InAADR

Drug Information

Drug Name: Sibutramine (106650-56-0)
PubChem ID: 5210
SMILES: CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N(C)C
InchiKey: UNAANXDKBXWMLN-UHFFFAOYSA-N
Therapeutic Category: Anti-Obesity Agents, Antidepressive Agents, Appetite Depressants, Central Nervous System Agents, Psychotropic Drugs

Computed Drug Properties

Molecular Weight (dalton): 279.855
LogP: 4.738
Ring Count: 1
Hydrogen Bond Acceptor Count: 1
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 3.24

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Sertraline (79617-96-2) Serotonin Syndrome Additive Not Understood Chlorambucil/prednisone-induced seizures in a patient with non-Hodgkin's lymphoma

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Elevated Bp Interactions between grapefruit juice and cardiovascular drugs

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Hernia MetaADEDB
Abdominal infection MetaADEDB
Abdominal Mass MetaADEDB
Abdominal Neoplasm MetaADEDB
Abdominal Pain ADReCS
Abdominoplasty MetaADEDB
Abnormal Cervical Smear MetaADEDB
Abnormal Dreams ADReCS
Abnormal Ecg MetaADEDB
Abnormal Gait ADReCS
Abortion MetaADEDB
Abortion Induced MetaADEDB
Abortion Missed MetaADEDB
Abscess MetaADEDB
Accelerated Hypertension MetaADEDB
Acne ADReCS
Actinic Keratosis MetaADEDB
Acute Leukaemia MetaADEDB
Acute Psychosis MetaADEDB
Acute Pulmonary Oedema MetaADEDB
Acute Sinusitis MetaADEDB
Adenitis MetaADEDB
Adhesiolysis MetaADEDB
Adrenal Cortical Insufficiency MetaADEDB
Adrenal Neoplasm MetaADEDB
Adverse Drug Effect MetaADEDB
Affect Lability ADReCS
Agitated MetaADEDB
Agitation ADReCS
Allergic Reaction ADReCS
Allergic Rhinitis MetaADEDB
Allergic Vasculitis MetaADEDB
Allergy To Arthropod Sting MetaADEDB
Alopecia ADReCS
Alveoloplasty MetaADEDB
Amblyopia ADReCS
Amenorrhea MetaADEDB
Amnesia ADReCS
Amphetamines Positive MetaADEDB
Anaemia ADReCS
Anaemia Postoperative MetaADEDB
Anaphylactic Shock ADReCS
Anaphylactoid Reaction ADReCS
Anger ADReCS
Angina Pectoris ADReCS
Angina Unstable MetaADEDB
Angiopathy MetaADEDB
Anorectal Disorder ADReCS
Anorexia ADReCS
Anxiety ADReCS
Aortic Dilatation MetaADEDB
Aortic Rupture MetaADEDB
Appetite Disorder MetaADEDB
Aptyalism MetaADEDB
Arrested Labour MetaADEDB
Arrhythmia MetaADEDB
Arterial Disorder MetaADEDB
Arterial Thrombosis MetaADEDB
Arteriosclerosis Coronary Artery MetaADEDB
Arthralgia ADReCS
Arthritis ADReCS
Arthropathy ADReCS
Aseptic Necrosis Bone MetaADEDB
Asphyxia MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Atrial Fibrillation ADReCS
Atrial Tachycardia MetaADEDB
Atrioventricular Block First Degree MetaADEDB
Atrophy MetaADEDB
Aura MetaADEDB
Autoimmune Disorder MetaADEDB
Automatism MetaADEDB
Back Pain ADReCS
Bacteria Urine Identified MetaADEDB
Basedow Disease MetaADEDB
Benign Prostatic Hyperplasia MetaADEDB
Bereavement MetaADEDB
Binge Eating MetaADEDB
Biopsy MetaADEDB
Bladder Inflammation MetaADEDB
Bladder Retention MetaADEDB
Bleeding Gums MetaADEDB
