InAADR

Drug Information

Drug Name: Gefitinib (184475-35-2)
PubChem ID: 123631
SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
InchiKey: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 446.91
LogP: 4.2756
Ring Count: 3
Hydrogen Bond Acceptor Count: 7
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 68.74

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Abdominal Rigidity MetaADEDB
Abnormal Lfts MetaADEDB
Abscess Bacterial MetaADEDB
Abscess Limb MetaADEDB
Accident MetaADEDB
Acinetobacter Infection MetaADEDB
Acne ADReCS
Acute Febrile Neutrophilic Dermatosis MetaADEDB
Acute Myeloblastic Leukemia MetaADEDB
Acute Prerenal Failure MetaADEDB
Acute Promyelocytic Leukaemia MetaADEDB
Acute Respiratory Distress Syndrome ADReCS
Acute Respiratory Failure MetaADEDB
Adjustment Disorder MetaADEDB
Affective Disorder ADReCS
Alanine Aminotransferase Increased ADReCS
Allergic Alveolitis MetaADEDB
Allergy Test Positive MetaADEDB
Alopecia ADReCS
Alveolitis ADReCS
Amblyopia ADReCS
Amentia MetaADEDB
Anaemia ADReCS
Angioedema ADReCS
Angiopathy ADReCS
Anorectal Disorder ADReCS
Anorexia ADReCS
Antibody Test Abnormal MetaADEDB
Aortic Aneurysm SIDER
Aortic Dissection SIDER
Arachnoid Cyst MetaADEDB
Arrhythmia ADReCS
Arterial Thrombosis Limb MetaADEDB
Arthralgia ADReCS
Aspartate Aminotransferase Increase MetaADEDB
Aspartate Aminotransferase Increased ADReCS
Aspiration Pneumonia MetaADEDB
Asteatosis MetaADEDB
Asthenia ADReCS
Atelectasis MetaADEDB
Atrial Fibrillation ADReCS
Atrioventricular Block Complete MetaADEDB
Atrophy Of Skin MetaADEDB
Autonomic Neuropathy MetaADEDB
Bacteria Sputum Identified MetaADEDB
Bacteria Stool Identified MetaADEDB
Bacterial Pneumonia MetaADEDB
Belching MetaADEDB
Benign Intracranial Hypertension MetaADEDB
Bladder Constriction MetaADEDB
Bladder Tamponade MetaADEDB
Bleeding Gums MetaADEDB
Blepharitis ADReCS
Blood Alkaline Phosphatase Increased ADReCS
Blood Beta-D-Glucan Increased MetaADEDB
Blood Bilirubin Increased ADReCS
Blood Cholinesterase MetaADEDB
Blood Cholinesterase Abnormal MetaADEDB
Blood Creatinine ADReCS
Blood Creatinine Increased ADReCS
Blood Gases Abnormal MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Urea Abnormal ADReCS
Blood Urea Increased MetaADEDB
Body Temperature Increased ADReCS
Bone Cancer Metastatic MetaADEDB
Bone Infection MetaADEDB
Bone Marrow Disorder MetaADEDB
Brain Herniation MetaADEDB
Brain Hypoxia MetaADEDB
Brain Stem Haemorrhage MetaADEDB
Bronchial Infection MetaADEDB
Bronchiectasis MetaADEDB
Bronchioloalveolar Carcinoma MetaADEDB
Bronchopneumonia MetaADEDB
Bronchostenosis MetaADEDB
Bullous Impetigo MetaADEDB
Bundle Branch Block ADReCS
Burn Oesophageal MetaADEDB
Burning Sensation Mucosal MetaADEDB
C-Reactive Protein Increased MetaADEDB
Cancer Pain ADReCS
Candida Pneumonia MetaADEDB
Capillary Disorder MetaADEDB
Carcinoembryonic Antigen Increased MetaADEDB
Carcinoma MetaADEDB
Cardiac Disorder ADReCS
Cardiac Failure MetaADEDB
