InAADR

Drug Information

Drug Name: Tranexamic Acid (1197-18-8)
PubChem ID: 5526
SMILES: C1CC(CCC1CN)C(=O)O
InchiKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
Therapeutic Category: Antifibrinolytic Agents, Coagulants, Fibrin Modulating Agents, Hematologic Agents, Hemostatics

Computed Drug Properties

Molecular Weight (dalton): 157.213
LogP: 0.8361
Ring Count: 0
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 63.32

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Tretinoin (302-79-4) Kidney Cortex Necrosis Additive Tretinoin alone causes a procoagulant tendency in acute promyelocytic leukaemia (APL) and this may be exacerbated by use of antifibrinolytics. All-Trans Retinoic Acid (Atra) and Tranexamic Acid: A Potentially Fatal Combination In Acute Promyelocytic Leukaemia

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Infection MetaADEDB
Abdominal Pain ADReCS
Abdominal Tenderness MetaADEDB
Abnormal Behaviour MetaADEDB
Accident MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Brain Syndrome MetaADEDB
Acute Kidney Injury MetaADEDB
Acute Left Ventricular Failure MetaADEDB
Acute Myocardial Infarction MetaADEDB
Acute Promyelocytic Leukaemia MetaADEDB
Adenocarcinoma MetaADEDB
Adynamic Ileus MetaADEDB
Affect Lability MetaADEDB
Aggression MetaADEDB
Agranulocytoses MetaADEDB
Alanine Aminotransferase Abnormal MetaADEDB
Alanine Aminotransferase Increased MetaADEDB
Alcoholic Intoxication MetaADEDB
Alpha 1 Foetoprotein Increased MetaADEDB
Altered State Of Consciousness MetaADEDB
Amentia MetaADEDB
Anaemia ADReCS
Anaemia Of Chronic Disease MetaADEDB
Anaesthesia MetaADEDB
Anaphylactic Reaction MetaADEDB
Angioedema MetaADEDB
Angioimmunoblastic T-Cell Lymphoma MetaADEDB
Anorectal Operation MetaADEDB
Anti-Hbs Antibody Positive MetaADEDB
Antibody Test Abnormal MetaADEDB
Anticholinergic Syndrome MetaADEDB
Aortic Dilatation MetaADEDB
Arthralgia ADReCS
Ascites MetaADEDB
Aspartate Aminotransferase Abnormal MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Asphyxia MetaADEDB
Asthenia ADReCS
Atrophy MetaADEDB
Automatism MetaADEDB
Back Pain ADReCS
Bacterial Diarrhoea MetaADEDB
Bacterial Pneumonia MetaADEDB
Bacterial Toxaemia MetaADEDB
Bile Duct Obstruction MetaADEDB
Bile Duct Stone MetaADEDB
Binocular Eye Movement Disorder MetaADEDB
Black Stools MetaADEDB
Bladder Cancer MetaADEDB
Bladder Perforation MetaADEDB
Blast Cells Present MetaADEDB
Bleeding Vaginal MetaADEDB
Blindness ADReCS
Blood Albumin Decreased MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Beta-D-Glucan Increased MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Electrolytes Abnormal MetaADEDB
Blood Fibrinogen Increased MetaADEDB
Blood Glucose Decreased MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Smear Test Abnormal MetaADEDB
Blood Sodium MetaADEDB
Blood Urea Decreased MetaADEDB
Blood Urea Increased MetaADEDB
Blood Uric Acid MetaADEDB
Body Temperature Increased MetaADEDB
Bone Marrow Disorder MetaADEDB
Bone Marrow Transplant MetaADEDB
Bovine Tuberculosis MetaADEDB
Brain Death MetaADEDB
Brain Edema MetaADEDB
Brain Ischemia MetaADEDB
Brain Oedema MetaADEDB
Brain Stem Haemorrhage MetaADEDB