Blood Bicarbonate Decreased MetaADEDB
Blood Chloride Increased MetaADEDB
Blood Cholesterol MetaADEDB
Blood Cholesterol Abnormal MetaADEDB
Blood Disorder MetaADEDB
Blood Pressure Fluctuation MetaADEDB
Blood Pressure Increased ADReCS
Blurred Vision MetaADEDB
Body Temperature Increased ADReCS
Bone Disorder MetaADEDB
Bone Neoplasm Malignant MetaADEDB
Bone Spur MetaADEDB
Bradypnoea MetaADEDB
Brain Damage MetaADEDB
Brain Neoplasm MetaADEDB
Breast Microcalcification MetaADEDB
Breast Neoplasm MetaADEDB
Bronchitis ADReCS
Bruxism MetaADEDB
Bulging MetaADEDB
Bundle Branch Block Left MetaADEDB
Bundle Branch Block Right MetaADEDB
Bursitis ADReCS
Caesarean Section MetaADEDB
Calcinosis MetaADEDB
Carcinoid Syndrome MetaADEDB
Cardiac Arrest ADReCS
Cardiac Decompensation MetaADEDB
Cardiac Disease MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure MetaADEDB
Cardiac Failure Congestive ADReCS
Cardiac Flutter MetaADEDB
Cardiovascular Disorder MetaADEDB
Carotid Artery Disease MetaADEDB
Carpal Tunnel MetaADEDB
Catatonia MetaADEDB
Catheter Placement MetaADEDB
Central Nervous System Stimulation ADReCS
Cerebral Ischaemia MetaADEDB
Cerebrovascular Accident ADReCS
Cervicitis MetaADEDB
Chest Pain ADReCS
Chest Pressure ADReCS
Chest Tightness ADReCS
Child Neglect MetaADEDB
Choking Sensation MetaADEDB
Cholecystitis ADReCS
Cholelithiasis ADReCS
Chorioamnionitis MetaADEDB
Chorioretinitis MetaADEDB
Circumstance Or Information Capable Of Leading To Medication Error MetaADEDB
Coagulation Factor Vii Level Increased MetaADEDB
Colon Spastic MetaADEDB
Colonic Polyp MetaADEDB
Colonoscopy MetaADEDB
Complications Of Maternal Exposure To Therapeutic Drugs MetaADEDB
Confusional State ADReCS
Congenital Jaw Malformation MetaADEDB
Congenital Mitral Valve Incompetence MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Conjunctivitis Infective MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Conversion Disorder MetaADEDB
Convulsion ADReCS
Cough ADReCS
Cough Increased ADReCS
Cramp Muscle SIDER
Cramps Of Lower Extremities SIDER
Cutaneous Ulcer MetaADEDB
Decreased Activity MetaADEDB
Decreased Appetite ADReCS
Delusion MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Depression ADReCS
Depression Aggravated ADReCS
Dermatitis ADReCS
Device Related Infection MetaADEDB
Diarrhoea ADReCS
Dilatation Ventricular MetaADEDB
Disease Recurrence MetaADEDB
Disorder Retinal MetaADEDB
Disturbance In Attention ADReCS
Diverticulum Intestinal Haemorrhagic MetaADEDB
Dizziness ADReCS
Drug Addict MetaADEDB
Drug Effect Decreased MetaADEDB
Drug Ineffective MetaADEDB
Drug Screen Positive MetaADEDB
Drug Therapy MetaADEDB
Drug Tolerance MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Eye ADReCS
Dry Mouth ADReCS
Duodenal Ulcer ADReCS
Dysgeusia ADReCS
Dysmenorrhoea ADReCS
Dyspepsia ADReCS
Dysphasia MetaADEDB
Dysphonia MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea ADReCS
Dysuria ADReCS
Ear Discomfort MetaADEDB
Ear Disorder ADReCS
