InAADR

Drug Information

Drug Name: Propofol (2078-54-8)
PubChem ID: 4943
SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)O
InchiKey: OLBCVFGFOZPWHH-UHFFFAOYSA-N
Therapeutic Category: Anesthetics, Central Nervous System Agents, Central Nervous System Depressants, Hypnotics and Sedatives

Computed Drug Properties

Molecular Weight (dalton): 178.275
LogP: 3.639
Ring Count: 1
Hydrogen Bond Acceptor Count: 1
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 20.23

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Cocaine (50-36-2) Convulsions Antagonistic Not Understood Convulsions after cocaine and propofol

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Cramp MetaADEDB
Abnormal Dreams ADReCS
Abulia MetaADEDB
Accelerated Idioventricular Rhythm MetaADEDB
Accident MetaADEDB
Acidosis ADReCS
Acidosis Lactic MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Coronary Syndrome ADReCS
Acute Kidney Injury MetaADEDB
Acute Pulmonary Oedema MetaADEDB
Acute Respiratory Distress Syndrome MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenoid Hypertrophy MetaADEDB
Adverse Event MetaADEDB
Affect Lability ADReCS
Afib MetaADEDB
Aggression ADReCS
Agitation ADReCS
Agitation Postoperative MetaADEDB
Agranulocytoses MetaADEDB
Agraphia MetaADEDB
Airway Complication Of Anaesthesia ADReCS
Airway Obstruction MetaADEDB
Airway Obstruction Nos SIDER
Akathisia Drug-Induced MetaADEDB
Allergic Dermatitis MetaADEDB
Altered State Of Consciousness ADReCS
Alveolitis MetaADEDB
Amblyopia ADReCS
Amentia MetaADEDB
Ammonia Increased MetaADEDB
Amnesia MetaADEDB
Amnesia Anterograde MetaADEDB
Amnesia Retrograde MetaADEDB
Anaemia MetaADEDB
Anaemia Postoperative MetaADEDB
Anaesthetic Complication MetaADEDB
Anaphylactic Reaction ADReCS
Anaphylactic Shock ADReCS
Anaphylactoid Reaction ADReCS
Anaphylaxis MetaADEDB
Angioedema ADReCS
Anguish SIDER
Anisocoria MetaADEDB
Anoxia MetaADEDB
Anticholinergic Syndrome ADReCS
Antithrombin Iii Decreased MetaADEDB
Anuria MetaADEDB
Anxiety ADReCS
Apnea MetaADEDB
Apnoea ADReCS
Apparent Life Threatening Event MetaADEDB
Arrhythmia ADReCS
Arrhythmia Sinus MetaADEDB
Arrhythmia Supraventricular ADReCS
Arrhythmias Cardiac MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Aspartate Aminotransferase Abnormal MetaADEDB
Asthenia ADReCS
Asthmatic Crisis MetaADEDB
Ataxia MetaADEDB
Atelectasis MetaADEDB
Atrial Arrhythmia SIDER
Atrial Fibrillation ADReCS
Atrial Tachycardia MetaADEDB
Atrioventricular Block ADReCS
Bacteria Urine MetaADEDB
Bacterial Pneumonia MetaADEDB
Bacterial Sepsis MetaADEDB
Bacterial Test Positive MetaADEDB
Bacterial Toxaemia MetaADEDB
Basal Ganglia Diseases MetaADEDB
Bile Duct Obstruction MetaADEDB
Bladder Spasm MetaADEDB
Blindness ADReCS
Block Heart SIDER
Blood Beta-D-Glucan Increased MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Brain Barrier Defect MetaADEDB
Blood Cholinesterase MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Creatinine MetaADEDB
Blood Creatinine Increased ADReCS
Blood In Urine MetaADEDB
