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Drugs Causing Dry Eye: 283
Drug Name
CAS Number
Source
Abatacept
332348-12-6
PROTECT
Acebutolol
37517-30-9
ADReCS
Acetazolamide
59-66-5
MetaADEDB
Acetylsalicylic acid
50-78-2
MetaADEDB
Aciclovir
59277-89-3
MetaADEDB
Acitretin
55079-83-9
ADReCS
Alendronate Sodium
121268-17-5
MetaADEDB
Almotriptan
154323-57-6
SIDER
Almotriptan Malate
181183-52-8
ADReCS
Alprazolam
28981-97-7
MetaADEDB
Amiodarone
1951-25-3
ADReCS
Amoxicillin
26787-78-0
MetaADEDB
Amphetamine
300-62-9
MetaADEDB
Amphotericin B
1397-89-3
ADReCS
Anastrozole
120511-73-1
MetaADEDB
Apraclonidine
66711-21-5
ADReCS
Aripiprazole
129722-12-9
ADReCS
Arsenic trioxide
1327-53-3
ADReCS
Atenolol
29122-68-7
ADReCS
Atorvastatin
134523-00-5
ADReCS
Atropine
51-55-8
ADReCS
Azelastine
58581-89-8
MetaADEDB
Azithromycin
83905-01-5
ADReCS
Bacitracin
1405-87-4
MetaADEDB
bazedoxifene
198481-32-2
PROTECT
betamethasone dipropionate
5593-20-4
MetaADEDB
Betaxolol
63659-18-7
ADReCS
Bexarotene
153559-49-0
ADReCS
Bimatoprost
155206-00-1
ADReCS
Biotin
58-85-5
MetaADEDB
Bisacodyl
603-50-9
MetaADEDB
Bisoprolol
66722-44-9
MetaADEDB
Boceprevir
394730-60-0
PROTECT
Bortezomib
179324-69-7
PROTECT
Botulinum Toxin Type A
93384-43-1
ADReCS
Brimonidine
59803-98-4
ADReCS
Brinzolamide
138890-62-7
ADReCS
Bupivacaine
2180-92-9
MetaADEDB
Buprenorphine
52485-79-7
ADReCS
Bupropion
34841-39-9
ADReCS
Buserelin
57982-77-1
ADReCS
Buserelin acetate
68630-75-1
MetaADEDB
Butalbital
77-26-9
MetaADEDB
Caffeine
58-08-2
MetaADEDB
Calcitriol
32222-06-3
MetaADEDB
Calcium
7440-70-2
MetaADEDB
Candesartan
139481-59-7
MetaADEDB
Capecitabine
154361-50-9
PROTECT
Captopril
62571-86-2
ADReCS
Carbamazepine
298-46-4
MetaADEDB
Carvedilol
72956-09-3
MetaADEDB
Cefadroxil
66592-87-8
MetaADEDB
Cefditoren
104145-95-1
MetaADEDB
cefditoren pivoxil
117467-28-4
MetaADEDB
Cefepime
88040-23-7
MetaADEDB
Cefuroxime axetil
64544-07-6
MetaADEDB
Chlordiazepoxide
58-25-3
MetaADEDB
Chlorhexidine
55-56-1
MetaADEDB
Chlorhexidine gluconate
18472-51-0
MetaADEDB
Chloroquine
54-05-7
MetaADEDB
Chlorthalidone
77-36-1
MetaADEDB
Chlorzoxazone
95-25-0
MetaADEDB
Chorionic Gonadotropin
9002-61-3
ADReCS
Cidofovir
113852-37-2
ADReCS
Cilest
79871-54-8
MetaADEDB
Cimetidine
51481-61-9
MetaADEDB
Ciprofloxacin
85721-33-1
ADReCS
Citalopram
59729-33-8
ADReCS
Clindamycin
18323-44-9
