| Drug Name: | Streptozocin (18883-66-4) |
|---|---|
| PubChem ID: | 45357367 |
| SMILES: | CN(C(=O)NC1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O)N=O |
| InchiKey: | ZSJLQEPLLKMAKR-UHEPRFFZSA-N |
| Therapeutic Category: | Antibiotics, Antineoplastic Agents |
| Molecular Weight (dalton) | : | 265.222 |
| LogP | : | -2.8909 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 8 |
| Hydrogen Bond Donor Count | : | 5 |
| Total Polar Surface Area | : | 151.92 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Phenytoin (57-41-0) | Abolish The Effects Of Streptozocin | Antagonistic | Unknown | Influence of diphenylhydantoin on the effect of streptozotocin |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Abnormalities In Kinase Activity | Insulin receptor tyrosine kinase substrate (Q9UHR4) | Insulin-receptor tyrosine kinase activity is regulated differently in liver and muscle associated with the abnormalities in kinase activity [ ADR Type 2 3 ] | Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats |
| Hyperinsulinemia | Insulin receptor tyrosine kinase substrate (Q9UHR4) | Insulin-receptor tyrosine kinase activity is regulated differently in liver and muscle and that the abnormalities in kinase activity associated with the obese Zucker rat are at least partly secondary to hyperinsulinemia [ ADR Type 2 3 ] | Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category