Hypertrichosis MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Conjunctivitis ADReCS
Connective Tissue Inflammation MetaADEDB
Contact Dermatitis MetaADEDB
Convulsion ADReCS
Corneal Reflex Decreased MetaADEDB
Coronary Artery Disease ADReCS
Coronary Artery Restenosis MetaADEDB
Cramp Muscle SIDER
Creatine Phosphokinase Increased SIDER
Creatinine Increased SIDER
Creutzfeldt-Jakob Disease MetaADEDB
Cyanopsia ADReCS
Cytomegalovirus Oesophagitis MetaADEDB
Deafness ADReCS
Deafness Neurosensory MetaADEDB
Deafness Unilateral MetaADEDB
Death ADReCS
Debridement MetaADEDB
Decreased Interest MetaADEDB
Dehydroepiandrosterone Increased MetaADEDB
Demyelination MetaADEDB
Dental Operation MetaADEDB
Dermatitis ADReCS
Diabetes Insipidus MetaADEDB
Diabetes Mellitus ADReCS
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Acidosis MetaADEDB
Diabetic Autonomic Neuropathy MetaADEDB
Diarrhea Infectious MetaADEDB
Diarrhoea ADReCS
Discomfort ADReCS
Disinhibition MetaADEDB
Disorder Of Globe MetaADEDB
Diverticulitis Intestinal Haemorrhagic MetaADEDB
Dizziness ADReCS
Drug Effect Prolonged MetaADEDB
Drug Therapy Changed MetaADEDB
Drug Use For Unknown Indication MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Mouth ADReCS
Dry Skin MetaADEDB
Dry Throat MetaADEDB
Dysaesthesia ADReCS
Dyspepsia ADReCS
Dysphagia ADReCS
Dysphasia MetaADEDB
Dysphoria MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea ADReCS
Ear Infection MetaADEDB
Ear Neoplasm MetaADEDB
Ejaculation Delayed MetaADEDB
Ejaculation Disorder ADReCS
Ejaculation Failure MetaADEDB
Electrocardiogram St Segment Abnormal MetaADEDB
Electrocardiogram St Segment Depression MetaADEDB
Electrocardiogram T Wave Inversion MetaADEDB
Electromechanical Dissociation MetaADEDB
Elevated Prostate Specific Antigen MetaADEDB
Elevated Triglycerides MetaADEDB
Emotional Distress MetaADEDB
Endodontic Procedure MetaADEDB
Energy Increased MetaADEDB
Enuresis MetaADEDB
Epicondylitis MetaADEDB
Epididymitis MetaADEDB
Epistaxis ADReCS
Erectile Dysfunction MetaADEDB
Erection Increased ADReCS
Erythema ADReCS
Euphoric Mood MetaADEDB
Excessive Masturbation MetaADEDB
Excessive Salivation MetaADEDB
Exercise Tolerance Decreased MetaADEDB
Exfoliative Rash MetaADEDB
Extrasystoles MetaADEDB
Extrasystoles Ventricular MetaADEDB
Eye Haemorrhage ADReCS
Eye Infection Bacterial MetaADEDB
Eye Inflammation ADReCS
Eye Irritation ADReCS
Eye Pain ADReCS
Eye Redness SIDER
Face Oedema ADReCS
Facial Flushing MetaADEDB
Faecal Incontinence MetaADEDB
Faecal Occult Blood Positive MetaADEDB
Faeces Discoloured MetaADEDB
Fat Tissue Increased MetaADEDB
Feeling Abnormal ADReCS
Feeling Hot ADReCS
Feeling Of Body Temperature Change MetaADEDB
Femoral Artery Aneurysm MetaADEDB
Fistula Discharge MetaADEDB
Flashback MetaADEDB
Flashing Lights MetaADEDB
Flatulence MetaADEDB
Fluid Overload MetaADEDB
Flushing ADReCS
Foreign Body Sensation In Eyes MetaADEDB
Gall Bladder MetaADEDB
Gallbladder Perforation MetaADEDB
Gallbladder Polyp MetaADEDB
Gambling MetaADEDB
Gamma-Glutamyltransferase Increased ADReCS
Gangrene MetaADEDB
Gastric Ph Decreased MetaADEDB
Gastric Ulcer Haemorrhage MetaADEDB
Gastritis ADReCS
Gastroduodenal Ulcer MetaADEDB
Gastroduodenitis MetaADEDB
Gastrointestinal Disorder SIDER
Gastrointestinal Pain ADReCS
Gastrooesophageal Reflux Disease ADReCS
Genital Burning Sensation MetaADEDB
Genital Erythema MetaADEDB
Genital Pain MetaADEDB
Genital Pruritus Male MetaADEDB
Gingival Hyperplasia MetaADEDB
Gingival Pain MetaADEDB