Cardiac Fibrillation ADReCS
Cardiopulmonary Failure MetaADEDB
Cellulitis ADReCS
Central Pontine Myelinolysis MetaADEDB
Cerebellar Infarction MetaADEDB
Cerebral Infarct MetaADEDB
Cerebrospinal Fluid Leakage MetaADEDB
Cervix Disorder MetaADEDB
Chapped Lips MetaADEDB
Chemical Cystitis MetaADEDB
Chest Infection MetaADEDB
Chest X-Ray Abnormal MetaADEDB
Choking Sensation MetaADEDB
Chronic Obstructive Airways Disease Exacerbated MetaADEDB
Chronic Respiratory Disease MetaADEDB
Colitis Erosive MetaADEDB
Colonic Obstruction MetaADEDB
Computerised Tomogram MetaADEDB
Concomitant Disease Aggravated MetaADEDB
Condition Aggravated MetaADEDB
Conduction Disorder ADReCS
Congestive Cardiomyopathy ADReCS
Conjunctival Deposit MetaADEDB
Conjunctival Ulcer MetaADEDB
Conjunctivitis ADReCS
Constipation ADReCS
Contracted Bladder MetaADEDB
Corneal Disorder ADReCS
Corneal Erosion ADReCS
Cough ADReCS
Coughing Blood MetaADEDB
Cranial Neuropathy MetaADEDB
Creutzfeldt-Jakob Disease MetaADEDB
Cryptogenic Organising Pneumonia MetaADEDB
Csf Cell Count MetaADEDB
Csf Protein Increased MetaADEDB
Csf Test Abnormal MetaADEDB
Culture Positive MetaADEDB
Cutaneous Mycosis MetaADEDB
Cutaneous Ulcer MetaADEDB
Cutaneous Vasculitis PROTECT
Cystitis PROTECT
Cystitis Interstitial MetaADEDB
Deafness Bilateral MetaADEDB
Deafness Neurosensory ADReCS
Death ADReCS
Decreased Appetite ADReCS
Deep Thrombophlebitis SIDER
Deep Vein Thrombosis ADReCS
Deglutition Disorder MetaADEDB
Dehydration ADReCS
Dental Plaque MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Dermatitides MetaADEDB
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Dermatitis Exfoliative ADReCS
Dermatitis Seborrheic MetaADEDB
Dermatosis MetaADEDB
Detached Retina MetaADEDB
Diabetes Insipidus MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diffuse Alveolar Damage MetaADEDB
Disease Of Liver MetaADEDB
Disease Progression MetaADEDB
Disorder Lung MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Drug Interaction SIDER
Drug Interaction Potentiation MetaADEDB
Dry Eye PROTECT
Dry Mouth PROTECT
Dry Skin ADReCS
Duodenal Perforation MetaADEDB
Duodenal Ulcer Haemorrhage MetaADEDB
Dyspnoea ADReCS
Dyspnoea Exacerbated MetaADEDB
Effusion ADReCS
Electrocardiogram Qt Corrected Interval Prolonged SIDER
Electrocardiogram Qt Prolonged ADReCS
Electrolyte Disorder MetaADEDB
Electrolyte Disturbance SIDER
Electrolyte Imbalance ADReCS
Embolism Pulmonary MetaADEDB
Emesis MetaADEDB
Empyema MetaADEDB
Enterocolitis MetaADEDB
Enterocolitis Infectious MetaADEDB
Eosinophilic Pneumonia MetaADEDB
Epidermal Necrosis ADReCS
Epistaxis ADReCS
Erosive Oesophagitis MetaADEDB
Eruption SIDER
Erythema ADReCS
Erythema Multiforme ADReCS
Escherichia Bacteraemia MetaADEDB
Escherichia Infection MetaADEDB
Eye Haemorrhage ADReCS
Eye Pain ADReCS
Eye Pruritus MetaADEDB
Eyelash Thickening ADReCS
Eyelid Irritation MetaADEDB
Eyelid Pain MetaADEDB
Eyelid Retraction MetaADEDB
Fat Embolism MetaADEDB
