InAADR

Drug Information

Drug Name: Sitaxentan (210421-64-0)
PubChem ID:
SMILES: CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)NC4=C(C(=NO4)C)Cl)OCO2
InchiKey: PHWXUGHIIBDVKD-UHFFFAOYSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 454.913
LogP: 3.96124
Ring Count: 3
Hydrogen Bond Acceptor Count: 8
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 107.73

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort ADReCS
Abdominal Hernia MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Strangulated Hernia ADReCS
Abdominal Tenderness MetaADEDB
Abortion Spontaneous MetaADEDB
Abscess MetaADEDB
Acidosis MetaADEDB
Acrochordon MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Coronary Syndrome ADReCS
Acute Sinusitis MetaADEDB
Agitation MetaADEDB
Alanine Aminotransferase Increased MetaADEDB
Alopecia MetaADEDB
Alveolitis MetaADEDB
Alveolitis Allergic MetaADEDB
Amenorrhoea MetaADEDB
Anal Pruritus MetaADEDB
Anal Skin Tags MetaADEDB
Aneurysm MetaADEDB
Angina Pectoris MetaADEDB
Angiopathy MetaADEDB
Anorectal Discomfort ADReCS
Anorexia MetaADEDB
Aortic Aneurysm MetaADEDB
Appendicitis MetaADEDB
Arrhythmia ADReCS
Arteriovenous Fistula MetaADEDB
Arthritis ADReCS
Arthritis Bacterial MetaADEDB
Arthritis Infective MetaADEDB
Ascites MetaADEDB
Aspartate Aminotransferase Increased MetaADEDB
Aspiration MetaADEDB
Asthenia ADReCS
Asthma MetaADEDB
Ataxia MetaADEDB
Atrial Flutter MetaADEDB
Atrial Septal Defect MetaADEDB
Atrioventricular Block MetaADEDB
Atrioventricular Block First Degree MetaADEDB
Atrophy MetaADEDB
Basal Cell Carcinoma MetaADEDB
Bladder Disorder MetaADEDB
Blister MetaADEDB
Blood Bicarbonate Decreased MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Creatine Phosphokinase Increased ADReCS
Blood Creatinine Increased ADReCS
Blood Glucose Increased MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Decreased ADReCS
Blood Potassium Increased ADReCS
Blood Pressure Increased MetaADEDB
Blood Uric Acid Increased MetaADEDB
Body Temperature Increased MetaADEDB
Bradycardia MetaADEDB
Breast Calcifications ADReCS
Breast Disorder MetaADEDB
Breast Microcalcification MetaADEDB
Breast Pain MetaADEDB
Breast Tenderness MetaADEDB
Bronchitis MetaADEDB
Bronchitis MetaADEDB
Candidiasis MetaADEDB
Carcinoma MetaADEDB
Cardiac Disorder MetaADEDB
Cardiac Failure MetaADEDB
Cardiac Failure Congestive MetaADEDB
Cardiac Flutter MetaADEDB
Cardiac Murmur MetaADEDB
Cardiac Septal Defect MetaADEDB
Cellulitis MetaADEDB
Cerebrovascular Accident MetaADEDB
Cerumen Impaction MetaADEDB
Chest Discomfort MetaADEDB
Chest Pain MetaADEDB
Chest Wall Pain MetaADEDB
Cholecystitis MetaADEDB
Cholecystitis Chronic MetaADEDB
Cholelithiasis MetaADEDB
Cholestasis MetaADEDB
Coagulation Time Prolonged MetaADEDB
Colitis MetaADEDB
Colonic Polyp MetaADEDB
Confusional State MetaADEDB
Conjunctival Haemorrhage MetaADEDB
Conjunctival Hyperaemia MetaADEDB
Conjunctivitis MetaADEDB
Conjunctivitis Allergic MetaADEDB
Connective Tissue Inflammation MetaADEDB
Constipation MetaADEDB
Convulsion ADReCS
Cramp Muscle MetaADEDB