Glare MetaADEDB
Glaucoma ADReCS
Global Amnesia SIDER
Granulocytosis MetaADEDB
Haematemesis ADReCS
Haematospermia PROTECT
Haematuria ADReCS
Haemoconcentration MetaADEDB
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemorrhage Intracranial MetaADEDB
Hangover MetaADEDB
Head Titubation MetaADEDB
Headache ADReCS
Hearing Impaired ADReCS
Heart Rate Increased MetaADEDB
Hemianopia MetaADEDB
Hepatic Congestion MetaADEDB
Hepatic Enzyme Increased ADReCS
Hepatic Function Abnormal ADReCS
Hepatic Vein Thrombosis MetaADEDB
Hiccough MetaADEDB
Hot Flush ADReCS
House Dust Allergy MetaADEDB
Hydrocele MetaADEDB
Hyperaemia ADReCS
Hypercoagulation MetaADEDB
Hyperhidrosis ADReCS
Hyperlipaemia MetaADEDB
Hyperlipidaemia ADReCS
Hypersensitivity ADReCS
Hypersexuality MetaADEDB
Hypertension ADReCS
Hypertonia ADReCS
Hypertrichosis MetaADEDB
Hypoacusis ADReCS
Hypoaesthesia ADReCS
Hypoaesthesia Facial MetaADEDB
Hypophagia MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Hypovolaemia MetaADEDB
Hypoxic Encephalopathy MetaADEDB
Ill-Defined Disorder ADReCS
Increased Upper Airway Secretion MetaADEDB
Infarction ADReCS
Infection Upper Respiratory MetaADEDB
Influenza ADReCS
Influenza Like Illness ADReCS
Infusion Site Haematoma MetaADEDB
Injury ADReCS
Insomnia ADReCS
International Normalised Ratio Increased MetaADEDB
Intestinal Operation MetaADEDB
Intestinal Polyp MetaADEDB
Intraocular Pressure Increased ADReCS
Iritis MetaADEDB
Ischaemia ADReCS
Ischaemic Cardiomyopathy MetaADEDB
Jaw Disorder MetaADEDB
Jaw Operation MetaADEDB
Joint Effusion MetaADEDB
Joint Stiffness MetaADEDB
Jra MetaADEDB
Keratitis Sicca MetaADEDB
Lacrimation SIDER
Lacrimation Increased ADReCS
Lacunar Infarction MetaADEDB
Laryngeal Oedema ADReCS
Left Atrial Dilatation MetaADEDB
Life Expectancy Shortened MetaADEDB
Liver Function Test Abnormal ADReCS
Loose Tooth MetaADEDB
Loss Of Consciousness ADReCS
Lower Respiratory Tract Infection Bacterial MetaADEDB
Lymphangitis MetaADEDB
Lymphocele MetaADEDB
Lymphocyte Count MetaADEDB
Malaise ADReCS
Mast Cell Disease MetaADEDB
Mastication Disorder MetaADEDB
Mastoiditis MetaADEDB
Mean Cell Haemoglobin Increased MetaADEDB
Mediastinal Disorder MetaADEDB
Mediastinal Tumor MetaADEDB
Meningitis Tuberculous MetaADEDB
Menopausal Symptoms ADReCS
Micturition Disorder MetaADEDB
Monoplegia MetaADEDB
Mountain Sickness Acute MetaADEDB
Multiple Injuries MetaADEDB
Muscle Rigidity ADReCS
Muscle Spasms ADReCS
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Myocardial Infarction ADReCS
Myocardial Ischaemia ADReCS
Nasal Congestion ADReCS
Nasal Discomfort MetaADEDB
Nasal Sinus Congestion MetaADEDB
Nausea ADReCS
Near Syncope MetaADEDB
Neck Pain ADReCS
Neovascularisation MetaADEDB
Neuralgia MetaADEDB
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Neutralising Antibodies MetaADEDB
Nicotine Dependence MetaADEDB
Night Blindness MetaADEDB
Nipple Pain MetaADEDB
No Adverse Drug Effect MetaADEDB
No Match PROTECT
No Therapeutic Response MetaADEDB
Nodule Skin MetaADEDB
Norepinephrine Increased MetaADEDB
Normochromic Normocytic Anaemia MetaADEDB
Obstruction MetaADEDB
Ocular Discomfort PROTECT
Ocular Hyperaemia ADReCS
Oedema ADReCS
Oedema Mucosal ADReCS
Oesophageal Discomfort MetaADEDB
Oesophageal Varices Haemorrhage MetaADEDB
Oesophagitis ADReCS
Optic Ischaemic Neuropathy ADReCS
Optic Nerve Disorder ADReCS
Orchitis MetaADEDB
Orgasm Abnormal MetaADEDB
Orthopnea MetaADEDB
Orthostatic Hypotension ADReCS
Osteomyelitis MetaADEDB