Brain Stem Syndrome MetaADEDB
Bronchoalveolar Lavage MetaADEDB
Bruxism MetaADEDB
C-Reactive Protein Increased MetaADEDB
Cachectic MetaADEDB
Calculus Urinary MetaADEDB
Carcinoid Syndrome MetaADEDB
Cardiogenic Shock MetaADEDB
Carotid Artery Thrombosis MetaADEDB
Cerebral Artery Thrombosis ADReCS
Cerebral Atrophy MetaADEDB
Cerebral Haemorrhage MetaADEDB
Cerebral Infarct MetaADEDB
Cerebral Infarction MetaADEDB
Cerebral Thrombosis ADReCS
Chemotherapeutic Drug Level Increased MetaADEDB
Chest X-Ray Abnormal MetaADEDB
Cholangiolitis MetaADEDB
Chromatopsia ADReCS
Clostridial Infection MetaADEDB
Clostridium Colitis MetaADEDB
Coagulation Factor Increased MetaADEDB
Coagulation Factor Ix Level Decreased MetaADEDB
Colitis Ischaemic MetaADEDB
Color Vision Defects MetaADEDB
Colorectal Cancer MetaADEDB
Coma MetaADEDB
Conjunctival Hyperaemia MetaADEDB
Consciousness Disorders MetaADEDB
Contracted Bladder MetaADEDB
Convulsion ADReCS
Convulsions Grand Mal MetaADEDB
Corneal Ulcer MetaADEDB
Coughing Blood MetaADEDB
Cramp Muscle SIDER
Cryoglobulinaemia MetaADEDB
Csf Monocyte Count Increased MetaADEDB
Deafness MetaADEDB
Deafness Unilateral MetaADEDB
Death MetaADEDB
Death Neonatal MetaADEDB
Decubitus Ulcer MetaADEDB
Deep Vein Thrombosis ADReCS
Delivery MetaADEDB
Dependence On Respirator MetaADEDB
Depression Suicidal MetaADEDB
Dermatitis ADReCS
Dermatitis Atopic ADReCS
Dermatitis Medicamentosa MetaADEDB
Device Ineffective MetaADEDB
Diabetes Insipidus MetaADEDB
Diabetes Mellitus Inadequate Control MetaADEDB
Diarrhoea ADReCS
Diastolic Dysfunction MetaADEDB
Disease Of Liver MetaADEDB
Disease Progression MetaADEDB
Disease Recurrence MetaADEDB
Disorder Lung MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Dizziness ADReCS
Drug Effect Decreased MetaADEDB
Drug Hypersensitivity MetaADEDB
Dry Skin MetaADEDB
Duodenal Ulcer MetaADEDB
Duodenal Ulcer Haemorrhage MetaADEDB
Duodenitis MetaADEDB
Dystonia MetaADEDB
Ear Infection MetaADEDB
Easy Bruisability MetaADEDB
Embolism ADReCS
Encephalomalacia MetaADEDB
Encephalopathy Hypertensive MetaADEDB
Endometrial Cancer MetaADEDB
Enterococcal Bacteraemia MetaADEDB
Enterocolitis MetaADEDB
Eosinophil Count Increased MetaADEDB
Eosinophilic Pneumonia MetaADEDB
Epiglottitis MetaADEDB
Epilepsy MetaADEDB
Epistaxis MetaADEDB
Erythema Induratum MetaADEDB
Erythema Multiforme MetaADEDB
Escherichia Bacteraemia MetaADEDB
Eye Diseases MetaADEDB
Factor Ix Inhibition MetaADEDB
Factor Viii Inhibition MetaADEDB
Fatigue ADReCS
Flooding MetaADEDB
Fluid Intake Reduced MetaADEDB
Foetal Distress Syndrome MetaADEDB
Fractured Skull Depressed MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gastric Cancer MetaADEDB
Gastric Ph Decreased MetaADEDB
Gastric Polyps MetaADEDB
Gastric Ulcer Haemorrhage MetaADEDB
Gastric Ulcer Perforated MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Disorder ADReCS
Gastrointestinal Necrosis MetaADEDB
Gastrointestinal Oedema MetaADEDB
Gastrointestinal Pain ADReCS
Gastrointestinal Stromal Tumour MetaADEDB
Gastrointestinal Symptom Nos SIDER
Gastrointestinal Toxicity MetaADEDB
Gaze Palsy MetaADEDB
Generalised Erythema MetaADEDB
Giddiness SIDER
Glossitis MetaADEDB
