InAADR

Drug Information

Drug Name: Pimozide (2062-78-4)
PubChem ID: 16362
SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
InchiKey: YVUQSNJEYSNKRX-UHFFFAOYSA-N
Therapeutic Category: Anti-Dyskinesia Agents, Antipsychotic Agents, Central Nervous System Agents, Central Nervous System Depressants, Dopamine Agents, Dopamine Antagonists, Neurotransmitter Agents, Psychotropic Drugs, Tranquilizing Agents

Computed Drug Properties

Molecular Weight (dalton): 461.556
LogP: 5.857
Ring Count: 4
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 41.03

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Seizures G protein-activated inward rectifier potassium channel (P48549) Antipsychotic drugs also inhibited the cardiac-type GIRK1/4 heteromultimeric channels@underlies the side effect of seizures. [ ADR Type 1 ] Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes
Tachycardia G protein-activated inward rectifier potassium channel (P48549) In oocytes co-injected with GIRK1 and GIRK2 mRNAs@ application of thioridazine immediately caused a reduction of inward currents through the basally active GIRK channels@underlies the side effect of sinus tachycardia [ ADR Type 1 ] Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes
Ventricular Arrhythmia Beta-1 adrenergic receptor (P18090) Not Available Large-scale prediction and testing of drug activity on side-effect targets
Ventricular Arrhythmia Histamine H1 receptor (P35367) Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Torsade De Pointes Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abnormal Eeg MetaADEDB
Abnormal Movements MetaADEDB
Abortion Missed MetaADEDB
Abuse MetaADEDB
Accelerated Hypertension MetaADEDB
Accidental Exposure MetaADEDB
Accommodation Disorder ADReCS
Adenocarcinoma MetaADEDB
Adenopathy MetaADEDB
Adverse Reaction ADReCS
Affective Disorder MetaADEDB
Agitated MetaADEDB
Agitation ADReCS
Agranulocytosis ADReCS
Akathisia ADReCS
Akinesia ADReCS
Allergic Vasculitis MetaADEDB
Alveolitis MetaADEDB
Amenorrhoea ADReCS
Anaemia ADReCS
Anorexia ADReCS
Anxiety MetaADEDB
Anxiety Separation MetaADEDB
Aortic Stenosis MetaADEDB
Aplastic Anaemia ADReCS
Application Site Pain MetaADEDB
Arrhythmia MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Atherosclerosis MetaADEDB
Attempted Suicide MetaADEDB
Basal Ganglia Diseases MetaADEDB
Bladder Retention MetaADEDB
Blepharospasm MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Disorder SIDER
Blood Prolactin Increased MetaADEDB
Blood Sodium MetaADEDB
Blood Urea Increased MetaADEDB
Body Temperature Decreased ADReCS
Bradycardia MetaADEDB
Bradykinesia ADReCS
Breast Cancer MetaADEDB
Breast Cyst MetaADEDB
Breast Discharge ADReCS
Breast Disorder SIDER
Breath Sounds Abnormal MetaADEDB
Bronchitis MetaADEDB
Cardiac Disorder ADReCS
Cardiac Failure MetaADEDB
Cardiac Fibrillation ADReCS
Cardiac Ischemia MetaADEDB
Cardiomyopathy Alcoholic MetaADEDB
Catalepsy MetaADEDB
Cataplexy MetaADEDB
Cataract ADReCS
Chemotherapeutic Drug Level Increased MetaADEDB
Chest Infection MetaADEDB
Chest Pain ADReCS
Circumstance Or Information Capable Of Leading To Medication Error MetaADEDB
Cogwheel Rigidity ADReCS
Coma MetaADEDB
Complications Of Maternal Exposure To Therapeutic Drugs MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Connective Tissue Disorder SIDER
Constipation ADReCS
Convulsion ADReCS
Cor Pulmonale MetaADEDB
Coughing Blood MetaADEDB
Culture Positive MetaADEDB
Cyanosis MetaADEDB
Death Sudden Cardiac MetaADEDB
Deglutition Disorder MetaADEDB
Depression ADReCS
Depression Suicidal MetaADEDB
Depressive Disorder MetaADEDB
Dermatitis ADReCS
Dermatitis Medicamentosa MetaADEDB
Diarrhoea ADReCS
Disorder Renal MetaADEDB
Dizziness ADReCS
Dreaming Abnormal ADReCS
Drowsiness MetaADEDB
Drug Interaction MetaADEDB
Dry Mouth ADReCS
Dysgeusia ADReCS
Dysgraphia ADReCS
Dyskinesia ADReCS
Dyskinesia Drug-Induced MetaADEDB
Dysphagia ADReCS
Dysthymic Disorder MetaADEDB
Dystonia ADReCS
Echocardiogram Abnormal MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electrocardiogram Abnormal ADReCS
Electrocardiogram Change SIDER
Electrocardiogram Normal SIDER
Electrocardiogram Qrs Complex Abnormal MetaADEDB
Electrocardiogram Qt Prolonged SIDER
Electrocardiogram Repolarisation Abnormality MetaADEDB
