Drugs Causing Injection Site Irritation: 74
Drug Name	CAS Number	Source
Aflibercept	862111-32-8	PROTECT
Alprostadil	745-65-3	MetaADEDB
Amifostine	20537-88-6	MetaADEDB
Amprenavir	161814-49-9	MetaADEDB
Arginine	74-79-3	ADReCS
Benzylpenicillin	61-33-6	MetaADEDB
bismuth subsalicylate	14882-18-9	MetaADEDB
Bucindolol	71119-11-4	MetaADEDB
Butalbital	77-26-9	MetaADEDB
Carisoprodol	78-44-4	MetaADEDB
Cefotaxime	63527-52-6	MetaADEDB
CNTO 1275	815610-63-0	ADReCS
Colestipol hydrochloride	37296-80-3	MetaADEDB
Cyclobenzaprine	303-53-7	MetaADEDB
Darbepoetin alfa	209810-58-2	ADReCS
Dicyclomine	77-19-0	MetaADEDB
duloxetine	136434-34-9	MetaADEDB
Ecallantide	460738-38-9	ADReCS
Enoxaparin	9005-49-6	ADReCS
epoetin alfa	11096-26-7	ADReCS
Ethacrynic acid	58-54-8	ADReCS
Etodolac	41340-25-4	MetaADEDB
Fexofenadine	83799-24-0	MetaADEDB
Fluocinonide	356-12-7	MetaADEDB
Fluorometholone	426-13-1	MetaADEDB
Flutamide	13311-84-7	ADReCS
Follitropin Alfa	56832-30-5	PROTECT
Fulvestrant	129453-61-8	MetaADEDB
Gadoversetamide	131069-91-5	PROTECT
Glatiramer Acetate	147245-92-9	MetaADEDB
Glutamine	56-85-9	MetaADEDB
golimumab	476181-74-5	PROTECT
hydrocodone	125-29-1	MetaADEDB
Hydroxychloroquine	118-42-3	MetaADEDB
Icatibant	130308-48-4	PROTECT
Lanreotide	108736-35-2	MetaADEDB
Leflunomide	75706-12-6	MetaADEDB
Lisinopril	83915-83-7	MetaADEDB
Lomotil	55840-97-6	MetaADEDB
Meloxicam	71125-38-7	MetaADEDB
Menotropins	61489-71-2	ADReCS
Mercaptopurine	50-44-2	MetaADEDB
Methotrexate	59-05-2	MetaADEDB
methylprednisolone acetate	53-36-1	MetaADEDB
Mometasone	105102-22-5	MetaADEDB
montelukast sodium	151767-02-1	MetaADEDB
Nabumetone	42924-53-8	MetaADEDB
Naftifine	65472-88-0	ADReCS
Nalbuphine	20594-83-6	MetaADEDB
Nortriptyline	72-69-5	MetaADEDB
Olanzapine	132539-06-1	PROTECT
Orphenadrine	83-98-7	MetaADEDB
Pantoprazole	102625-70-7	MetaADEDB
Pethidine	57-42-1	MetaADEDB
Phenprocoumon	435-97-2	MetaADEDB
Polidocanol	9002-92-0	ADReCS
Progesterone	57-83-0	MetaADEDB
Pyridoxine	65-23-6	MetaADEDB
Quinapril	85441-61-8	MetaADEDB
Ranibizumab	347396-82-1	PROTECT
Rasburicase	134774-45-1	ADReCS
Ribavirin	36791-04-5	MetaADEDB
scopolamine	51-34-3	ADReCS
Somatropin recombinant	12629-01-5	PROTECT
Sulfacetamide	144-80-9	ADReCS
Sulfasalazine	599-79-1	MetaADEDB
Sumatriptan	103628-46-2	MetaADEDB
Tesamorelin	901758-09-6	ADReCS
Tizanidine	51322-75-9	MetaADEDB
Tobramycin	32986-56-4	MetaADEDB
Valsartan	137862-53-4	MetaADEDB
Verteporfin	129497-78-5	MetaADEDB
Vinorelbine	71486-22-1	MetaADEDB
Zoledronate	118072-93-8	PROTECT

List of proteins causing Injection Site Irritation
Protein Name	Uniprot ID	Source
delta-Type opioid receptor	P41143	22722194
Kappa-Type opioid receptor	P41145	22722194
Mu-Type opioid receptor	P35372	22722194
Sigma non-opioid intracellular receptor 1	Q99720	22722194