Glossoptosis MetaADEDB
Granulocyte Count Decreased MetaADEDB
Granulocytosis MetaADEDB
Haemarthrosis MetaADEDB
Haemodialysis MetaADEDB
Haemophilus Infection MetaADEDB
Haemorrhage Intracranial MetaADEDB
Haemorrhage Rectum MetaADEDB
Haemorrhagic Diathesis MetaADEDB
Head Injury MetaADEDB
Headache ADReCS
Hemiplegia MetaADEDB
Hemophilia A MetaADEDB
Hemorrhage MetaADEDB
Henoch-Schonlein Purpura MetaADEDB
Hepatic Function Abnormal MetaADEDB
Hepatic Lesion MetaADEDB
Hepatic Neoplasm Malignant MetaADEDB
Hepatic Neoplasm Malignant Non-Resectable MetaADEDB
Hepatitis Acute MetaADEDB
Hepatitis B Positive MetaADEDB
Hepatitis B Surface Antigen Positive MetaADEDB
Hepatitis C Rna Increased MetaADEDB
Hepatitis Fulminant MetaADEDB
Hepatocellular Damage MetaADEDB
Hiccough MetaADEDB
Hippocampal Sclerosis MetaADEDB
Hydrocephalus MetaADEDB
Hydronephrosis MetaADEDB
Hypercapnia MetaADEDB
Hypercoagulation MetaADEDB
Hyperventilation MetaADEDB
Hypoalbuminaemia MetaADEDB
Hypokalaemia MetaADEDB
Hypophosphataemia MetaADEDB
Hypoproteinaemia MetaADEDB
Hypotension ADReCS
Hypoxia MetaADEDB
Ild MetaADEDB
Immunodeficiency Common Variable MetaADEDB
Inappropriate Schedule Of Drug Administration MetaADEDB
Incorrect Drug Administration Duration MetaADEDB
Increased White Blood Cell Count MetaADEDB
Infarction MetaADEDB
Infection MetaADEDB
Injection Site Induration MetaADEDB
Injection Site Infection MetaADEDB
Intestinal Infarction MetaADEDB
Intracranial Aneurysm MetaADEDB
Intracranial Thrombosis MetaADEDB
Intracranial Tumour Haemorrhage MetaADEDB
Joint Stiffness MetaADEDB
Jugular Vein Thrombosis MetaADEDB
Kidney Cortex Necrosis MetaADEDB
Klebsiella Infection MetaADEDB
Klebsiella Sepsis MetaADEDB
Leiomyoma MetaADEDB
Lentigo MetaADEDB
Leukopenia Neonatal MetaADEDB
Lung Carcinoma Cell Type Unspecified Recurrent MetaADEDB
Lung Consolidation MetaADEDB
Lung Fibrosis MetaADEDB
Lung Neoplasm Malignant MetaADEDB
Lyell MetaADEDB
Lymph Node Tuberculosis MetaADEDB
Lymphocyte Morphology Abnormal MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Mania MetaADEDB
Mean Cell Haemoglobin Increased MetaADEDB
Mean Cell Volume Increased MetaADEDB
Menorrhagia MetaADEDB
Mesenteric Occlusion MetaADEDB
Metabolic Function Test MetaADEDB
Metastases To Abdominal Cavity MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Lung MetaADEDB
Metastases To Lymph Nodes MetaADEDB
Metastases To Spleen MetaADEDB
Migraine ADReCS
Motor Dysfunction MetaADEDB
Mucous Membrane Disorder MetaADEDB
Multiple Myeloma MetaADEDB
Multiple-Drug Resistance MetaADEDB
Muscle Spasms ADReCS
Musculoskeletal Discomfort ADReCS
Musculoskeletal Pain ADReCS
Myocardial Infarction MetaADEDB
Myocardial Rupture MetaADEDB
Myoclonic Epilepsy MetaADEDB
Myoclonus MetaADEDB
Nail Tinea MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Necrosis ADReCS
Necrosis Of Bronchioli MetaADEDB
Neumonia MetaADEDB
Neuropathic Pain MetaADEDB
Neutropenic Sepsis MetaADEDB
Neutrophil Count Decreased MetaADEDB
No Therapeutic Response MetaADEDB
Non-Small Cell Lung Cancer MetaADEDB
Nosocomial Infection MetaADEDB
Obstruction ADReCS
Oculomucocutaneous Syndrome MetaADEDB
Oesophageal Atresia MetaADEDB
