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Drugs Causing Irritability: 193
Drug Name
CAS Number
Source
Agomelatine
138112-76-2
PROTECT
Alglucosidase alfa
420784-05-0
ADReCS
Alprazolam
28981-97-7
ADReCS
Alprostadil
745-65-3
ADReCS
Amantadine
768-94-5
ADReCS
Aminophylline
317-34-0
ADReCS
Amitriptyline
50-48-6
ADReCS
Amitriptyline Hydrochloride
549-18-8
MetaADEDB
Amphetamine
300-62-9
ADReCS
Apraclonidine
66711-21-5
ADReCS
Aripiprazole
129722-12-9
ADReCS
Asenapine
65576-45-6
ADReCS
Atomoxetine
83015-26-3
SIDER
Atomoxetine Hydrochloride
82248-59-7
ADReCS
Atropine
51-55-8
ADReCS
Azithromycin
83905-01-5
ADReCS
Betaine
107-43-7
ADReCS
Boceprevir
394730-60-0
ADReCS
Bortezomib
179324-69-7
PROTECT
Bosentan
147536-97-8
ADReCS
Brinzolamide
138890-62-7
PROTECT
Bromazepam
1812-30-2
ADReCS
Budesonide
51333-22-3
ADReCS
Bupropion
34841-39-9
ADReCS
Caffeine
58-08-2
ADReCS
Capecitabine
154361-50-9
ADReCS
Carbinoxamine
486-16-8
ADReCS
Carbinoxamine maleate
3505-38-2
SIDER
Carisoprodol
78-44-4
ADReCS
Ceftibuten
97519-39-6
ADReCS
Cefuroxime
55268-75-2
ADReCS
Cetirizine
83881-51-0
ADReCS
Cevimeline
107233-08-9
ADReCS
Chlorphenamine
132-22-9
ADReCS
Chorionic Gonadotropin
9002-61-3
ADReCS
Ciprofloxacin
85721-33-1
ADReCS
Cisplatin
15663-27-1
ADReCS
Clemastine
15686-51-8
ADReCS
Clobazam
22316-47-8
ADReCS
Clodronate
10596-23-3
ADReCS
Clofarabine
123318-82-1
ADReCS
Clomifene
911-45-5
ADReCS
Clomiphene citrate
50-41-9
SIDER
Clomipramine
303-49-1
ADReCS
Clonazepam
1622-61-3
ADReCS
Clonidine
4205-90-7
ADReCS
Clorazepate
23887-31-2
ADReCS
Clozapine
5786-21-0
ADReCS
Conjugated Estrogens
438-67-5
ADReCS
Corticotropin
12427-33-7
ADReCS
Cyclobenzaprine
303-53-7
ADReCS
Cycloserine
68-41-7
ADReCS
Cyproheptadine
129-03-3
ADReCS
Darifenacin
133099-04-4
ADReCS
Darunavir
206361-99-1
ADReCS
Desloratadine
100643-71-8
ADReCS
Desvenlafaxine
93413-62-8
ADReCS
Dexchlorpheniramine
25523-97-1
ADReCS
Dexmethylphenidate
40431-64-9
ADReCS
Diazepam
439-14-5
ADReCS
Diclofenac
15307-86-5
ADReCS
Diphenhydramine
58-73-1
ADReCS
Disodium Cromoglycate
15826-37-6
ADReCS
Domperidone
57808-66-9
ADReCS
Donepezil
120014-06-4
ADReCS
duloxetine
136434-34-9
ADReCS
Dyphylline
479-18-5
ADReCS
Enfuvirtide
159519-65-0
ADReCS
Escitalopram
128196-01-0
ADReCS
Esmolol
100286-90-6
ADReCS
Esterified Estrogens
CASNA504
ADReCS
Estradiol
50-28-2
ADReCS
Estrogens Conjugated Synthetic A
12126-59-9
ADReCS
Estropipate
7280-37-7
ADReCS
Ethosuximide
77-67-8
ADReCS
Etodolac
41340-25-4
ADReCS
Everolimus
159351-69-6
PROTECT
Famotidine
76824-35-6
ADReCS
Febuxostat
144060-53-7
ADReCS
Felodipine
72509-76-3
ADReCS
Fesoterodine
286930-03-8
SIDER
Flecainide
54143-55-4
ADReCS
Fluorouracil
51-21-8
ADReCS
Flurazepam
17617-23-1
ADReCS
Fluticasone
90566-53-3
SIDER
Fluticasone Propionate
80474-14-2
ADReCS
Folic Acid
59-30-3
ADReCS
Gabapentin
60142-96-3
ADReCS
Ganciclovir
82410-32-0
ADReCS
Glycopyrrolate
596-51-0
ADReCS
Guanfacine
29110-47-2
ADReCS
Guanidine
113-00-8
ADReCS
Histrelin Acetate
76712-82-8
ADReCS
human insulin
11061-68-0
ADReCS
Hydrochlorothiazide
58-93-5
MetaADEDB
Hydrocortisone
50-23-7
ADReCS
Hydroxocobalamin
13422-51-0
ADReCS
Hydroxychloroquine
118-42-3
ADReCS
Imiquimod
99011-02-6
PROTECT
Indapamide
26807-65-8
ADReCS
Interferon Alfa-2a Recombinant
76543-88-9
ADReCS
Interferon alfacon-1
118390-30-0
ADReCS
Iopamidol
60166-93-0
ADReCS
Isosorbide
652-67-5
ADReCS
Ketotifen
34580-14-8
ADReCS
Lacosamide
175481-36-4
ADReCS
Lamotrigine
84057-84-1
ADReCS
Lansoprazole
103577-45-3