Blood Osmolarity Increased ADReCS
Blood Potassium Increased MetaADEDB
Blood Urea Increased ADReCS
Blood Uric Acid MetaADEDB
Body Temperature MetaADEDB
Body Temperature Increased ADReCS
Bradycardia ADReCS
Brain Damage MetaADEDB
Brain Death MetaADEDB
Brain Edema MetaADEDB
Brain Injuries MetaADEDB
Brain Ischemia MetaADEDB
Brain Stem Infarction MetaADEDB
Breath Sounds Abnormal MetaADEDB
Bronchial Spasm MetaADEDB
Bronchospasm ADReCS
Brugada Syndrome MetaADEDB
Bundle Branch Block ADReCS
Caecitis MetaADEDB
Carcinoid Syndrome MetaADEDB
Cardiac Arrest ADReCS
Cardiac Decompensation MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Acute MetaADEDB
Cardiac Failure Right SIDER
Cardiac Fibrillation ADReCS
Cardiac Output Decreased ADReCS
Cardiac Output Low MetaADEDB
Cardiac Procedure Complication MetaADEDB
Cardiac Septal Defect MetaADEDB
Cardiac Valve Disease MetaADEDB
Cardiac Ventricular Disorder ADReCS
Cardio-Respiratory Arrest MetaADEDB
Cardio-Respiratory Distress MetaADEDB
Cardiogenic Shock MetaADEDB
Cardiomyopathies MetaADEDB
Cardiovascular Diseases MetaADEDB
Cardiovascular Disorder MetaADEDB
Catheter Related Complication MetaADEDB
Cauda Equina Syndrome MetaADEDB
Cellulitis MetaADEDB
Central Nervous System Diseases MetaADEDB
Cerebral Disorder MetaADEDB
Chest Pain ADReCS
Chills ADReCS
Cholangiolitis MetaADEDB
Chorea MetaADEDB
Chronobiology Disorders MetaADEDB
Clostridial Infection MetaADEDB
Clotting MetaADEDB
Cloudy Urine SIDER
Coagulation Factor Viii Level Decreased MetaADEDB
Coagulopathy ADReCS
Cognition Disorders MetaADEDB
Coma MetaADEDB
Communication Disorder MetaADEDB
Confusion MetaADEDB
Confusional State ADReCS
Conjunctival Hyperaemia ADReCS
Continuous Haemodiafiltration MetaADEDB
Conversion Disorder ADReCS
Convulsion ADReCS
Cough ADReCS
Coughing Blood MetaADEDB
Cramp Muscle SIDER
Creatinine Increased SIDER
Cutaneous Ulcer MetaADEDB
Cyanosis MetaADEDB
Cystostomy MetaADEDB
Death ADReCS
Death Sudden Cardiac MetaADEDB
Dehydration ADReCS
Delayed Emergence From Anesthesia MetaADEDB
Delayed Recovery From Anaesthesia MetaADEDB
Delirium ADReCS
Dependence MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Dermatitis Bullous MetaADEDB
Device Failure MetaADEDB
Diabetes Insipidus MetaADEDB
Dialysis MetaADEDB
Diarrhoea ADReCS
Diastolic Dysfunction MetaADEDB
Diplopia ADReCS
Disease Of Liver MetaADEDB
Disinhibition MetaADEDB
Disorder Lung MetaADEDB
Disorder Renal MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Dizziness ADReCS
Drug Abuse ADReCS
Drug Abuser MetaADEDB
Drug Effect Increased ADReCS
Drug Hypersensitivity MetaADEDB
Drug Interaction MetaADEDB
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Mouth ADReCS
Dysgeusia ADReCS
Dyskinesia Drug-Induced MetaADEDB
Dyspepsia MetaADEDB
Dysphagia ADReCS
Dyspnoea ADReCS
Dystonia ADReCS
Dystonic Disorders MetaADEDB
Ear Pain ADReCS
Edema MetaADEDB
Electrocardiogram Abnormal ADReCS
Electrocardiogram St Segment SIDER
Electrocardiogram St Segment Depression ADReCS
Electromechanical Dissociation MetaADEDB
