| Drug Name: | Zafirlukast (107753-78-6) |
|---|---|
| PubChem ID: | 5717 |
| SMILES: | CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(C=C2)CC3=CN(C4=C3C=C(C=C4)NC(=O)OC5CCCC5)C)OC |
| InchiKey: | YEEZWCHGZNKEEK-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-Asthmatic Agents, Hormone Antagonists, Hormones, Leukotriene Antagonists, Respiratory System Agents |
| Molecular Weight (dalton) | : | 575.687 |
| LogP | : | 5.69592 |
| Ring Count | : | 4 |
| Hydrogen Bond Acceptor Count | : | 7 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 115.73 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Significant Increase In The Mean Auc And Half-Life Of S-Warfarin | Cytochrome P450 2C9 (P11712) | In a drug interaction study in 16 healthy male volunteers@ coadministration of multiple doses of zafirlukast (160 mg/day) to steady-state with a single 25 mg dose of warfarin resulted in a significant increase in the mean AUC (+63%) and half-life (+36%) of S-warfarin. The mean prothrombin time (PT) increased by approximately 35%. This interaction is probably due to an inhibition by zafirlukast of the cytochrome P450 2C9 isoenzyme system. [ ADR Type 4 ] | Warfarin interactions with chloral hydrate and glutethimide |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category