This panel provides drug-protein interaction and their ADRs along with references
Toxicity |
Interacting Protein |
Mechanism |
Reference |
Fever | Alkaline phosphatase (P05187) | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced fever. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Fever | C-reactive protein (P02741) | The elevation of glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP), and gamma glutamyltrans peptidase (gamma-GTP), C reactive protein (CRP), and blood sedimentation rate (BSR),suggest strongly that 0 5% lidocaine induced fever [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Fever | Gamma-glutamyltranspeptidase (P19440) | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced fever. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Fever | Glutamate pyruvate transaminase (Q28DB5) | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced fever. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Hepatitis | Alkaline phosphatase (P05187) | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0 5% lidocaine induced hepatitis [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Hepatitis | C-reactive protein (P02741) | The elevation of glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP), and gamma glutamyltrans peptidase (gamma-GTP), C reactive protein (CRP), and blood sedimentation rate (BSR),suggest strongly that 0 5% lidocaine induced hepatitis [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Hepatitis | Gamma-glutamyltranspeptidase (P19440) | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced hepatitis. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Hepatitis | Glutamate pyruvate transaminase (Q28DB5) | The elevation of glutamic oxalacetic transaminase (GOT)@ glutamic pyruvic transaminase (GPT)@ alkaline phosphatase (ALP)@ and gamma glutamyltrans peptidase (gamma-GTP)@ C reactive protein (CRP)@ and blood sedimentation rate (BSR)@suggest strongly that 0.5% lidocaine induced hepatitis. [ ADR Type 2 ] | Unknown fever and abnormal liver functions after repeated epidural blocks with lidocaine for management of herpes zoster pain
|
Intestinal Disorder | glucose-regulated protein (P11021) | The acquisition of normal trafficking and function appears to utilize several cycles of anterograde and retrograde steps between the endoplasmic reticulum and the GOlgi implicating the molecular chaperones calnexin and heavy chain-binding protein implicate a temperature-sensitive mutation in an intestinal enzyme deficiency or an intestinal disorder [ ADR Type 3 ] | A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the endoplasmic reticulum and cis-Golgi
|
Lidocaine Tolerance | Alpha-1-acid glycoprotein (P02763) | Lidocaine tolerance during fiber-optic bronchoscopy. [ ADR Type 2 ] | A Relationship between inflammation, alpha-1-acid glycoprotein and lidocaine tolerance during fiber-optic bronchoscopy
|