| Drug Name: | Glyburide (10238-21-8) |
|---|---|
| PubChem ID: | 3488 |
| SMILES: | COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
| InchiKey: | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| Therapeutic Category: | Hypoglycemic Agents |
| Molecular Weight (dalton) | : | 494.013 |
| LogP | : | 3.6417 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 113.6 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Haemolysis | Glucose-6-phosphate 1-dehydrogenase (P11413) | Glyburide-induced acute haemolysis in a glucose-6-phosphate dehydrogenase (G6PD) -deficient patient [ ADR Type 2 3 ] | Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM |
| Obesity-Prone | sulfonylurea receptors (Q09429) | Glucose may affect the firing of glucose-responsive neurons by indirectly altering KATP channel function via its effects on low-affinity cell body SUR. [ ADR Type 2 ] | In vivo and in vitro regulation of [3H]glyburide binding to brain sulfonylurea receptors in obesity-prone and resistant rats by glucose |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category