Ear Pain ADReCS
Early Morning Awakening MetaADEDB
Ecchymosis ADReCS
Ecg Signs Of Ventricular Hypertrophy MetaADEDB
Eclampsia MetaADEDB
Ectopic Pregnancies MetaADEDB
Eczema ADReCS
Ejaculation Disorder ADReCS
Electrocardiogram Qt Prolonged MetaADEDB
Electrocardiogram St-T Change MetaADEDB
Electrocardiogram T Wave Abnormal MetaADEDB
Electromechanical Dissociation MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Elevated Mood MetaADEDB
Embolism MetaADEDB
Embolism Pulmonary MetaADEDB
Endometrial Cancer MetaADEDB
Epistaxis ADReCS
Erectile Dysfunction MetaADEDB
Eructation ADReCS
Excessive Thirst MetaADEDB
Exophthalmos MetaADEDB
Extrasystoles MetaADEDB
Extrasystoles Ventricular MetaADEDB
Extremity Pain MetaADEDB
Eye Pain ADReCS
Face Oedema ADReCS
Faecaloma MetaADEDB
Fallot Tetralogy MetaADEDB
Familial Mediterranean Fever MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue MetaADEDB
Feeling Abnormal MetaADEDB
Fibrin D Dimer MetaADEDB
Fibroids MetaADEDB
Flank Pain MetaADEDB
Flatulence ADReCS
Flooding MetaADEDB
Fluid Retention ADReCS
Food Craving MetaADEDB
Formication MetaADEDB
Gambling MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gangrene MetaADEDB
Gastric Hyperplasia MetaADEDB
Gastric Lavage MetaADEDB
Gastric Ulcer ADReCS
Gastritis ADReCS
Gastroenteritis ADReCS
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Pain ADReCS
Generalised Oedema ADReCS
Gingival Pain MetaADEDB
Glomerulonephritis MetaADEDB
Glomerulosclerosis MetaADEDB
Goiter MetaADEDB
Goitre ADReCS
Granuloma MetaADEDB
Haematemesis MetaADEDB
Haematuria ADReCS
Haemoglobin Increased MetaADEDB
Hair Growth Abnormal MetaADEDB
Headache ADReCS
Heart Injury MetaADEDB
Heart Rate Abnormal MetaADEDB
Heart Rate Decreased ADReCS
Heart Rate Increased MetaADEDB
Heart Transplant MetaADEDB
Hemicephalalgia MetaADEDB
Henoch-Schonlein Purpura MetaADEDB
Hepatic Pain MetaADEDB
Hepatitis Acute MetaADEDB
Hepatitis B Positive MetaADEDB
Hepatitis Fulminant MetaADEDB
Hernia MetaADEDB
Hernia Repair MetaADEDB
Herpes Nos SIDER
Herpes Simplex ADReCS
Herpes Virus Infection ADReCS
High Blood Pressure MetaADEDB
High Density Lipoprotein Increased MetaADEDB
Hip Surgery MetaADEDB
Hodgkin Disease MetaADEDB
Hydrothorax MetaADEDB
Hyperalimentation MetaADEDB
Hyperglycaemia ADReCS
Hyperhidrosis ADReCS
Hyperlipaemia MetaADEDB
Hypersensitivity ADReCS
Hypertension ADReCS
Hyperthyroidism ADReCS
Hypertonia ADReCS
Hypoaesthesia ADReCS
Hypoglycaemia ADReCS
Hypothyroidism ADReCS
Hypoxic Encephalopathy MetaADEDB
Idiopathic Thrombocytopenic Purpura MetaADEDB
Iliac Artery Stenosis MetaADEDB
Iliac Vein Occlusion MetaADEDB
Impotence ADReCS
Incision Site Complication MetaADEDB
Incontinence MetaADEDB
Increased Appetite ADReCS
Infection ADReCS
Infertility MetaADEDB
Influenza ADReCS
Injury ADReCS
Insomnia ADReCS
Intention Tremor MetaADEDB
Intestinal Obstruction ADReCS
Intracardiac Thrombus MetaADEDB
Intracranial Aneurysm MetaADEDB
Intraocular Pressure Increased ADReCS