Electromyogram Abnormal MetaADEDB
Embolism MetaADEDB
Embolism Fat MetaADEDB
Embolism Pulmonary MetaADEDB
Emotional Disorder ADReCS
Encephalopathy MetaADEDB
Endocarditis MetaADEDB
Enlarged Spleen MetaADEDB
Enterococcal Bacteraemia MetaADEDB
Epidermolysis MetaADEDB
Epilepsy MetaADEDB
Epilepsy Generalized MetaADEDB
Epilepsy Tonic-Clonic MetaADEDB
Erythema ADReCS
Escherichia Infection MetaADEDB
Euphoric Mood ADReCS
Exanthema MetaADEDB
Excess Potassium MetaADEDB
Extrasystoles ADReCS
Extrasystoles Ventricular MetaADEDB
Extravasation Of Diagnostic And Therapeutic Materials MetaADEDB
Eye Pain ADReCS
Fasciculation MetaADEDB
Fatigue ADReCS
Fatty Liver MetaADEDB
Feeling Abnormal ADReCS
Fever MetaADEDB
Fibrin D Dimer MetaADEDB
Flushing ADReCS
Foreign Body Trauma MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gastroenteritis MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Stenosis MetaADEDB
Glycosuria MetaADEDB
Gout MetaADEDB
Gouty Tophus MetaADEDB
Granulocytosis MetaADEDB
Grip Strength MetaADEDB
Haematoma MetaADEDB
Haemodialysis MetaADEDB
Haemodynamic Instability MetaADEDB
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemorrhagic Cerebral Infarction MetaADEDB
Hallucination ADReCS
Hallucinations MetaADEDB
Headache ADReCS
Heart Arrest MetaADEDB
Heart Block MetaADEDB
Heart Diseases MetaADEDB
Heart Failure MetaADEDB
Heart Rate Increased MetaADEDB
Hematoma Subdural MetaADEDB
Heparin-Induced Thrombocytopenia MetaADEDB
Hepatic Congestion MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Function Abnormal ADReCS
Hepatic Haematoma MetaADEDB
Hepatic Necrosis MetaADEDB
Hepatic Trauma MetaADEDB
Hepatitis Fulminant MetaADEDB
Hepatocellular Damage MetaADEDB
Hepatomegaly MetaADEDB
Hepatotoxicity MetaADEDB
Hiccup MetaADEDB
Hiccups ADReCS
Hydrocephalus MetaADEDB
Hyperaemia ADReCS
Hyperalgesia MetaADEDB
Hyperammonaemia MetaADEDB
Hyperemia MetaADEDB
Hyperglycaemia ADReCS
Hyperhidrosis ADReCS
Hyperkalaemia ADReCS
Hyperkalemia MetaADEDB
Hyperlipidaemia ADReCS
Hyperlipidemias MetaADEDB
Hypertension ADReCS
Hypertension Pulmonary MetaADEDB
Hypertonia ADReCS
Hypertransaminasaemia MetaADEDB
Hypertriglyceridemia MetaADEDB
Hyperventilation ADReCS
Hypoalbuminaemia MetaADEDB
Hypokalaemia MetaADEDB
Hypomagnesaemia ADReCS
Hypotension ADReCS
Hypothermia MetaADEDB
Hypotonia ADReCS
Hypoventilation ADReCS
Hypoxia ADReCS
Hysteria ADReCS
Iatrogenic Injury MetaADEDB
Ild MetaADEDB
Ileus ADReCS
Illusion MetaADEDB
Increased White Blood Cell Count MetaADEDB
Infarction ADReCS
Inflammation MetaADEDB
Insomnia ADReCS
Intestinal Infarction MetaADEDB
Intracranial Pressure Increased ADReCS
Intraoperative Complications MetaADEDB
Intubation MetaADEDB
Ischaemia ADReCS
Ischaemic Stroke MetaADEDB
Kidney Diseases MetaADEDB
Large Intestine Perforation MetaADEDB
Laryngospasm ADReCS
Learning Disorders MetaADEDB
Leukocytosis ADReCS
Leukoencephalopathies MetaADEDB
Lipids Increased MetaADEDB
Liver Diseases MetaADEDB
Liver Failure MetaADEDB
Loss Of Consciousness ADReCS