Fatigue ADReCS
Febrile Neutropenia ADReCS
Feeding Tube Complication MetaADEDB
Fibrosis ADReCS
Folliculitis MetaADEDB
Food Intolerance MetaADEDB
Food Poisoning MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gangrene ADReCS
Gas Gangrene MetaADEDB
Gastric Mucosal Lesion MetaADEDB
Gastric Ulcer Perforated MetaADEDB
Gastrointestinal Disorder SIDER
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Motility Disorder MetaADEDB
Gastrointestinal Mucosal Disorder MetaADEDB
Gastrointestinal Pain ADReCS
Gastrointestinal Perforation PROTECT
Gastrointestinal Ulcer Perforation MetaADEDB
General Physical Health Deterioration MetaADEDB
Gingivitis Ulcerative MetaADEDB
Glossitis MetaADEDB
Glossopharyngeal Nerve Disorder MetaADEDB
Growth Accelerated MetaADEDB
Growth Of Eyelashes ADReCS
Haematemesis MetaADEDB
Haematuria ADReCS
Haemoglobin ADReCS
Haemolytic Uraemic Syndrome ADReCS
Haemoptysis ADReCS
Haemorrhage ADReCS
Hair Colour Changes MetaADEDB
Hair Growth Abnormal MetaADEDB
Hair Texture Abnormal MetaADEDB
Hangnail MetaADEDB
Headache ADReCS
Henoch-Schonlein Purpura MetaADEDB
Hepatic Fibrosis MetaADEDB
Hepatic Function Abnormal MetaADEDB
Hepatitis PROTECT
Hepatitis A Positive MetaADEDB
Hepatitis B Positive MetaADEDB
Hepatotoxicity ADReCS
Hiccough MetaADEDB
Hordeolum MetaADEDB
Humerus Fracture MetaADEDB
Hydropneumothorax MetaADEDB
Hyperglycaemia ADReCS
Hypersensitivity ADReCS
Hypocalcaemia ADReCS
Hypoglobulinaemia MetaADEDB
Hypokalaemia ADReCS
Hypomagnesaemia ADReCS
Hypoprothrombinaemia MetaADEDB
Hypotension ADReCS
Hypoxia ADReCS
Ichthyosis MetaADEDB
Idiopathic Pulmonary Fibrosis ADReCS
Iga Nephropathy MetaADEDB
Ild MetaADEDB
Ileal Ulcer MetaADEDB
Impaired Self-Care MetaADEDB
Impetigo MetaADEDB
Implant Site Erosion MetaADEDB
Increased Bronchial Secretion MetaADEDB
Increased Upper Airway Secretion MetaADEDB
Infected Epidermal Cyst MetaADEDB
Infection ADReCS
Infestation SIDER
Infestation Nos SIDER
Ingrowing Nail MetaADEDB
Ingrown Hair MetaADEDB
Injection Site Reaction ADReCS
Injury ADReCS
International Normalised Ratio Increased ADReCS
Interstitial Lung Disease ADReCS
Interstitial Pneumonia SIDER
Intestinal Obstruction MetaADEDB
Intracranial Tumour Haemorrhage MetaADEDB
Ischaemia ADReCS
Jejunal Stenosis MetaADEDB
Kaolin Cephalin Clotting Time Prolonged MetaADEDB
Keratitis PROTECT
Keratitis Sicca MetaADEDB
Large Intestinal Ulcer MetaADEDB
Laryngeal Granuloma MetaADEDB
Leukoencephalopathy MetaADEDB
Leukopenia ADReCS
Liver Function Test Abnormal ADReCS
Lower Gastrointestinal Haemorrhage MetaADEDB
Lung Adenocarcinoma MetaADEDB
Lung Adenocarcinoma Metastatic MetaADEDB
Lung Adenocarcinoma Recurrent MetaADEDB
Lung Adenocarcinoma Stage Ii MetaADEDB
Lung Cancer Metastatic MetaADEDB
Lung Carcinoma Cell Type Unspecified Recurrent MetaADEDB
Lung Consolidation MetaADEDB
Lung Disorder ADReCS
Lung Edema MetaADEDB
Lung Fibrosis MetaADEDB
Lung Infection MetaADEDB
Lung Infiltration MetaADEDB
Lung Injury MetaADEDB