ADReCS
Lenalidomide
191732-72-6
ADReCS
Letrozole
112809-51-5
ADReCS
Leuprolide
53714-56-0
ADReCS
Leuprolide acetate
74381-53-6
SIDER
Levetiracetam
102767-28-2
ADReCS
Levothyroxine
51-48-9
ADReCS
Lisdexamfetamine
608137-32-2
ADReCS
Lisinopril
83915-83-7
ADReCS
Lorazepam
846-49-1
ADReCS
Medroxyprogesterone
520-85-4
ADReCS
Medroxyprogesterone Acetate
71-58-9
ADReCS
melatonin
73-31-4
PROTECT
Memantine
19982-08-2
ADReCS
Mephenytoin
50-12-4
ADReCS
Metaxalone
1665-48-1
ADReCS
Methadone
76-99-3
ADReCS
Methamphetamine
537-46-2
ADReCS
Methotrexate
59-05-2
ADReCS
Methsuximide
77-41-8
ADReCS
Methylphenidate
113-45-1
ADReCS
Metronidazole
443-48-1
ADReCS
Milnacipran
92623-85-3
ADReCS
Montelukast
158966-92-8
ADReCS
Nabilone
51022-71-0
ADReCS
Naloxone
465-65-6
ADReCS
Naltrexone
16590-41-3
ADReCS
Nandrolone phenpropionate
434-22-0
ADReCS
Nicotine
54-11-5
ADReCS
Nitrazepam
146-22-5
ADReCS
Nizatidine
76963-41-2
ADReCS
Norfloxacin
70458-96-7
ADReCS
Octreotide
83150-76-9
ADReCS
Olsalazine
15722-48-2
ADReCS
Omeprazole
73590-58-6
ADReCS
Oxtriphylline
4499-40-5
ADReCS
Oxymetholone
434-07-1
ADReCS
Paroxetine
61869-08-7
ADReCS
Peginterferon alfa-2a
198153-51-4
ADReCS
Pemoline
2152-34-3
ADReCS
Pentazocine
359-83-1
ADReCS
Perampanel
380917-97-5
PROTECT
Phenobarbital
50-06-6
ADReCS
Pramipexole
104632-26-0
ADReCS
Prednisone
53-03-2
ADReCS
Pregabalin
148553-50-8
PROTECT
Primidone
125-33-7
ADReCS
Progesterone
57-83-0
ADReCS
Quetiapine
111974-69-7
ADReCS
Ribavirin
36791-04-5
ADReCS
Rizatriptan
145202-66-0
ADReCS
Romiplostim
267639-76-9
PROTECT
Ropinirole
91374-21-9
ADReCS
Rotigotine
99755-59-6
PROTECT
Salbutamol
18559-94-9
ADReCS
Saquinavir
127779-20-8
ADReCS
Selegiline
14611-51-9
ADReCS
Sodium bicarbonate
144-55-8
ADReCS
Sodium Phenylbutyrate
1716-12-7
PROTECT
Somatropin recombinant
12629-01-5
PROTECT
stiripentol
49763-96-4
PROTECT
Sulfacetamide
144-80-9
ADReCS
Tamoxifen
10540-29-1
ADReCS
Tapentadol
175591-23-8
SIDER
Testosterone
58-22-0
ADReCS
Tetrabenazine
58-46-8
ADReCS
Tetrahydrobiopterin
17528-72-2
ADReCS
Thalidomide
50-35-1
ADReCS
Theophylline
58-55-9
ADReCS
Thiabendazole
148-79-8
ADReCS
Tiagabine
115103-54-3
ADReCS
Tolcapone
134308-13-7
ADReCS
Tramadol
27203-92-5
ADReCS
Triamcinolone
124-94-7
ADReCS
Triazolam
28911-01-5
ADReCS
Trimethadione
127-48-0
ADReCS
Urea
57-13-6
ADReCS
Valrubicin
56124-62-0
ADReCS
Varenicline
249296-44-4
ADReCS
Vigabatrin
60643-86-9
ADReCS
Zaleplon
151319-34-5
PROTECT
Ziconotide
107452-89-1
ADReCS
Zidovudine
30516-87-1
ADReCS
Zolmitriptan
139264-17-8
ADReCS
Zonisamide
68291-97-4
ADReCS
Zopiclone
43200-80-2
ADReCS
List of proteins causing Irritability
Protein Name
Uniprot ID
Source
Alpha-1A adrenergic receptor
P35348
22722194
Amine oxidase [flavin-containing] A
P21397
22722194
Gamma-aminobutyric acid receptor subunit alpha-1 precursor
P14867
22722194
Gamma-aminobutyric acid receptor subunit alpha-2 precursor
P47869
22722194
Gamma-aminobutyric acid receptor subunit alpha-3 precursor
P34903
22722194
Gamma-aminobutyric acid receptor subunit alpha-4 precursor
P48169
22722194
Gamma-aminobutyric acid receptor subunit alpha-5 precursor
P31644
22722194
Gamma-aminobutyric acid receptor subunit alpha-6 precursor
P30191
22722194
Glutamate receptor 2 precursor
P19491
22722194
Neuronal acetylcholine receptor subunit alpha-4 precursor
P43681
22722194
Neuronal acetylcholine receptor subunit alpha-7 precursor
P36544
22722194
Serine/threonine-protein kinase GRIK2
Q5HZ38
22722194
InAADR: Drug-Protein-ADRs database