Creatine Phosphokinase Increased MetaADEDB
Creatinine Increased MetaADEDB
Cyst MetaADEDB
Deafness MetaADEDB
Decreased Appetite MetaADEDB
Dehydration MetaADEDB
Dermatitis MetaADEDB
Dermatitis Atopic MetaADEDB
Dermatitis Bullous ADReCS
Dermatitis Contact MetaADEDB
Dilatation Atrial MetaADEDB
Discomfort MetaADEDB
Disturbance In Attention MetaADEDB
Diverticulum MetaADEDB
Dizziness MetaADEDB
Dizziness Postural MetaADEDB
Drug Hypersensitivity MetaADEDB
Dry Mouth MetaADEDB
Dry Skin MetaADEDB
Dry Throat MetaADEDB
Dysaesthesia MetaADEDB
Dyspepsia MetaADEDB
Dysphonia MetaADEDB
Dyspnoea MetaADEDB
Dyspnoea Exertional MetaADEDB
Dyspnoea Paroxysmal Nocturnal MetaADEDB
Dysuria MetaADEDB
Ear Congestion MetaADEDB
Ear Discomfort ADReCS
Ear Feels Clogged MetaADEDB
Ear Infection ADReCS
Ear Pain MetaADEDB
Effusion MetaADEDB
Electrocardiogram Qt Prolonged MetaADEDB
Embolism MetaADEDB
Endocrine Disorder MetaADEDB
Enteritis MetaADEDB
Eosinophilia MetaADEDB
Epistaxis MetaADEDB
Eructation MetaADEDB
Erythema MetaADEDB
Extrasystoles MetaADEDB
Eye Disorder MetaADEDB
Eye Infection MetaADEDB
Eye Inflammation MetaADEDB
Eye Irritation MetaADEDB
Eye Oedema MetaADEDB
Eye Pruritus MetaADEDB
Eyelid Ptosis ADReCS
Facial Pain MetaADEDB
Facial Paralysis MetaADEDB
Faecal Incontinence MetaADEDB
Fatigue MetaADEDB
Feeling Abnormal ADReCS
Feeling Cold ADReCS
Feeling Cool MetaADEDB
Feeling Hot MetaADEDB
Fibromyalgia MetaADEDB
Fistula MetaADEDB
Flank Pain MetaADEDB
Fluid Retention MetaADEDB
Flushing MetaADEDB
Frequent Bowel Movements MetaADEDB
Fungal Infection MetaADEDB
Furuncle MetaADEDB
Gallbladder Disorder MetaADEDB
Gastritis MetaADEDB
Gastritis Viral MetaADEDB
Gastroenteritis MetaADEDB
Gastroenteritis Bacterial MetaADEDB
Gastrointestinal Discomfort MetaADEDB
Gastrointestinal Disorder MetaADEDB
Gastrointestinal Haemorrhage MetaADEDB
Gastrointestinal Infection MetaADEDB
Gastrointestinal Pain ADReCS
Genital Itching Female MetaADEDB
Gingival Pain MetaADEDB
Gingivitis MetaADEDB
Glossodynia MetaADEDB
Glucose Increased MetaADEDB
Goitre MetaADEDB
Gout MetaADEDB
Gouty Tophus MetaADEDB
Groin Pain MetaADEDB
Haematochezia MetaADEDB
Haematocrit Decreased MetaADEDB
Haematocrit Increased MetaADEDB
Haematoma MetaADEDB
Haematuria MetaADEDB
Haemoglobin ADReCS
Haemoglobin Decreased MetaADEDB
Haemoglobin Increased MetaADEDB
Haemorrhage MetaADEDB
Haemorrhoids MetaADEDB
Head Discomfort MetaADEDB
Headache MetaADEDB
Heart Rate Irregular MetaADEDB
Hepatic Enzyme Increased MetaADEDB
Hepatic Failure MetaADEDB
Hepatitis MetaADEDB
Hepatobiliary Disease MetaADEDB
Hepatomegaly MetaADEDB
Hernia MetaADEDB
Herpes Nos MetaADEDB
Herpes Simplex MetaADEDB
Herpes Virus Infection ADReCS
Herpes Zoster MetaADEDB
Hiccups MetaADEDB
Hoarseness MetaADEDB
Hyperaemia MetaADEDB
Hyperaesthesia ADReCS
Hyperbilirubinaemia MetaADEDB
Hypercholesterolaemia MetaADEDB
Hyperglycaemia MetaADEDB
Hyperhidrosis ADReCS
Hyperkalaemia MetaADEDB
Hypernatraemia MetaADEDB
Hypersensitivity MetaADEDB
Hyperthermia MetaADEDB
Hypertrophy MetaADEDB
Hypocalcaemia MetaADEDB
Hypoglycaemia MetaADEDB
Hypotension MetaADEDB
Hypoxia MetaADEDB
