InAADR

Drug Information

Drug Name: Darbepoetin alfa (209810-58-2)
PubChem ID: 124040763
SMILES: CCC1CN2CC[C@@H]1CC2C(C3=C4C=C(C=CC4=NC=C3)OC)OC5=NN=C(C6=CC=CC=C65)OC(C7C[C@H]8CCN7CC8CC)C9=C1C=C(C=CC1=NC=C9)OC
InchiKey: YUCBLVFHJWOYDN-FYEDOUJPSA-N
Therapeutic Category: Hematinics, Hematologic Agents

Computed Drug Properties

Molecular Weight (dalton): 778.998
LogP: 9.2244
Ring Count: 6
Hydrogen Bond Acceptor Count: 10
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 94.96

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Thalidomide (50-35-1) Thromboembolic Event Synergistic Not understood Thromboembolic events in patients with myelodysplastic syndrome receiving thalidomide in combination with darbepoietin-alpha

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Acute Myocardial Infarction ADReCS
Anaphylactic Reaction PROTECT
Angina Pectoris ADReCS
Angioedema PROTECT
Aplasia Pure Red Cell PROTECT
Arrhythmia ADReCS
Arthralgia ADReCS
Asthenia ADReCS
Back Pain ADReCS
Bone Pain ADReCS
Bronchitis ADReCS
Bronchospasm PROTECT
Cardiac Failure Congestive ADReCS
Catheter Sepsis ADReCS
Cerebrovascular Accident PROTECT
Chest Pain ADReCS
Chills ADReCS
Constipation ADReCS
Convulsion ADReCS
Cough ADReCS
Death ADReCS
Deep Vein Thrombosis ADReCS
Dehydration ADReCS
Depression ADReCS
Device Related Infection ADReCS
Diarrhoea ADReCS
Dizziness ADReCS
Dysphagia ADReCS
Dyspnoea ADReCS
Embolism Arterial PROTECT
Erythema ADReCS
Fatigue ADReCS
Fluid Overload ADReCS
Haemorrhage ADReCS
Headache ADReCS
Hyperglycaemia ADReCS
Hypersensitivity ADReCS
Hypertension ADReCS
Hypokalaemia ADReCS
Hypotension ADReCS
Infection ADReCS
Influenza Like Illness ADReCS
Injection Site Irritation ADReCS
Injection Site Pain ADReCS
Injection Site Reaction ADReCS
Insomnia ADReCS
Leukopenia ADReCS
Medical Device Complication ADReCS
Muscle Spasms ADReCS
Myalgia ADReCS
Myocardial Infarction ADReCS
Nasopharyngitis ADReCS
Nausea ADReCS
Oedema ADReCS
Oedema Peripheral ADReCS
Pain In Extremity ADReCS
Peritonitis ADReCS
Porphyria ADReCS
Pruritus ADReCS
Pulmonary Embolism ADReCS
Pyrexia ADReCS
Rash ADReCS
Renal Failure Chronic ADReCS
Respiratory Tract Congestion ADReCS
Stomatitis ADReCS
Stroke ADReCS
Thrombosis ADReCS
Transient Ischaemic Attack ADReCS
Upper Respiratory Tract Infection ADReCS
Urticaria ADReCS
Vascular Access Complication ADReCS
Vascular Occlusion ADReCS
Venous Thrombosis ADReCS
Vomiting ADReCS
Weight Decreased ADReCS

InAADR: Drug-Protein-ADRs database