This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Antifibrogenic Action | Matrix metalloproteinase (P50281) | Incubation with PTF increased the levels of #activated MMP-1# in cell supernatants in both basal and stimulated conditions,suggest that the antifibrogenic action of PTF on human HSCs is mainly mediated by extracellular collagen degradation [ ADR Type 1 ] | Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta
|
| Antifibrogenic Action | Metalloproteinase inhibitor 1 (P01033) | PTF markedly reduced the expression of tissue inhibitor of metalloproteinase 1 (TIMP-1) mRNA,suggest that the antifibrogenic action of PTF on human HSCs is mainly mediated by extracellular collagen degradation. [ ADR Type 1 ] | Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta
|
| Endothelial Injury | Thrombomodulin (P07204) | Concentrations of thrombomodulin (TM) as a marker of endothelial injury [ ADR Type 2 ] | Cyclosporine-related encephalopathy following allogeneic bone marrow transplantation
|
| Inflammation | Interleukin-6 precursor (P05231) | PTX induced an up- or a down-regulation (in PMA + PHA or LPS stimulated cells, respectively) for IL-1 and IL-6 release,which plays a key role in inflammation [ ADR Type 5 ] | Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline
|
| Inflammation | Tumor necrosis factor precursor (P01375) | Expression and production of TNF alpha and TNF beta were inhibited by PTX in a dose-dependent manner,which plays a key role in inflammation. [ ADR Type 1 ] | Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline
|
| Inhibitory Effect | Perforin (P14222) | Anti-CD3-activated killer (AK) cell expression of the cytoplasmic granule-associated cytolytic effector molecules granzyme B and perforin was markedly reduced when AK cells were induced in the presence of Pentoxifylline(PTX),PTX thus has a profound inhibitory effect in vitro on the induction of granule-dependent cytolytic effector mechanisms in a mouse model system [ ADR Type 5 ] | Pentoxifylline inhibits granzyme B and perforin expression following T-lymphocyte activation by anti-CD3 antibody
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This panel provides drug-food interactions and their ADRs along with references
This panel provides information on drug category