Ill-Defined Disorder ADReCS
Immune System Disorder MetaADEDB
Incontinence MetaADEDB
Increased Appetite MetaADEDB
Infarction MetaADEDB
Infection MetaADEDB
Infestation Nos MetaADEDB
Inflammation MetaADEDB
Inflammation Localised MetaADEDB
Insomnia MetaADEDB
Insufficiency Renal MetaADEDB
International Normalised Ratio Increased MetaADEDB
Intertrigo MetaADEDB
Ischaemic Stroke MetaADEDB
Jaundice MetaADEDB
Joint Stiffness MetaADEDB
Keratitis ADReCS
Keratoconjunctivitis MetaADEDB
Keratoconjunctivitis Sicca MetaADEDB
Lacrimation MetaADEDB
Lacrimation Increased MetaADEDB
Lactic Acidosis MetaADEDB
Lactic Dehydrogenase Activity Increased MetaADEDB
Leiomyoma MetaADEDB
Leukopenia MetaADEDB
Liver Function Test Abnormal MetaADEDB
Lobar Pneumonia MetaADEDB
Localised Infection MetaADEDB
Localised Oedema MetaADEDB
Lower Respiratory Tract Infection MetaADEDB
Lung Infection MetaADEDB
Lupus Erythematosus MetaADEDB
Lymphoma MetaADEDB
Malaise MetaADEDB
Mediastinal Disorder MetaADEDB
Memory Impairment MetaADEDB
Menopausal Symptoms MetaADEDB
Menopause MetaADEDB
Menorrhagia MetaADEDB
Mental Disability ADReCS
Mental Disorder MetaADEDB
Metrorrhagia MetaADEDB
Migraine MetaADEDB
Mouth Haemorrhage MetaADEDB
Muscle Atrophy MetaADEDB
Muscle Fatigue MetaADEDB
Muscle Haemorrhage MetaADEDB
Muscle Spasms MetaADEDB
Muscle Twitching MetaADEDB
Muscular Weakness MetaADEDB
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Pain MetaADEDB
Musculoskeletal Stiffness ADReCS
Myeloproliferative Disorder MetaADEDB
Myocardial Infarction MetaADEDB
Nail Hypertrophy MetaADEDB
Nasal Congestion MetaADEDB
Nasal Sinus Drainage MetaADEDB
Nausea MetaADEDB
Necrosis MetaADEDB
Neoplasm MetaADEDB
Neoplasm Malignant ADReCS
Nephritis MetaADEDB
Nephritis Interstitial MetaADEDB
Nervous System Disorder MetaADEDB
Nervousness MetaADEDB
Night Sweats MetaADEDB
Nipple Pain MetaADEDB
Nocturnal Dyspnoea MetaADEDB
Oedema MetaADEDB
Oedema Peripheral MetaADEDB
Oesophageal Spasm MetaADEDB
Onychomycosis MetaADEDB
Oral Candidiasis MetaADEDB
Oral Pruritus MetaADEDB
Organ Failure MetaADEDB
Orthopnoea MetaADEDB
Orthostatic Hypotension MetaADEDB
Osteoarthritis MetaADEDB
Osteochondrosis MetaADEDB
Otitis MetaADEDB
Otitis Media MetaADEDB
Ovarian Cyst MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain MetaADEDB
Pain In Jaw MetaADEDB
Pallor MetaADEDB
Palmar Erythema MetaADEDB
Pancreatic Pseudocyst MetaADEDB
Pancreatitis MetaADEDB
Pancreatitis Acute MetaADEDB
Pancytopenia MetaADEDB
Papilloma MetaADEDB
Paraesthesia MetaADEDB
Paraesthesia Oral MetaADEDB
Paralysis MetaADEDB
Paronychia MetaADEDB
Partial Seizures MetaADEDB
Peptic Ulcer MetaADEDB
Pericardial Effusion MetaADEDB
Petechiae MetaADEDB
Photophobia MetaADEDB
Pleural Disorder MetaADEDB
Pleural Effusion MetaADEDB
Pleurisy MetaADEDB
Pleuritic Pain MetaADEDB
Pneumonia ADReCS
Pneumonia Aspiration MetaADEDB
Pneumothorax MetaADEDB
Pollakiuria MetaADEDB
Polyarthritis MetaADEDB
Polydipsia MetaADEDB
Polyp MetaADEDB
Post Thrombotic Syndrome MetaADEDB
Potassium Increased MetaADEDB
Potassium Low MetaADEDB
Pregnancy Test Positive MetaADEDB