MetaADEDB
Clonidine
4205-90-7
ADReCS
Clotrimazole
23593-75-1
MetaADEDB
Codeine
76-57-3
MetaADEDB
coenzyme Q10
303-98-0
MetaADEDB
Colestipol hydrochloride
37296-80-3
MetaADEDB
Conjugated Estrogens
438-67-5
ADReCS
Cortisporin
8024-64-4
MetaADEDB
Cromoglicic acid
16110-51-3
ADReCS
Dapsone
80-08-0
MetaADEDB
Darifenacin
133099-04-4
ADReCS
Darunavir
206361-99-1
PROTECT
Dasatinib
302962-49-8
ADReCS
Delavirdine
136817-59-9
ADReCS
Desoximetasone
382-67-2
MetaADEDB
diazinon
333-41-5
MetaADEDB
Didanosine
69655-05-6
ADReCS
Difluprednate
23674-86-4
ADReCS
Diphenhydramine
58-73-1
MetaADEDB
Divalproex Sodium
76584-70-8
ADReCS
Docetaxel
114977-28-5
MetaADEDB
Dolasetron
115956-12-2
MetaADEDB
Donepezil
120014-06-4
ADReCS
Dorzolamide
120279-96-1
ADReCS
Doxorubicin
23214-92-8
ADReCS
Doxycycline
564-25-0
MetaADEDB
duloxetine
136434-34-9
SIDER
Dutasteride
164656-23-9
MetaADEDB
Econazole
27220-47-9
MetaADEDB
Eflornithine Hydrochloride
62878-23-9
ADReCS
Eletriptan
143322-58-1
ADReCS
Eltrombopag
496775-61-2
PROTECT
Emedastine
87233-61-2
ADReCS
Enalapril
75847-73-3
ADReCS
enalapril maleate
76095-16-4
SIDER
Enalaprilat
76420-72-9
ADReCS
epalrestat
82159-09-9
MetaADEDB
Erlotinib
183321-74-6
PROTECT
Erythromycin
114-07-8
MetaADEDB
Estradiol
50-28-2
MetaADEDB
Eszopiclone
138729-47-2
ADReCS
Exemestane
107868-30-4
MetaADEDB
Ezetimibe
163222-33-1
MetaADEDB
Famciclovir
104227-87-4
MetaADEDB
Fenofibrate
49562-28-9
MetaADEDB
Fentanyl
437-38-7
ADReCS
Ferumoxytol
722492-56-0
ADReCS
Fesoterodine
286930-03-8
SIDER
Fexofenadine
83799-24-0
ADReCS
Finasteride
98319-26-7
MetaADEDB
Fluocinolone Acetonide
67-73-2
ADReCS
Fluorometholone
426-13-1
MetaADEDB
Fluoxetine
54910-89-3
ADReCS
Fluticasone
90566-53-3
SIDER
Fluticasone Propionate
80474-14-2
ADReCS
Fluvoxamine
54739-18-3
ADReCS
Fosinopril
98048-97-6
MetaADEDB
Fulvestrant
129453-61-8
MetaADEDB
Gabapentin
60142-96-3
ADReCS
Ganciclovir
82410-32-0
ADReCS
Gatifloxacin
112811-59-3
ADReCS
Gefitinib
184475-35-2
PROTECT
Glatiramer Acetate
147245-92-9
ADReCS
Goserelin
65807-02-5
ADReCS
Hydrochlorothiazide
58-93-5
MetaADEDB
Hydrocortisone
50-23-7
PROTECT
Hydromorphone
466-99-9
ADReCS
Hydroxychloroquine
118-42-3
MetaADEDB
Ibuprofen
15687-27-1
ADReCS
Idursulfase
50936-59-9
ADReCS
Ifosfamide
3778-73-2
ADReCS
Imatinib
152459-95-5
ADReCS
Imipramine
50-49-7
MetaADEDB
Imiquimod
99011-02-6
MetaADEDB