Irregular Menstrual Cycle MetaADEDB
Joint Effusion MetaADEDB
Judgement Impaired MetaADEDB
Lack Of Satiety MetaADEDB
Laryngeal Stenosis MetaADEDB
Laryngitis ADReCS
Left Ventricular Dysfunction MetaADEDB
Leg Amputation MetaADEDB
Leg Cramps ADReCS
Leukopenia ADReCS
Libido Decreased ADReCS
Libido Increased ADReCS
Ligament Injury MetaADEDB
Limb Injury MetaADEDB
Localised Osteoarthritis MetaADEDB
Lymphadenopathy ADReCS
Lymphatic Obstruction MetaADEDB
Major Depression MetaADEDB
Malignant Hypertension MetaADEDB
Malignant Melanoma MetaADEDB
Malignant Neoplasm Of Spinal Cord MetaADEDB
Mania ADReCS
Mediastinitis MetaADEDB
Melanocytic Naevus MetaADEDB
Meningococcal Sepsis MetaADEDB
Menometrorrhagia MetaADEDB
Menstrual Disorder ADReCS
Mental Disability ADReCS
Metastases To Ovary MetaADEDB
Metastatic Renal Cell Carcinoma MetaADEDB
Metrorrhagia ADReCS
Migraine ADReCS
Mitral Valve Disease MetaADEDB
Monarthritis MetaADEDB
Monoplegia MetaADEDB
Mood Altered ADReCS
Mood Swings ADReCS
Mouth Ulceration ADReCS
Movement Disorder MetaADEDB
Mucosal Erosion MetaADEDB
Multi-Organ Failure MetaADEDB
Multiple Injuries MetaADEDB
Murder MetaADEDB
Muscle Spasms ADReCS
Muscle Strain MetaADEDB
Muscle Twitching ADReCS
Muscle Weakness MetaADEDB
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Mycobacterium Avium Complex Infection MetaADEDB
Myocardial Infarction ADReCS
Nasal Congestion ADReCS
Nasal Sinus Drainage MetaADEDB
Nausea ADReCS
Near Syncope MetaADEDB
Neck Pain ADReCS
Necrotising Granulomatous Lymphadenitis MetaADEDB
Nervous Tension MetaADEDB
Nervousness ADReCS
Neuralgia MetaADEDB
Neurogenic Bladder MetaADEDB
Nightmare ADReCS
Nocturia MetaADEDB
Nuclear Magnetic Resonance Imaging Abnormal MetaADEDB
Obstructive Uropathy MetaADEDB
Oedema ADReCS
Oedema Peripheral ADReCS
Oligohydramnios MetaADEDB
Oophorectomy MetaADEDB
Oral Discomfort MetaADEDB
Oral Polypectomy MetaADEDB
Orthopnea MetaADEDB
Osteoarthritis ADReCS
Otitis Externa ADReCS
Otitis Media ADReCS
Pain ADReCS
Pain In Extremity ADReCS
Pallor MetaADEDB
Palpitation MetaADEDB
Palpitations ADReCS
Pancreatic Carcinoma Metastatic MetaADEDB
Panic Disorder MetaADEDB
Panniculitis MetaADEDB
Paraesthesia ADReCS
Paranoia MetaADEDB
Pericardial Disease MetaADEDB
Pericardial Effusion MetaADEDB
Persecutory Delusion MetaADEDB
Personality Disorder MetaADEDB
Petechiae ADReCS
Phaeochromocytoma MetaADEDB
Pharyngitis ADReCS
Pharyngolaryngeal Pain MetaADEDB
Phlebitis MetaADEDB
Photosensitivity Reaction ADReCS
Physical Disability MetaADEDB
Pollakiuria ADReCS
Polycystic Ovaries MetaADEDB
Post Nasal Drip MetaADEDB
Postoperative Infection MetaADEDB
Postoperative Wound Infection MetaADEDB
Postpartum Depression MetaADEDB
Postpartum Disorder MetaADEDB
Precancerous Skin Lesion MetaADEDB
Pregnancy On Oral Contraceptive MetaADEDB
Pregnancy With Implant Contraceptive MetaADEDB
Prescribed Overdose MetaADEDB
Prinzmetal Angina MetaADEDB
Proctitis Herpes MetaADEDB
Productive Cough MetaADEDB
Prostate Cancer Metastatic MetaADEDB