Lung Neoplasm MetaADEDB
Lung Neoplasm Malignant MetaADEDB
Lung Squamous Cell Carcinoma Recurrent MetaADEDB
Lung Squamous Cell Carcinoma Stage Unspecified MetaADEDB
Lymphangiosis Carcinomatosa MetaADEDB
Lymphangitis MetaADEDB
Lymphocyte Morphology Abnormal MetaADEDB
Lymphocytosis MetaADEDB
Macular Oedema MetaADEDB
Malignant Neoplasm Of Spinal Cord MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Malignant Pleural Effusion MetaADEDB
Markedly Reduced Dietary Intake MetaADEDB
Mediastinal Disorder SIDER
Melaena ADReCS
Meningitides MetaADEDB
Mesenteric Vascular Insufficiency MetaADEDB
Metastases To Adrenals MetaADEDB
Metastases To Bone Marrow MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Chest Wall MetaADEDB
Metastases To Eye MetaADEDB
Metastases To Liver MetaADEDB
Metastases To Lung MetaADEDB
Metastases To Lymph Nodes MetaADEDB
Metastases To Meninges MetaADEDB
Metastases To Spine MetaADEDB
Middle Ear Inflammation MetaADEDB
Moraxella Infection MetaADEDB
Mouth Ulceration ADReCS
Mucosal Inflammation MetaADEDB
Mucous Membrane Disorder MetaADEDB
Myalgia ADReCS
Mycetoma Mycotic MetaADEDB
Mycobacterial Infection MetaADEDB
Myelitis MetaADEDB
Myelodysplasia MetaADEDB
Myelopathy MetaADEDB
Myocardial Infarction ADReCS
Myringitis MetaADEDB
Nail Discolouration MetaADEDB
Nail Disorder ADReCS
Nail Infection MetaADEDB
Nail Tinea MetaADEDB
Nasal Discomfort MetaADEDB
Nausea ADReCS
Necrolysis Epidermal SIDER
Neoplasm Progression MetaADEDB
Neumonia MetaADEDB
Neuritis ADReCS
Neutropenia ADReCS
Neutrophil Toxic Granulation Present MetaADEDB
Nodule MetaADEDB
Non-Small Cell Lung Cancer MetaADEDB
Non-Small Cell Lung Cancer Recurrent MetaADEDB
Nuclear Magnetic Resonance Imaging Brain Abnormal MetaADEDB
Obstructive Uropathy MetaADEDB
Occult Blood MetaADEDB
Ocular Ischaemic Syndrome ADReCS
Ocular Vascular Disorder ADReCS
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophageal Varices Haemorrhage MetaADEDB
Oesophagitis Ulcerative MetaADEDB
Onychoclasis MetaADEDB
Onychomadesis MetaADEDB
Oral Intake Reduced MetaADEDB
Oral Mucosal Petechiae MetaADEDB
Otitis Media Chronic MetaADEDB
Ovarian Mass MetaADEDB
Overgrowth Bacterial MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain ADReCS
Pancreatic Insufficiency MetaADEDB
Pancreatitis ADReCS
Paraesthesia ADReCS
Paraneoplastic Cerebellar Degeneration MetaADEDB
Paronychia ADReCS
Pco2 Decreased MetaADEDB
Pco2 Increased MetaADEDB
Pemphigus MetaADEDB
Performance Status Decreased MetaADEDB
Perianal Abscess MetaADEDB
Pericardial Effusion MetaADEDB
Peripheral Motor Neuropathy ADReCS
Peripheral Sensory Neuropathy ADReCS
Peripheral Vascular Disorder ADReCS
Peritoneal Carcinoma MetaADEDB
Peritoneal Disorder MetaADEDB
Peritonitis Sclerosing MetaADEDB
Petechia MetaADEDB
Pharyngeal Fistula MetaADEDB
Pharyngitis ADReCS
Platelet Transfusion ADReCS
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pleural Mesothelioma MetaADEDB
Pleurodesis MetaADEDB