Lung Neoplasm Malignant MetaADEDB
Lyell MetaADEDB
Malabsorption MetaADEDB
Mechanical Ventilation MetaADEDB
Medical Device Complication MetaADEDB
Memory Disorders MetaADEDB
Meningism MetaADEDB
Mental Disability ADReCS
Mental Status Changes MetaADEDB
Metabolic Acidosis ADReCS
Metabolic Encephalopathy MetaADEDB
Methaemoglobinaemia MetaADEDB
Microcephaly MetaADEDB
Micturition Disorder MetaADEDB
Mitochondrial Myopathy Acquired MetaADEDB
Mixed Hepatocellular-Cholestatic Injury MetaADEDB
Moaning ADReCS
Monocytosis MetaADEDB
Monoplegia MetaADEDB
Mood Disorder Due To A General Medical Condition MetaADEDB
Mood Swings ADReCS
Movement Disorder ADReCS
Movement Disorders MetaADEDB
Multi-Organ Disorder MetaADEDB
Multi-Organ Failure MetaADEDB
Multiple Organ Failure MetaADEDB
Muscle Hypertonia MetaADEDB
Muscle Necrosis MetaADEDB
Muscle Relaxant Therapy ADReCS
Muscle Rigidity ADReCS
Muscle Spasms ADReCS
Muscle Twitching ADReCS
Muscle Weakness MetaADEDB
Muscular Diseases MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Stiffness ADReCS
Mutism MetaADEDB
Myalgia ADReCS
Myocardial Infarction ADReCS
Myocardial Ischaemia ADReCS
Myocardial Ischemia MetaADEDB
Myoclonic Dystonia MetaADEDB
Myoclonus ADReCS
Myopathy Toxic MetaADEDB
Myotonia MetaADEDB
Nausea ADReCS
Neck Pain MetaADEDB
Neck Stiffness ADReCS
Necrosis MetaADEDB
Neonatal Disorder ADReCS
Nervous System Diseases MetaADEDB
Neumonia MetaADEDB
Neurobehavioral Manifestations MetaADEDB
Neuromuscular Block Prolonged MetaADEDB
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Nikolsky Sign MetaADEDB
Nodal Arrhythmia ADReCS
Nodal Tachycardia SIDER
Normochromic Normocytic Anaemia MetaADEDB
Nuchal Rigidity ADReCS
Nystagmus ADReCS
Nystagmus Pathologic MetaADEDB
Obstruction ADReCS
Obstructive Airways Disorder ADReCS
Oedema ADReCS
Oliguria ADReCS
Operative Haemorrhage MetaADEDB
Ophthalmoplegia MetaADEDB
Opioid-Related Disorders MetaADEDB
Opisthotonus ADReCS
Optic Ischaemic Neuropathy MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain ADReCS
Pain In Extremity ADReCS
Pain Postoperative MetaADEDB
Pancreatitis MetaADEDB
Paraesthesia ADReCS
Paralysis MetaADEDB
Parotid Gland Enlargement ADReCS
Pedal Pulse Absent MetaADEDB
Peritonitis Sclerosing MetaADEDB
Pharyngitis ADReCS
Phlebitis ADReCS
Photophobia MetaADEDB
Photosensitivity Disorders MetaADEDB
Plasminogen Decreased MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pneumothorax MetaADEDB
Polymyositis MetaADEDB
Post Procedural Complication MetaADEDB
Post Procedural Haematoma MetaADEDB
Post Procedural Haemorrhage MetaADEDB
Postoperative Complications MetaADEDB
Postoperative Nausea And Vomiting MetaADEDB
Potentiating Drug Interaction MetaADEDB
Procedural Complication MetaADEDB
Procedural Hypotension MetaADEDB
Procedural Nausea MetaADEDB
Propofol Infusion Syndrome MetaADEDB
Proteinuria MetaADEDB
Pruritus ADReCS
Psychomotor Agitation MetaADEDB
Psychotic Disorders MetaADEDB
Pulmonary Congestion MetaADEDB
Pulmonary Edema MetaADEDB
Pulmonary Function Test Decreased ADReCS