Prostatitis MetaADEDB
Pruritus ADReCS
Psychoses MetaADEDB
Psychotic Disorder ADReCS
Pulmonary Congestion MetaADEDB
Pulmonary Hypertension MetaADEDB
Pulmonary Infarction MetaADEDB
Pyelonephritis MetaADEDB
Pyrexia ADReCS
Radiation Oesophagitis MetaADEDB
Radicular Syndrome MetaADEDB
Rash ADReCS
Rebound Hypertension MetaADEDB
Rectal Disorder SIDER
Red Blood Cell Sedimentation Rate Decreased MetaADEDB
Reflux Laryngitis MetaADEDB
Renal Artery Stenosis MetaADEDB
Renal Cancer MetaADEDB
Renal Infarct MetaADEDB
Renal Mass MetaADEDB
Respiratory Disorder ADReCS
Retinal Vein Occlusion MetaADEDB
Rhinitis ADReCS
Risus Sardonicus MetaADEDB
Salivary Hypersecretion ADReCS
Screaming MetaADEDB
Sensory Loss MetaADEDB
Sinus Headache MetaADEDB
Sinusitis ADReCS
Skin Lesion MetaADEDB
Sleep Apnea MetaADEDB
Small Intestinal Perforation MetaADEDB
Somnolence ADReCS
Speech Disorder ADReCS
Spondylosis MetaADEDB
Streptococcal Infection MetaADEDB
Stress MetaADEDB
Stress Symptoms MetaADEDB
Subarachnoid Haemorrhage MetaADEDB
Subcutaneous Nodule MetaADEDB
Subdural Haemorrhage MetaADEDB
Submandibular Mass MetaADEDB
Sudden Death ADReCS
Suicidal Behaviour MetaADEDB
Suicidal Ideation ADReCS
Suicide Attempt ADReCS
Supraventricular Tachycardia ADReCS
Sweating SIDER
Syncope ADReCS
Synovial Cyst MetaADEDB
Tachycardia ADReCS
Tachyphrenia MetaADEDB
Tenosynovitis ADReCS
Tension ADReCS
Thinking Abnormal ADReCS
Thirst ADReCS
Thrombocytopenia ADReCS
Thrombophlebitis MetaADEDB
Thyroid Adenoma MetaADEDB
Tinnitus ADReCS
Tongue Oedema ADReCS
Tonsillar Hypertrophy MetaADEDB
Tooth Disorder ADReCS
Torsade De Pointes ADReCS
Total Cholesterol/Hdl Ratio MetaADEDB
Tourette Disorder ADReCS
Toxic Encephalopathy MetaADEDB
Transient Ischaemic Attack ADReCS
Transposition Of The Great Vessels MetaADEDB
Tremor ADReCS
Tuberculin Test Positive MetaADEDB
Tubulointerstitial Nephritis ADReCS
Ulcer MetaADEDB
Ultrasound Liver Abnormal MetaADEDB
Unintended Pregnancy MetaADEDB
Unwanted Pregnancy MetaADEDB
Urethral Disorder MetaADEDB
Urinary Retention ADReCS
Urinary Tract Infection ADReCS
Urticaria ADReCS
Uterine Cancer MetaADEDB
Vascular Headache ADReCS
Vasculitis Gastrointestinal MetaADEDB
Vasodilation SIDER
Vasodilation Procedure ADReCS
Vasospasm MetaADEDB
Venous Insufficiency MetaADEDB
Venous Stenosis MetaADEDB
Venous Thrombosis Limb MetaADEDB
Ventricular Extrasystoles ADReCS
Ventricular Fibrillation ADReCS
Ventricular Hypokinesia MetaADEDB
Ventricular Tachycardia ADReCS
Vertigo ADReCS
Viral Upper Respiratory Tract Infection MetaADEDB
Vision Blurred ADReCS
Visual Disturbance MetaADEDB
Visual Impairment ADReCS
Vith Nerve Disorder MetaADEDB
Vocal Cord Polyp MetaADEDB
Vomiting ADReCS
Vulvovaginal Candidiasis ADReCS
Weight Abnormal MetaADEDB
Weight Gain MetaADEDB
Weight Loss Poor MetaADEDB
Wolff-Parkinson-White Syndrome MetaADEDB
Wound Dehiscence MetaADEDB
Wound Drainage MetaADEDB
Wound Infection MetaADEDB
Yawning ADReCS

InAADR: Drug-Protein-ADRs database