Drugs Causing Intestinal Perforation: 159
Drug Name	CAS Number	Source
Acetylcysteine	616-91-1	MetaADEDB
Adalimumab	331731-18-1	PROTECT
Aldesleukin	85898-30-2	ADReCS
Alizapride	59338-93-1	MetaADEDB
Ambrisentan	177036-94-1	MetaADEDB
Aminophylline	317-34-0	MetaADEDB
Ampicillin	69-53-4	MetaADEDB
Aprepitant	170729-80-3	MetaADEDB
Aripiprazole	129722-12-9	ADReCS
Atazanavir	198904-31-3	MetaADEDB
Barium Sulfate	7727-43-7	ADReCS
Benazepril	86541-75-5	MetaADEDB
Bendroflumethiazide	73-48-3	MetaADEDB
Benzatropine	86-13-5	MetaADEDB
Benzoyl Peroxide	94-36-0	MetaADEDB
Beractant	108778-82-1	ADReCS
beta-Methyldigoxin	30685-43-9	MetaADEDB
Betamethasone	378-44-9	ADReCS
Bevacizumab	216974-75-3	PROTECT
Bisoprolol	66722-44-9	MetaADEDB
Bleomycin sulfate	9041-93-4	MetaADEDB
Bortezomib	179324-69-7	ADReCS
Bupropion	34841-39-9	ADReCS
Calcium	7440-70-2	MetaADEDB
Candesartan cilexetil	145040-37-5	MetaADEDB
Capecitabine	154361-50-9	MetaADEDB
Carisoprodol	78-44-4	MetaADEDB
Cefadroxil	66592-87-8	MetaADEDB
Cefmetazole	56796-20-4	MetaADEDB
Cefotaxime	63527-52-6	MetaADEDB
Cefprozil	92665-29-7	MetaADEDB
Celecoxib	169590-42-5	ADReCS
Chlorthalidone	77-36-1	MetaADEDB
Ciprofloxacin	85721-33-1	ADReCS
Cisplatin	15663-27-1	MetaADEDB
Clarithromycin	81103-11-9	MetaADEDB
Clindamycin	18323-44-9	MetaADEDB
Clodronate	10596-23-3	MetaADEDB
Clopidogrel	113665-84-2	PROTECT
Clozapine	5786-21-0	MetaADEDB
Codeine	76-57-3	MetaADEDB
Cyclobenzaprine	303-53-7	MetaADEDB
Cyclosporine	59865-13-3	MetaADEDB
Daunorubicin	20830-81-3	MetaADEDB
Dexamethasone	50-02-2	ADReCS
Diclofenac	15307-86-5	ADReCS
Docetaxel	114977-28-5	ADReCS
Domperidone	57808-66-9	MetaADEDB
Entacapone	130929-57-6	MetaADEDB
Erlotinib	183321-74-6	MetaADEDB
Esmolol	100286-90-6	ADReCS
Fentanyl	437-38-7	PROTECT
Ferric sulfate	10028-22-5	MetaADEDB
Flumazenil	78755-81-4	MetaADEDB
Fluorometholone	426-13-1	MetaADEDB
Fluoxetine	54910-89-3	MetaADEDB
Flurbiprofen	5104-49-4	MetaADEDB
Ganciclovir	82410-32-0	MetaADEDB
Gemfibrozil	25812-30-0	MetaADEDB
Glatiramer Acetate	147245-92-9	MetaADEDB
glycerol	56-81-5	MetaADEDB
hydrocodone	125-29-1	MetaADEDB
Hydrocortisone	50-23-7	ADReCS
Hydromorphone	466-99-9	ADReCS
Ibritumomab	174722-31-7	ADReCS
Ibuprofen	15687-27-1	PROTECT
imidapril	89371-37-9	MetaADEDB
Imipramine	50-49-7	MetaADEDB
Indapamide	26807-65-8	MetaADEDB
Indomethacin	53-86-1	MetaADEDB
Infliximab	170277-31-3	PROTECT
Ipilimumab	477202-00-9	PROTECT
Ixabepilone	219989-84-1	MetaADEDB
Ketorolac	66635-83-4	MetaADEDB
ketorolac tromethamine	74103-07-4	MetaADEDB
L-Carnitine	541-15-1	MetaADEDB
Latanoprost	130209-82-4	MetaADEDB
Lenalidomide	191732-72-6	ADReCS
Leucovorin	1492-18-8	MetaADEDB