Interferon Alfa-2a Recombinant
76543-88-9
ADReCS
Ioversol
87771-40-2
MetaADEDB
Ipratropium bromide
22254-24-6
MetaADEDB
Isosulfan Blue
68238-36-8
ADReCS
Isotretinoin
4759-48-2
ADReCS
Ketoconazole
65277-42-1
MetaADEDB
Ketorolac
66635-83-4
ADReCS
Ketotifen
34580-14-8
ADReCS
Labetalol
36894-69-6
ADReCS
Lamotrigine
84057-84-1
ADReCS
Lansoprazole
103577-45-3
ADReCS
Lasofoxifene
180916-16-9
PROTECT
Latanoprost
130209-82-4
ADReCS
Lenalidomide
191732-72-6
ADReCS
Letrozole
112809-51-5
MetaADEDB
Leucovorin
1492-18-8
ADReCS
Leuprolide acetate
74381-53-6
MetaADEDB
Levobunolol
47141-42-4
MetaADEDB
Levonorgestrel
797-63-7
MetaADEDB
Linezolid
165800-03-3
MetaADEDB
Lisinopril
83915-83-7
MetaADEDB
Lodoxamide
53882-12-5
ADReCS
Loteprednol
82034-46-6
ADReCS
Lovastatin
75330-75-5
MetaADEDB
Mannitol
69-65-8
MetaADEDB
Mefloquine
53230-10-7
MetaADEDB
melatonin
73-31-4
MetaADEDB
Meloxicam
71125-38-7
MetaADEDB
Melphalan
148-82-3
MetaADEDB
Mesalazine
89-57-6
ADReCS
Metaxalone
1665-48-1
MetaADEDB
Methocarbamol
532-03-6
MetaADEDB
Methotrexate
59-05-2
MetaADEDB
Methylphenidate
113-45-1
ADReCS
Methylprednisolone
83-43-2
MetaADEDB
methylprednisolone acetate
53-36-1
MetaADEDB
Metoprolol
37350-58-6
ADReCS
Miconazole
22916-47-8
MetaADEDB
Moexipril
103775-10-6
MetaADEDB
Moxifloxacin
151096-09-2
ADReCS
Mycophenolate mofetil
128794-94-5
MetaADEDB
Nabilone
51022-71-0
ADReCS
Nabumetone
42924-53-8
MetaADEDB
Nadolol
42200-33-9
ADReCS
Naproxen
22204-53-1
ADReCS
Naratriptan
121679-13-8
ADReCS
Nefazodone
83366-66-9
ADReCS
Neomycin
1404-04-2
MetaADEDB
Nepafenac
78281-72-8
ADReCS
Nilotinib
641571-10-0
ADReCS
Nitrofurantoin
67-20-9
MetaADEDB
ocriplasmin
1048016-09-6
PROTECT
Olanzapine
132539-06-1
ADReCS
Olopatadine
113806-05-6
ADReCS
Olsalazine
15722-48-2
ADReCS
Omeprazole
73590-58-6
ADReCS
Orphenadrine
83-98-7
MetaADEDB
Oxaprozin
21256-18-8
MetaADEDB
Oxybutynin
5633-20-5
ADReCS
Paclitaxel
33069-62-4
PROTECT
Paliperidone
144598-75-4
ADReCS
Pamidronate
40391-99-9
MetaADEDB
Panitumumab
339177-26-3
PROTECT
Pegaptanib
222716-86-1
PROTECT
Pemirolast
100299-08-9
ADReCS
Penicillin v
87-08-1
MetaADEDB
Pentostatin
53910-25-1
ADReCS
Perindopril
107133-36-8
MetaADEDB
Phenobarbital
50-06-6
MetaADEDB
Pilocarpine
92-13-7
ADReCS
Pindolol
13523-86-9
MetaADEDB
Piroxicam
36322-90-4
MetaADEDB
Pixantrone
784209-05-8
PROTECT
Posaconazole
171228-49-2