Oesophagitis Haemorrhagic MetaADEDB
Oliguria MetaADEDB
Operative Haemorrhage MetaADEDB
Overdose MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain ADReCS
Pallor MetaADEDB
Panic Attack MetaADEDB
Paresis MetaADEDB
Peritonitis MetaADEDB
Peritonitis Bacterial MetaADEDB
Petechia MetaADEDB
Pharyngeal Erythema MetaADEDB
Pharyngeal Haemorrhage MetaADEDB
Pharyngeal Inflammation MetaADEDB
Pharyngolaryngeal Pain MetaADEDB
Phlebitis Infective MetaADEDB
Platelet Count MetaADEDB
Pneumocystis Carinii Pneumonia MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia Mycoplasmal MetaADEDB
Pneumonia Necrotising MetaADEDB
Post Procedural Haemorrhage MetaADEDB
Postoperative Complications MetaADEDB
Postoperative Renal Failure MetaADEDB
Postoperative Wound Infection MetaADEDB
Protein Total Decreased MetaADEDB
Prothrombin Level Decreased MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus Generalised MetaADEDB
Pseudomonal Bacteraemia MetaADEDB
Pulmonary Alveolar Haemorrhage MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Embolism ADReCS
Pulmonary Infarction MetaADEDB
Purpura Thrombocytopenic Idiopathic MetaADEDB
Pyelonephritis Acute MetaADEDB
Radiation Pneumonitis MetaADEDB
Rales MetaADEDB
Rash Generalised MetaADEDB
Rectal Perforation MetaADEDB
Reflux Esophagitis MetaADEDB
Refusal Of Treatment By Relative MetaADEDB
Reiter Syndrome MetaADEDB
Renal Cortical Necrosis ADReCS
Renal Insufficiency MetaADEDB
Renal Tubular Disorder MetaADEDB
Respiratory Disorder MetaADEDB
Respiratory Failure MetaADEDB
Retinal Artery Occlusion MetaADEDB
Retinal Artery Thrombosis ADReCS
Retinal Disorder ADReCS
Retinal Vein Occlusion MetaADEDB
Retroperitoneal Haematoma MetaADEDB
Rhabdomyolysis MetaADEDB
Rhinitis MetaADEDB
Road Traffic Accident MetaADEDB
Screaming MetaADEDB
Seizures MetaADEDB
Septic Shock MetaADEDB
Serum Sickness MetaADEDB
Shock Haemorrhagic MetaADEDB
Sinus Thrombosis Intracranial MetaADEDB
Sinusitis Bacterial MetaADEDB
Skin Laceration MetaADEDB
Small Intestinal Haemorrhage MetaADEDB
Spleen Congestion MetaADEDB
Sputum Culture Positive MetaADEDB
Status Epilepticus MetaADEDB
Stenotrophomonas Infection MetaADEDB
Streptococcal Infection MetaADEDB
Stroke MetaADEDB
Subarachnoid Hemorrhage MetaADEDB
Subclavian Vein Thrombosis MetaADEDB
Therapeutic Response Decreased MetaADEDB
Thromboembolic Event ADReCS
Thromboembolism MetaADEDB
Thrombosis ADReCS
Thrombotic Microangiopathy MetaADEDB
Tinea Pedis MetaADEDB
Tongue Biting MetaADEDB
Tooth Avulsion MetaADEDB
Transfusion Reaction MetaADEDB
Trigeminal Palsy MetaADEDB
Tuberculosis Bladder MetaADEDB
Tubulointerstitial Nephritis MetaADEDB
Ulcer MetaADEDB
Upper Airway Obstruction MetaADEDB
Urge Incontinence MetaADEDB
Urinary Sediment Abnormal MetaADEDB
Urine Amylase MetaADEDB
Uterine Hemorrhage MetaADEDB
Uterine Neoplasms MetaADEDB
Uterine Polyp MetaADEDB
Venoocclusive Liver Disease MetaADEDB
Venous Occlusion ADReCS
Venous Thrombosis ADReCS
Vesical Fistula MetaADEDB
Viral Mutation Identified MetaADEDB
Visual Acuity Reduced ADReCS
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vomiting ADReCS
Water Intoxication MetaADEDB

InAADR: Drug-Protein-ADRs database