Pneumatosis MetaADEDB
Pneumoconiosis ADReCS
Pneumocystis Carinii Pneumonia MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumomediastinum MetaADEDB
Pneumonia ADReCS
Pneumonia Cytomegaloviral MetaADEDB
Pneumonitis ADReCS
Pneumothorax MetaADEDB
Po2 Decreased MetaADEDB
Poisoning ADReCS
Post Procedural Diarrhoea MetaADEDB
Post Procedural Nausea MetaADEDB
Post Procedural Vomiting MetaADEDB
Postrenal Failure MetaADEDB
Procedural Hypertension MetaADEDB
Proctitis MetaADEDB
Productive Cough MetaADEDB
Proteinuria ADReCS
Pruritus ADReCS
Pubic Rami Fracture MetaADEDB
Pulmonary Alveolar Haemorrhage MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Bulla MetaADEDB
Pulmonary Fibrosis ADReCS
Pulmonary Haemorrhage ADReCS
Pulmonary Oedema ADReCS
Pulmonary Radiation Injury MetaADEDB
Pulmonary Toxicity ADReCS
Pyothorax MetaADEDB
Pyrexia ADReCS
Radiation Myelopathy MetaADEDB
Radiation Oesophagitis MetaADEDB
Radiation Pneumonitis MetaADEDB
Radiation Skin Injury MetaADEDB
Rales MetaADEDB
Rash ADReCS
Rash Pustular ADReCS
Recall Phenomenon ADReCS
Rectal Disorder SIDER
Recurrent Cancer MetaADEDB
Refusal Of Treatment By Patient MetaADEDB
Refusal Of Treatment By Relative MetaADEDB
Renal Failure ADReCS
Renal Function Test Abnormal MetaADEDB
Renal Impairment MetaADEDB
Renal Tubular Acidosis MetaADEDB
Respiratory Failure ADReCS
Retinal Bleeding MetaADEDB
Retinal Exudates MetaADEDB
Retinal Vasculitis MetaADEDB
Retinal Vein Thrombosis MetaADEDB
Retinitis MetaADEDB
Scrotal Oedema ADReCS
Seborrhoeic Dermatitis ADReCS
Secretion Discharge MetaADEDB
Serratia Infection MetaADEDB
Shock ADReCS
Sinoatrial Node Dysfunction ADReCS
Sinus Arrhythmia ADReCS
Skin Bleeding MetaADEDB
Skin Chapped MetaADEDB
Skin Erosion MetaADEDB
Skin Fissures PROTECT
Skin Reaction ADReCS
Skin Toxicity MetaADEDB
Skin Wrinkling MetaADEDB
Somnolence ADReCS
Sputum Culture Positive MetaADEDB
Sputum Retention MetaADEDB
Staphylococcal Infection MetaADEDB
Stenotrophomonas Infection MetaADEDB
Stevens-Johnson Syndrome PROTECT
Stomatitis ADReCS
Subdural Haemorrhage MetaADEDB
Subileus MetaADEDB
Superior Vena Cava Syndrome MetaADEDB
Therapeutic Response Unexpected MetaADEDB
Therapy Non-Responder MetaADEDB
Thrombocytopenia ADReCS
Thrombophlebitis ADReCS
Tongue Disorder MetaADEDB
Tongue Haemorrhage MetaADEDB
Toxic Dilatation Of Colon MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Transaminases Abnormal ADReCS
Tumour Associated Fever MetaADEDB
Tumour Embolism MetaADEDB
Tumour Marker Increased MetaADEDB
Ulcer ADReCS
Urinary Tract Disorder MetaADEDB
Urine Ketone Body Present MetaADEDB
Urogram Abnormal MetaADEDB
Urticaria ADReCS
Vaginal Disorder MetaADEDB
Vena Cava Injury MetaADEDB
Venoocclusive Liver Disease ADReCS
Vesiculobullous Rash SIDER
Vomiting ADReCS
Vulvovaginal Discomfort MetaADEDB
Walking Disability MetaADEDB
Weight Decreased ADReCS
Wound Infection Pseudomonas MetaADEDB
Zinc Deficiency MetaADEDB

InAADR: Drug-Protein-ADRs database