Electrocardiogram U Wave Present SIDER
Electroencephalogram Abnormal ADReCS
Embolism Pulmonary MetaADEDB
Endocrine Disorder SIDER
Enterocolitis MetaADEDB
Enuresis MetaADEDB
Eosinophilia ADReCS
Epidermal Necrosis MetaADEDB
Epilepsy Tonic-Clonic MetaADEDB
Erectile Dysfunction ADReCS
Eructation ADReCS
Escherichia Infection MetaADEDB
Extensor Plantar Response MetaADEDB
Extrapyramidal Disorder ADReCS
Extrapyramidal Symptoms SIDER
Eye Disorder SIDER
Face Pain MetaADEDB
Faecal Incontinence ADReCS
Fat Tissue Increased MetaADEDB
Fatty Liver MetaADEDB
Galactorrhea MetaADEDB
Galactorrhoea ADReCS
Gastrointestinal Discomfort ADReCS
Gastrointestinal Disorder SIDER
Gingival Hyperplasia ADReCS
Grand Mal Convulsion ADReCS
Gynaecomastia ADReCS
Haematoma MetaADEDB
Haemolytic Anaemia ADReCS
Haemorrhage Rectum MetaADEDB
Headache ADReCS
Heart Rate Increased MetaADEDB
Helicobacter Gastritis MetaADEDB
Hepatitis Acute MetaADEDB
Hernia Hiatal MetaADEDB
Homicidal Ideation MetaADEDB
Hormone Level Abnormal SIDER
Hyperalbuminaemia MetaADEDB
Hyperhidrosis ADReCS
Hyperkeratosis MetaADEDB
Hyperkinesia ADReCS
Hyperkinesis MetaADEDB
Hyperprolactinaemia ADReCS
Hyperprolactinemia MetaADEDB
Hyperpyrexia ADReCS
Hyperreflexia ADReCS
Hypertension ADReCS
Hypochondriasis MetaADEDB
Hypokinesia MetaADEDB
Hyponatraemia ADReCS
Hypotension ADReCS
Hypothermia ADReCS
Hypothyroid MetaADEDB
Hypoxia MetaADEDB
Impotence ADReCS
Incontinence ADReCS
Increased Appetite ADReCS
Increased White Blood Cell Count MetaADEDB
Insomnia ADReCS
Intentional Drug Misuse MetaADEDB
International Normalised Ratio Increased MetaADEDB
Lethargy MetaADEDB
Leukopenia ADReCS
Lichenoid Keratosis MetaADEDB
Localised Infection MetaADEDB
Long Qt Syndrome MetaADEDB
Loss Of Libido ADReCS
Lung Cancer Metastatic MetaADEDB
Lung Edema MetaADEDB
Malignant Syndrome Nos SIDER
Mammary Neoplasms Experimental MetaADEDB
Maternal Drugs Affecting Foetus MetaADEDB
Melanoma MetaADEDB
Menstrual Disorder ADReCS
Mental Disorder SIDER
Mental Disorders MetaADEDB
Metabolic Syndrome MetaADEDB
Migraine MetaADEDB
Miosis MetaADEDB
Motor Restlessness SIDER
Movement Disorders MetaADEDB
Movements Involuntary SIDER
Muscle Rigidity ADReCS
Muscle Spasms ADReCS
Muscle Tightness ADReCS
Musculoskeletal Stiffness MetaADEDB
Myalgia ADReCS
Nausea ADReCS
Nervous System Disorder ADReCS
Neuroleptic Malignant Syndrome ADReCS
Neuromyopathy ADReCS
Nocturia ADReCS
Nosocomial Infection MetaADEDB
Nuchal Rigidity ADReCS
Oculogyration MetaADEDB
Oculogyric Crisis ADReCS
Opisthotonus ADReCS
Orthostatic Hypotension ADReCS
Ovarian Cyst MetaADEDB
Overdose MetaADEDB
Palpitations ADReCS
Pancytopenia ADReCS
Paranoid Disorders MetaADEDB
Parkinson MetaADEDB
Parkinsonian Disorders MetaADEDB
Parkinsonism ADReCS
Pco2 Decreased MetaADEDB
Pericardial Effusion MetaADEDB
Periorbital Oedema ADReCS
Personality Disorders MetaADEDB
Photophobia ADReCS
Pleural Effusion MetaADEDB
Pollakiuria ADReCS
Polyuria MetaADEDB
Posture Abnormal ADReCS
Protrusion Tongue ADReCS
Pruritus ADReCS
Psychotic Disorders MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Congestion MetaADEDB
Pulmonary Thrombosis MetaADEDB
Purpura ADReCS
Rash ADReCS
Resuscitation MetaADEDB
Salivary Hypersecretion ADReCS
Schizophrenia MetaADEDB
Sedation ADReCS
Seizures SIDER
Sialorrhea MetaADEDB
Skin Desquamation MetaADEDB
Skin Irritation ADReCS
Sleep Disorder MetaADEDB
Somnolence ADReCS
Speech Disorder ADReCS
Spots Before Eyes ADReCS
Subileus MetaADEDB
Substance-Related Disorders MetaADEDB
Surgery MetaADEDB
Syncope ADReCS
Tachycardia ADReCS
Tardive Dyskinesia ADReCS
Thirst ADReCS
Thrombocytopenic Purpura ADReCS
Tonic-Clonic Seizures SIDER
Torsade De Pointes ADReCS
Torsades De Pointes MetaADEDB
Torticollis ADReCS
Tourette Syndrome MetaADEDB
Toxic Skin Eruption MetaADEDB
Tremor ADReCS
Troponin Increased MetaADEDB
Ultrasound Doppler Normal MetaADEDB
Urinary Retention ADReCS
Urinary Tract Infection Bacterial MetaADEDB
Urticaria ADReCS
Vascular Purpura ADReCS
Ventricular Fibrillation ADReCS
Ventricular Tachycardia ADReCS
Vision Blurred ADReCS
Visual Impairment ADReCS
Vomiting ADReCS
Weight Decreased ADReCS
Weight Gain MetaADEDB
Weight Increased ADReCS
X-Ray Limb MetaADEDB

InAADR: Drug-Protein-ADRs database