This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
| Amitriptyline (50-48-6) | Serotonin Syndrome | Synergistic | Not fully understood | Linezolid: MAOI activity and potential drug interactions
|
| Citalopram (59729-33-8) | Agitation | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Citalopram (59729-33-8) | Confusion | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Citalopram (59729-33-8) | Dysarthria | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Citalopram (59729-33-8) | Hyperreflexia | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Citalopram (59729-33-8) | Restlessness | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Citalopram (59729-33-8) | Serotonin Syndrome | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Citalopram (59729-33-8) | Tremor | Synergistic | Not fully understood | Serotonin syndrome and linezolid (Pubmed ID 15213578)
|
| Dextromethorphan (125-71-3) | Serotonin Syndrome | Synergistic | concurrent use of linezolid and dextromethorphan resulted in the serotonin syndrome.2 Linezolid has mild reversible MAOI activity, and the serotonin syndrome has been described when dextromethorphan was taken by patients also taking antidepressant MAOIs | Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr
|
| Fluoxetine (54910-89-3) | Hypertension | Synergistic | Not fully understood | Worldwide assessment of linezolid's clinical safety and tolerability: comparator-controlled phase III studies
|
| Fluoxetine (54910-89-3) | Serotonin Syndrome | Synergistic | Not fully understood | Worldwide assessment of linezolid's clinical safety and tolerability: comparator-controlled phase III studies
|
| Mirtazapine (61337-67-5) | Confusion | Synergistic | Not fully understood | Linezolid: MAOI activity and potential drug interactions
|
| Mirtazapine (61337-67-5) | Delirium | Synergistic | Not fully understood | Linezolid: MAOI activity and potential drug interactions
|
| Mirtazapine (61337-67-5) | Serotonin Syndrome | Synergistic | Not fully understood | Linezolid: MAOI activity and potential drug interactions
|
| Mirtazapine (61337-67-5) | Visual Hallucinations | Synergistic | Not fully understood | Linezolid: MAOI activity and potential drug interactions
|
| Paroxetine (61869-08-7) | Serotonin Syndrome | Synergistic | Not fully understood | Serotonin syndrome and linezolid
|
| Phenylpropanolamine (14838-15-4) | Hypertension | Additive | Linezolid acts as a weak MAO-inhibitor, which allows the accumulation of some noradrenaline at adrenergic nerve endings associated with arterial blood vessels. Phenylpropanolamine is indirectly- acting sympathomimetic, can release these above-normal amounts of noradrenaline resulting in blood vessel constriction and a rise in blood pressure | Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr
|
| Pseudoephedrine (90-82-4) | Hypertension | Additive | Linezolid acts as a weak MAO-inhibitor, which allows the accumulation of some noradrenaline at adrenergic nerve endings associated with arterial blood vessels. Pseudoephidrine is indirectly- acting sympathomimetic, can release these above-normal amounts of noradrenaline resulting in blood vessel constriction and a rise in blood pressure | Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr
|
| Sertraline (79617-96-2) | Serotonin Syndrome | Synergistic | Not fully understood | Linezolid and serotonin syndrome
|
| Venlafaxine (93413-69-5) | Disorientated | Synergistic | Not fully understood | Linezolid, a monoamine oxidase inhibiting antibiotic, and antidepressants
|
| Venlafaxine (93413-69-5) | Serotonin Syndrome | Synergistic | Not fully understood | Linezolid, a monoamine oxidase inhibiting antibiotic, and antidepressants
|