ADReCS
Pramipexole
104632-26-0
ADReCS
Pregabalin
148553-50-8
ADReCS
Prochlorperazine edisylate
1257-78-9
MetaADEDB
Progesterone
57-83-0
MetaADEDB
Propoxyphene
469-62-5
MetaADEDB
Propranolol
525-66-6
ADReCS
Quetiapine
111974-69-7
ADReCS
Quinidine
56-54-2
MetaADEDB
Rabeprazole
117976-89-3
ADReCS
Ranibizumab
347396-82-1
ADReCS
Ribavirin
36791-04-5
PROTECT
Rimexolone
49697-38-3
ADReCS
Risedronate
105462-24-6
ADReCS
Risperidone
106266-06-2
ADReCS
Rizatriptan
145202-66-0
ADReCS
Saquinavir
127779-20-8
ADReCS
scopolamine
51-34-3
MetaADEDB
Selegiline
14611-51-9
ADReCS
selenium
7782-49-2
MetaADEDB
Sibutramine
106650-56-0
ADReCS
Sildenafil
139755-83-2
ADReCS
Solifenacin
242478-37-1
ADReCS
Sotalol
3930-20-9
MetaADEDB
Sucralfate
54182-58-0
MetaADEDB
Sulindac
38194-50-2
MetaADEDB
Tacrine
321-64-2
ADReCS
Tacrolimus
104987-11-3
ADReCS
Tadalafil
171596-29-5
MetaADEDB
Tafluprost
209860-87-7
ADReCS
Tamoxifen
10540-29-1
MetaADEDB
Temazepam
846-50-4
MetaADEDB
Temozolomide
85622-93-1
ADReCS
Terconazole
67915-31-5
MetaADEDB
Tetracycline
60-54-8
MetaADEDB
Thalidomide
50-35-1
ADReCS
Theophylline
58-55-9
MetaADEDB
Thyrotropin Releasing Hormone
24305-27-9
ADReCS
Timolol
26839-75-8
ADReCS
Tiotropium
186691-13-4
MetaADEDB
Tolazamide
1156-19-0
ADReCS
Tolbutamide
64-77-7
MetaADEDB
Tolterodine
124937-51-5
ADReCS
Toremifene
89778-26-7
ADReCS
Tramadol
27203-92-5
ADReCS
Travoprost
157283-68-6
ADReCS
Trazodone
19794-93-5
ADReCS
Tretinoin
302-79-4
ADReCS
Triamcinolone
124-94-7
MetaADEDB
Triamcinolone acetonide
76-25-5
MetaADEDB
Trimethoprim
738-70-5
ADReCS
Trospium
10405-02-4
ADReCS
Unoprostone
120373-36-6
ADReCS
Valproic Acid
99-66-1
ADReCS
Vandetanib
443913-73-3
PROTECT
Varenicline
249296-44-4
ADReCS
Venlafaxine
93413-69-5
ADReCS
Verteporfin
129497-78-5
ADReCS
Vilazodone
163521-12-8
ADReCS
Vitamin A
68-26-8
MetaADEDB
Voriconazole
137234-62-9
ADReCS
Zalcitabine
7481-89-2
ADReCS
Zaleplon
151319-34-5
ADReCS
zinc
7440-66-6
MetaADEDB
Ziprasidone
146939-27-7
ADReCS
Zoledronate
118072-93-8
MetaADEDB
Zolmitriptan
139264-17-8
ADReCS
Zopiclone
43200-80-2
ADReCS
List of proteins causing Dry Eye
Protein Name
Uniprot ID
Source
5-hydroxytryptamine receptor 1A
P08908
22722194
Beta-1 adrenergic receptor
P18090
22722194
Beta-2 adrenergic receptor
P07550
22722194
Beta-3 adrenergic receptor
P13945
22722194
InAADR: Drug-Protein-ADRs database