Pain ADReCS
Painful Erection MetaADEDB
Palpitation MetaADEDB
Palpitations ADReCS
Pancreatic Pseudocyst MetaADEDB
Pancreatitis MetaADEDB
Paraesthesia ADReCS
Partial Hearing Loss SIDER
Pedal Pulse Absent MetaADEDB
Penile Blister MetaADEDB
Penile Discharge MetaADEDB
Penile Haemorrhage PROTECT
Penile Pain MetaADEDB
Penis Deviation MetaADEDB
Peripheral Embolism MetaADEDB
Personality Change MetaADEDB
Pharyngeal Haemorrhage MetaADEDB
Pharyngitis ADReCS
Phlebitis MetaADEDB
Photodermatosis MetaADEDB
Photophobia ADReCS
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Platelet Disorder MetaADEDB
Pneumonia Staphylococcal MetaADEDB
Post Traumatic Stress Disorder MetaADEDB
Pre-Existing Condition Improved MetaADEDB
Premature Ejaculation SIDER
Priapism ADReCS
Primary Sequestrum MetaADEDB
Productive Cough MetaADEDB
Promotion Of Peripheral Circulation MetaADEDB
Prostate Cancer Metastatic MetaADEDB
Prostatitis MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus ADReCS
Pulmonary Haemorrhage ADReCS
Pulmonary Hypertension MetaADEDB
Pulse Pressure Decreased MetaADEDB
Purulence MetaADEDB
Radiation Exposure MetaADEDB
Rales MetaADEDB
Rash ADReCS
Red Blood Cells Semen MetaADEDB
Redness SIDER
Reflux Oesophagitis ADReCS
Renal Ischaemia MetaADEDB
Renal Tubular Necrosis MetaADEDB
Respiratory Rate Increased MetaADEDB
Retinal Artery Occlusion MetaADEDB
Retinal Infarction MetaADEDB
Retinal Migraine MetaADEDB
Retinal Neovascularisation MetaADEDB
Retinal Vascular Occlusion ADReCS
Retinal Vein Occlusion ADReCS
Rhinitis ADReCS
Rhinorrhea MetaADEDB
Scleral Pigmentation MetaADEDB
Scotoma ADReCS
Scrotal Haematoma MetaADEDB
Scrotal Irritation MetaADEDB
Scrotal Swelling MetaADEDB
Secondary Hypothyroidism MetaADEDB
Seizures SIDER
Semen Discolouration MetaADEDB
Semen Viscosity MetaADEDB
Semen Volume Increased MetaADEDB
Sensation Of Foreign Body MetaADEDB
Septic Phlebitis MetaADEDB
Shock ADReCS
Sick Sinus Syndrome MetaADEDB
Sickness SIDER
Sinus Congestion ADReCS
Sinus Headache ADReCS
Sinus Operation MetaADEDB
Sinus Pain SIDER
Sinusitis ADReCS
Sleep Disorder ADReCS
Soft Tissue Injuries MetaADEDB
Somnolence ADReCS
Spinal Osteoarthritis MetaADEDB
Spinning Sensation MetaADEDB
Splenic Infarction MetaADEDB
Spontaneous Penile Erection MetaADEDB
Starvation MetaADEDB
Sudden Cardiac Death ADReCS
Sudden Hearing Loss ADReCS
Sweating SIDER
Syncope ADReCS
Tachyarrhythmia ADReCS
Tachycardia ADReCS
Tachyphylaxis MetaADEDB
Telangiectases MetaADEDB
Tendon Rupture MetaADEDB
Testes Pain MetaADEDB
Testicular Mass MetaADEDB
Testicular Retraction MetaADEDB
Thalamic Infarction MetaADEDB
Tinnitus ADReCS
Tooth Extraction MetaADEDB
Tooth Infection MetaADEDB
Transaminases Increased ADReCS
Transient Global Amnesia ADReCS
Transient Ischaemic Attack PROTECT
Tricuspid Valve Disease MetaADEDB
Tunnel Vision MetaADEDB
Unevaluable Event MetaADEDB
Unexpected Therapeutic Drug Effect MetaADEDB
Urine Analysis Abnormal MetaADEDB
Urticaria Generalised MetaADEDB
Varicophlebitis MetaADEDB
Vascular Rupture MetaADEDB
Venous Occlusion ADReCS
Ventricular Arrhythmia ADReCS
Ventricular Tachyarrhythmia PROTECT
Ventricular Tachycardia ADReCS
Vertigo ADReCS
Violence-Related Symptom MetaADEDB
Vision Blurred ADReCS
Visual Acuity Reduced ADReCS
Visual Brightness MetaADEDB
Visual Disturbance ADReCS
Visual Field Defect ADReCS
Visual Impairment ADReCS
Vocal Cord Disorder MetaADEDB
Volume Blood Decreased MetaADEDB
Vomiting ADReCS
Wheeze MetaADEDB

InAADR: Drug-Protein-ADRs database