Pulmonary Oedema ADReCS
Pulmonary Toxicity MetaADEDB
Pyrexia ADReCS
Quadriplegia MetaADEDB
Rales MetaADEDB
Rash ADReCS
Reaction Perinatal SIDER
Redness SIDER
Reflex Abnormal MetaADEDB
Renal Failure ADReCS
Renal Impairment MetaADEDB
Renal Insufficiency MetaADEDB
Renal Tubular Necrosis MetaADEDB
Reperfusion Injury MetaADEDB
Residual Urine MetaADEDB
Respiration Disorders MetaADEDB
Respiratory Acidosis ADReCS
Respiratory Arrest MetaADEDB
Respiratory Depression ADReCS
Respiratory Disorder MetaADEDB
Respiratory Failure ADReCS
Respiratory Insufficiency MetaADEDB
Respiratory Rate Increased MetaADEDB
Retrognathia MetaADEDB
Reversible Posterior Leukoencephalopathy Syndrome MetaADEDB
Rhabdomyolysis ADReCS
Right Ventricular Failure ADReCS
Salivary Hypersecretion ADReCS
Scleral Oedema MetaADEDB
Seizures SIDER
Self-Medication MetaADEDB
Sepsis ADReCS
Sepsis Syndrome MetaADEDB
Septic Shock MetaADEDB
Seroma MetaADEDB
Serratia Infection MetaADEDB
Shivering ADReCS
Shock ADReCS
Sinus Arrest Cardiac MetaADEDB
Sinus Bradycardia MetaADEDB
Sjogren Syndrome MetaADEDB
Skin Diseases MetaADEDB
Sleep Apnea MetaADEDB
Sleep Disorders MetaADEDB
Sneezing ADReCS
Somnolence ADReCS
Spasm MetaADEDB
Sputum Culture Positive MetaADEDB
Status Epilepticus MetaADEDB
Stevens-Johnson Syndrome MetaADEDB
Stiffness SIDER
Stinging SIDER
Subarachnoid Haemorrhage MetaADEDB
Subendocardial Ischaemia MetaADEDB
Substance Withdrawal Syndrome MetaADEDB
Supraventricular Extrasystoles ADReCS
Supraventricular Tachycardia ADReCS
Sweating Increased SIDER
Syncope ADReCS
Syndrome MetaADEDB
Tachycardia ADReCS
Tachycardia Sinus MetaADEDB
Tachycardia Supraventricular MetaADEDB
Tachycardia Ventricular MetaADEDB
Tachypnoea ADReCS
Tetanus MetaADEDB
Therapy Non-Responder MetaADEDB
Thinking Abnormal ADReCS
Threatened Labour MetaADEDB
Throat Irritation ADReCS
Thrombophlebitis MetaADEDB
Thrombosis MetaADEDB
Tinnitus ADReCS
Torsades De Pointes MetaADEDB
Transaminases Increased MetaADEDB
Transverse Presentation MetaADEDB
Tremor ADReCS
Trismus MetaADEDB
Tryptase Increased MetaADEDB
Unresponsive To Stimuli MetaADEDB
Unspecified Condition Originating In The Perinatal Period SIDER
Upper Airway Obstruction ADReCS
Upper Gastrointestinal Bleeding MetaADEDB
Urinary Casts MetaADEDB
Urinary Retention ADReCS
Urine Abnormality ADReCS
Urine Analysis Abnormal ADReCS
Urine Colour Abnormal ADReCS
Urinoma MetaADEDB
Urosepsis MetaADEDB
Urticaria ADReCS
Vascular Diseases MetaADEDB
Vascular Pseudoaneurysm MetaADEDB
Vasculitis MetaADEDB
Vena Cava Thrombosis MetaADEDB
Venous Thrombosis MetaADEDB
Venous Thrombosis Limb MetaADEDB
Ventricular Bigeminy SIDER
Ventricular Extrasystoles ADReCS
Ventricular Fibrillation ADReCS
Ventricular Tachycardia ADReCS
Vessel Puncture Site Haematoma MetaADEDB
Visual Acuity Reduced ADReCS
Visual Impairment ADReCS
Vomiting ADReCS
Weakness SIDER
Weaning Failure MetaADEDB
Wheeze MetaADEDB
Wheezing ADReCS
Wound Secretion MetaADEDB
Wound Treatment MetaADEDB

InAADR: Drug-Protein-ADRs database