| Drug Name: | Delavirdine (136817-59-9) |
|---|---|
| PubChem ID: | 5625 |
| SMILES: | CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C |
| InchiKey: | WHBIGIKBNXZKFE-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-HIV Agents, Anti-Infective Agents, Anti-Retroviral Agents, Antiviral Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors, Reverse Transcriptase Inhibitors |
| Molecular Weight (dalton) | : | 456.572 |
| LogP | : | 2.7171 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 110.43 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Methysergide (361-37-5) | Ergotism | Synergistic | The ergot alkaloids are mainly metabolised by the cytochrome P450 isoenzyme CYP3A4.Delavirdine is CYP3A4 inhibitor | Catalytic inhibition of human DNA topoisomerase II? by hypericin, a naphthodianthrone from St John’s wort (Hypericum perforatum) |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Severe Rash | Histamine H4 receptor (Q9H3N8) | Role of systems pharmacology in understanding drug adverse events |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category