| Drug Name: | Halothane (151-67-7) |
|---|---|
| PubChem ID: | 3562 |
| SMILES: | C(C(F)(F)F)(Cl)Br |
| InchiKey: | BCQZXOMGPXTTIC-UHFFFAOYSA-N |
| Therapeutic Category: | Anesthetics, Central Nervous System Agents, Central Nervous System Depressants |
| Molecular Weight (dalton) | : | 197.381 |
| LogP | : | 2.5085 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 0 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 0 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Amiodarone (1951-25-3) | Vasodilator Effects | Additive | In vitro and in vivo studies in animals suggest that amiodarone has additive cardiodepressant and vasodilator effects with volatile anaesthetics such as halothane, enflurane and isoflurane | Should oral amiodarone be used for sustained ventricular tachycardia in patients requiring open-heart surgery? |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Hepatotoxicity | Alanine aminotransferase (P24298) | Increases in serum enzyme activities of the alanine aminotransferase (GPT) and the sorbitol dehydrogenase (SDH) were evident immediately following exposure and were six-fold higher@which leads to halothane hepatotoxicity [ ADR Type 2 ] | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model |
| Hepatotoxicity | CYP2A6 (P11509) | Both P450 2E1 and P450 2A6 participate in human halothane metabolism@ and that P450 2E1 is the predominant catalytic isoform | |
| Hepatotoxicity | Cytochrome P450 2E1 (P05181) | Both P450 2E1 and P450 2A6 participate in human halothane metabolism@ and that P450 2E1 is the predominant catalytic isoform. [ ADR Type 2 ] | Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro |
| Hepatotoxicity | Sorbitol dehydrogenase (Q00796) | Increases in serum enzyme activities of the alanine aminotransferase (GPT) and the sorbitol dehydrogenase (SDH) were evident immediately following exposure and were six-fold higher@which leads to halothane hepatotoxicity. [ ADR Type 2 ] | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model |
| Liver Cell Necrosisand Mitoses | Alanine aminotransferase (P24298) | Focal liver cell necrosisand occasional mitoses [ ADR Type 2 ] | Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure |
| Liver Cells Fatty Change | Alanine aminotransferase (P24298) | Many liver cells showed fatty change. [ ADR Type 2 ] | Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure |
| Lobular Disarray | Alanine aminotransferase (P24298) | Considerable lobular disarray [ ADR Type 2 ] | Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure |
| Porcine Stress Syndrome | Alanine aminotransferase (P24298) | Serum alanine aminotransferase increased in only those animals sacrificed at 24 hrs@ which leads to halothane induced porcine stress syndrome [ ADR Type 1 ] | Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category