Primary Pulmonary Hypertension MetaADEDB
Proctalgia MetaADEDB
Protein Urine Present ADReCS
Proteinuria MetaADEDB
Prothrombin Level Increased MetaADEDB
Pruritus MetaADEDB
Pruritus Generalised MetaADEDB
Pruritus Genital MetaADEDB
Pseudocyst MetaADEDB
Psoriasis MetaADEDB
Ptosis MetaADEDB
Ptt Prolonged MetaADEDB
Pulmonary Arterial Hypertension ADReCS
Pulmonary Embolism MetaADEDB
Raised Liver Function Tests MetaADEDB
Rash MetaADEDB
Rash Macular MetaADEDB
Rash Papular MetaADEDB
Rash Pustular MetaADEDB
Red Blood Cell Count Decreased MetaADEDB
Renal Failure ADReCS
Renal Impairment MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Tract Infection MetaADEDB
Restless Legs Syndrome MetaADEDB
Retching MetaADEDB
Retinal Detachment MetaADEDB
Retinal Disorder MetaADEDB
Retinal Tear MetaADEDB
Rhinitis MetaADEDB
Right Ventricular Failure MetaADEDB
Rosacea MetaADEDB
Sciatica MetaADEDB
Seizures MetaADEDB
Sensation Of Foreign Body MetaADEDB
Sicca Syndrome MetaADEDB
Sinus Bradycardia MetaADEDB
Sinus Congestion MetaADEDB
Sinus Headache MetaADEDB
Sinus Operation ADReCS
Sinus Pain MetaADEDB
Sinusitis MetaADEDB
Skin Disorder MetaADEDB
Skin Exfoliation MetaADEDB
Skin Hyperpigmentation MetaADEDB
Skin Irritation MetaADEDB
Skin Lesion MetaADEDB
Skin Necrosis MetaADEDB
Skin Papilloma MetaADEDB
Skin Ulcer MetaADEDB
Sleep Disorder MetaADEDB
Sneezing MetaADEDB
Somnolence MetaADEDB
Sputum Purulent MetaADEDB
Stiffness MetaADEDB
Stomatitis MetaADEDB
Strangulated Hernia MetaADEDB
Subcutaneous Abscess MetaADEDB
Supraventricular Extrasystoles MetaADEDB
Supraventricular Tachycardia MetaADEDB
Sweating MetaADEDB
Systemic Lupus Erythematosus MetaADEDB
Tachycardia MetaADEDB
Tachypnoea MetaADEDB
Tenderness MetaADEDB
Tendonitis MetaADEDB
Tension ADReCS
Testicular Pain MetaADEDB
Thinking Abnormal MetaADEDB
Throat Irritation MetaADEDB
Thrombocytopenia MetaADEDB
Thrombophlebitis MetaADEDB
Thrombophlebitis Superficial MetaADEDB
Tinnitus MetaADEDB
Tongue Blistering MetaADEDB
Tongue Discolouration MetaADEDB
Tongue Disorder MetaADEDB
Tongue Ulceration MetaADEDB
Tooth Abscess MetaADEDB
Tooth Impacted MetaADEDB
Tracheobronchitis ADReCS
Tremor MetaADEDB
Tubulointerstitial Nephritis ADReCS
Ulcer MetaADEDB
Urinary Tract Disorder MetaADEDB
Urosepsis MetaADEDB
Urticaria MetaADEDB
Uterine Leiomyoma MetaADEDB
Uterovaginal Prolapse ADReCS
Vaginal Haemorrhage MetaADEDB
Vaginal Infection MetaADEDB
Vaginal Prolapse MetaADEDB
Venous Insufficiency ADReCS
Venous Pressure Jugular MetaADEDB
Venous Pressure Jugular Increased MetaADEDB
Venous Thrombosis MetaADEDB
Ventricular Bigeminy MetaADEDB
Ventricular Extrasystoles MetaADEDB
Ventricular Failure MetaADEDB
Ventricular Tachycardia MetaADEDB
Vertigo MetaADEDB
Viith Nerve Paralysis ADReCS
Viral Diarrhoea MetaADEDB
Viral Infection MetaADEDB
Visual Disturbance MetaADEDB
Visual Impairment ADReCS
Vitreous Floaters MetaADEDB
Vomiting MetaADEDB
Weakness MetaADEDB
Weight Decreased MetaADEDB
Weight Fluctuation MetaADEDB
Wheezing MetaADEDB
White Blood Cell Count Decreased MetaADEDB

InAADR: Drug-Protein-ADRs database