Levomepromazine	60-99-1	MetaADEDB
Linezolid	165800-03-3	MetaADEDB
Lisinopril	83915-83-7	MetaADEDB
Lofepramine	23047-25-8	MetaADEDB
Lomefloxacin	98079-51-7	ADReCS
Lomotil	55840-97-6	MetaADEDB
Loperamide	53179-11-6	MetaADEDB
Loratadine	79794-75-5	MetaADEDB
Losartan	114798-26-4	MetaADEDB
magnesium citrate	7779-25-1	MetaADEDB
Mannitol	69-65-8	MetaADEDB
Maraviroc	376348-65-1	MetaADEDB
Medrysone	2668-66-8	ADReCS
Meloxicam	71125-38-7	ADReCS
Meropenem	119478-56-7	MetaADEDB
methenolone acetate	434-05-9	MetaADEDB
Methotrexate	59-05-2	MetaADEDB
Methylprednisolone	83-43-2	ADReCS
Metoprolol	37350-58-6	MetaADEDB
Metronidazole	443-48-1	MetaADEDB
Miconazole	22916-47-8	MetaADEDB
mizoribine	50924-49-7	MetaADEDB
Morphine	57-27-2	MetaADEDB
Mycophenolic acid	24280-93-1	ADReCS
Nitric Oxide	10102-43-9	MetaADEDB
Nitrofurantoin	67-20-9	MetaADEDB
Norepinephrine	51-41-2	MetaADEDB
Ofloxacin	82419-36-1	ADReCS
olmesartan medoxomil	144689-63-4	MetaADEDB
Ondansetron	99614-02-5	MetaADEDB
Oxaliplatin	61825-94-3	MetaADEDB
Oxycodone	76-42-6	ADReCS
Paclitaxel	33069-62-4	ADReCS
Parecoxib	202409-33-4	MetaADEDB
Paroxetine	61869-08-7	MetaADEDB
Pazopanib	444731-52-6	PROTECT
Pemetrexed	137281-23-3	PROTECT
Phosphorus	7723-14-0	MetaADEDB
Pinaverium Bromide	53251-94-8	MetaADEDB
Polaprezinc	107667-60-7	MetaADEDB
Povidone Iodine	25655-41-8	MetaADEDB
Prazepam	2955-38-6	MetaADEDB
Prednisone	53-03-2	ADReCS
Pregabalin	148553-50-8	ADReCS
Prochlorperazine	58-38-8	MetaADEDB
Propoxyphene	469-62-5	MetaADEDB
Pyrazinamide	98-96-4	MetaADEDB
Pyridoxine	65-23-6	MetaADEDB
Quinapril	85441-61-8	MetaADEDB
Quinidine	56-54-2	MetaADEDB
Rasagiline	136236-51-6	ADReCS
Rifabutin	72559-06-9	MetaADEDB
Rizatriptan	145202-66-0	MetaADEDB
Salmeterol	89365-50-4	MetaADEDB
sarpogrelate	125926-17-2	MetaADEDB
Sevelamer	152751-57-0	ADReCS
simethicone	8050-81-5	MetaADEDB
Sodium bicarbonate	144-55-8	MetaADEDB
Sodium Polystyrene Sulfonate	25704-18-1	ADReCS
Sucralfate	54182-58-0	MetaADEDB
sunitinib	557795-19-4	PROTECT
Telithromycin	191114-48-4	MetaADEDB
Temocapril	111902-57-9	MetaADEDB
Temsirolimus	162635-04-3	ADReCS
Terbutaline	23031-25-6	MetaADEDB
Thalidomide	50-35-1	ADReCS
Thioridazine	50-52-2	MetaADEDB
Tibolone	5630-53-5	MetaADEDB
Ticarcillin	34787-01-4	MetaADEDB
Tipranavir	174484-41-4	MetaADEDB
Tobramycin	32986-56-4	MetaADEDB
Tretinoin	302-79-4	MetaADEDB
Triamcinolone	124-94-7	ADReCS
Triamterene	396-01-0	MetaADEDB
Trimethoprim	738-70-5	MetaADEDB
Vancomycin	1404-90-6	MetaADEDB
Vandetanib	443913-73-3	PROTECT
Voriconazole	137234-62-9	ADReCS
Zafirlukast	107753-78-6	MetaADEDB
Zopiclone	43200-80-2	MetaADEDB

List of proteins causing Intestinal Perforation
Protein Name	Uniprot ID	Source